A Study on the Incidence of Down's Syndrome and the Interference by Prenatal Screening

doi:10.3877/cma.j.issn.1673-5250.2005.01.110

Objective

To investigate the incidence of Down's syndrome in live birth infants delivered in the hospital, and the effect of prenatal screening in reducing the incidence of Down's syndrome.

Methods

Calculating the incidence of Down's syndrome, and the effect of prenatal screening in reducing the incidence of Down's syndrome was evaluated by a correlation analysis between the prenatal screen rate and the incidence of Down's syndrome.

Results

24. 3% outpatient women at first and second trimester of pregnancy were accepted for the prenatal screening during 2000 to 2002, one case of Down's syndrome fetus was found and prenatally diagnosed. 7 cases of Down's syndrome among 7063 live birth infants were delivered in the same period. Total incidence was 1/883. When the prenatal screen rate increased to 81. 4% during 2003 to 2004, 3 cases of Down's syndrome among 5273 live birth infants were delivered, and the incidence decreased to 1/1758.

Conclusion

The approximate incidence of Down's syndrome in present group might be higher than 1/785. Prenatal screening is an effective method to discover the high-risk cases in first and second trimester. Increasing the screening rate in first and second trimester of pregnancy could reduce the incidence of Down's syndrome in live birth infants.

Key words: Down's syndrome, Incidence, Prenatal screening

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