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中华妇幼临床医学杂志(电子版) ›› 2026, Vol. 22 ›› Issue (01) : 7 -12. doi: 10.3877/cma.j.issn.1673-5250.2026.01.002

专家述评

子宫内膜癌患者免疫治疗的研究现状
吴达莹, 李贵玲()   
  1. 华中科技大学同济医学院附属协和医院肿瘤中心,武汉 430022
  • 收稿日期:2025-10-30 修回日期:2026-01-12 出版日期:2026-02-01
  • 通信作者: 李贵玲

Current research status on immunotherapy for patients with endometrial carcinoma

Daying Wu, Guiling Li()   

  1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
  • Received:2025-10-30 Revised:2026-01-12 Published:2026-02-01
  • Corresponding author: Guiling Li
  • Supported by:
    National Natural Science Foundation of China(81902854)
引用本文:

吴达莹, 李贵玲. 子宫内膜癌患者免疫治疗的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2026, 22(01): 7-12.

Daying Wu, Guiling Li. Current research status on immunotherapy for patients with endometrial carcinoma[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2026, 22(01): 7-12.

子宫内膜癌(EC)是女性生殖系统最常见恶性肿瘤之一,近年发病率呈逐年持续上升趋势。对国际妇产科联盟(FIGO)临床分期为早期的EC患者采取手术治疗的预后良好,但是晚期或复发性EC患者的5年总体生存(OS)率仅约为17%,对其采取传统化疗的疗效常不佳,而且迄今治疗方案选择亦有限,由此可见晚期及复发性EC患者面临严峻的治疗挑战。免疫治疗作为肿瘤治疗领域的重大突破性进展,特别是免疫检查点抑制剂(ICI)在多种实体瘤患者中的成功应用,为晚期及复发性EC患者带来新的希望。笔者拟对EC患者的免疫治疗研究现状进行系统阐述,包括免疫治疗在EC患者一、二线治疗中的研究现状,免疫治疗对EC患者的治疗疗效与新型免疫治疗手段,安全性管理、精准分层治疗及未来发展方向等,旨在为EC患者的临床治疗提供参考依据。

Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and its incidence has been continuously rising in recent years. Patients with early-stage EC defined by the International Federation of Gynecology and Obstetrics (FIGO) clinical staging achieve a good prognosis after surgical treatment, whereas patients with advanced or recurrent EC have a 5-year overall survival (OS) rate of only approximately 17%. Traditional chemotherapy often yields unsatisfactory efficacy, and available therapeutic options remain limited to date, leaving patients with advanced and recurrent EC facing severe therapeutic challenges. Immunotherapy represents a major breakthrough in the field of oncology. In particular, the successful application of immune checkpoint inhibitor (ICI) in a variety of solid tumors has brought new hope for patients with advanced and recurrent EC. This article systematically elaborates the current research status of immunotherapy for EC, covering the application of immunotherapy in first- and second-line treatment, therapeutic efficacy, novel immunotherapeutic strategies, safety management, precise stratified treatment, and future research directions, so as to provide evidence-based reference for the clinical management of EC patients.

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