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中华妇幼临床医学杂志(电子版) ›› 2026, Vol. 22 ›› Issue (01) : 1 -6. doi: 10.3877/cma.j.issn.1673-5250.2026.01.001

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妊娠滋养细胞肿瘤患者免疫治疗研究现状
孟顺瑶1, 曾靖2, 尹如铁2,()   
  1. 1四川大学华西第二医院眉山市妇女儿童医院妇产科,眉山 620000
    2四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2025-10-28 修回日期:2025-11-30 出版日期:2026-02-01
  • 通信作者: 尹如铁

Current research status of immunotherapy for gestational trophoblastic neoplasia

Shunyao Meng1, Jing Zeng2, Rutie Yin2,()   

  1. 1Department of Obstetrics and Gynecology, Meishan Women and Children′s Hospital, Alliance Hospital of West China Second University Hospital, Sichuan University, Meishan 620000, Sichuan Province, China
    2Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Disseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2025-10-28 Revised:2025-11-30 Published:2026-02-01
  • Corresponding author: Rutie Yin
  • Supported by:
    Key Research Project of Science and Technology Department of Sichuan Province: Key Factors Affecting the Diagnosis and Treatment of Major Diseases in Obstetrics and Gynecology(2019YFS0532); Horizontal Science and Technology Project of Sichuan University: Real-World Study on Targeted Immunotherapy for Gynecological Malignant Tumors(23H1223)
引用本文:

孟顺瑶, 曾靖, 尹如铁. 妊娠滋养细胞肿瘤患者免疫治疗研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2026, 22(01): 1-6.

Shunyao Meng, Jing Zeng, Rutie Yin. Current research status of immunotherapy for gestational trophoblastic neoplasia[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2026, 22(01): 1-6.

免疫治疗在妊娠滋养细胞肿瘤(GTN)的全程管理中经历从无到有,逐步得到重视和认可。近年来,随着对GTN发病机制的不断探索,GTN免疫治疗领域取得一定进展。免疫治疗与化疗药物、新型分子靶向药物等联合应用,为耐药难治性GTN患者提供了新的治疗策略和治愈希望。笔者拟就GTN患者免疫治疗的最新进展进行总结,以期为临床医师提供更多的参考和帮助。

Immunotherapy has emerged and gradually gained attention and recognition in the comprehensive management of gestational trophoblastic neoplasia (GTN). In recent years, with continuous exploration of the pathogenesis of GTN, certain progress has been made in the field of GTN immunotherapy. The combined application of immunotherapy with chemotherapeutic drugs and novel targeted drugs has provided new treatment strategies and hopes for cure of patients with drug-resistant and refractory GTN. This article reviews the latest progress in immunotherapy for patients with GTN, aiming to provide more references and assistance for clinicians.

图1 FIGO推荐的对GTN患者的标准诊疗流程图注:FIGO为国际妇产科联盟。GTN为妊娠滋养细胞肿瘤。hCG为绒膜促性腺激素。EMA为依托泊苷+甲氨蝶呤+放线菌素D,CO为环磷酰胺+长春新碱,EP为依托泊苷+顺铂,TP为紫杉醇+顺铂,TE为紫杉醇+依托泊苷,VIP为依托泊苷+异环磷酰胺+顺铂,ICE为异环磷酰胺+卡铂+依托泊苷,BEP为博来霉素+依托泊苷+顺铂,FAEV为氟尿嘧啶+放线菌素D+依托泊苷+长春新碱
图2 GTN中PD-1/PD-L1阻断的发病机制图注:GTN为妊娠滋养细胞肿瘤。PD-1/PD-L1是程序性死亡受体1/程序性死亡受体配体1。B7配体家族、CD28受体家族均属于免疫球蛋白超家族
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