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中华妇幼临床医学杂志(电子版) ›› 2020, Vol. 16 ›› Issue (04) : 386 -391. doi: 10.3877/cma.j.issn.1673-5250.2020.04.003

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间充质干细胞对新生儿缺氧缺血性脑损伤的神经保护作用
袁静1, 杨超2, 陈娟1,†()   
  1. 1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室，成都　610041
    2. 四川省干细胞库干细胞与再生医学研究中心，成都　610036
  • 收稿日期:2020-03-30 修回日期:2020-07-02 出版日期:2020-08-01
  • 通信作者: 陈娟

Neuroprotective effect of mesenchymal stem cells on neonatal hypoxic-ischemic brain damage

Jing Yuan1, Chao Yang2, Juan Chen1,†()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Stem Cells and Regenerative Medicine Research Center, Sichuan Stem Cell Bank, Chengdu 610036, Sichuan Province, China
  • Received:2020-03-30 Revised:2020-07-02 Published:2020-08-01
  • Corresponding author: Juan Chen
  • About author:
    Corresponding author: Chen Juan, Email:
  • Supported by:
    Key Project of Health and Family Planning Commission of Sichuan Province(16ZD019)
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袁静, 杨超, 陈娟. 间充质干细胞对新生儿缺氧缺血性脑损伤的神经保护作用[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(04): 386-391.

Jing Yuan, Chao Yang, Juan Chen. Neuroprotective effect of mesenchymal stem cells on neonatal hypoxic-ischemic brain damage[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(04): 386-391.

新生儿缺氧缺血性脑病(HIE)是围生期窒息导致的缺氧缺血性脑损伤(HIBD)，是导致新生儿急性死亡和远期神经系统疾病的主要原因。对于HIE迄今尚无根治性治疗措施，临床以对症支持治疗为主，疗效有限，而且不能促进受损神经修复和再生。间充质干细胞移植(MSCT)作为治疗新生儿HIE的新策略，在HIBD动物病理模型研究中，具有明显神经保护作用，其作用机制较为复杂，可能通过分泌细胞外囊泡(ECV)、调节免疫、促进神经元修复与再生、抗细胞凋亡及抗氧化等机制发挥作用，从而达到改善预后的目的。笔者拟就间充质干细胞(MSC)对HIBD动物病理模型的神经保护作用可能机制的最新研究进展进行阐述。

关键词: 缺氧缺血，脑, 间质干细胞, 间质干细胞移植, 神经保护, 作用机制, 疾病模型，动物, 动物，新生

Neonatal hypoxic-ischemic encephalopathy (HIE) is a kind of hypoxic-ischemic brain damage (HIBD) caused by perinatal asphyxia, and it is the main cause of acute neonatal death and long-term neurological diseases. The current strategies for treatment of HIE are symptomatic support therapy, while there is no curative treatment for HIE so far. However, the clinical efficacy of this approach is limited and cannot promote repair or regeneration of damaged nerves. Mesenchymal stem cell transplantation (MSCT), as a new strategy for the treatment of neonatal HIE, has exhibited neuroprotective effects in HIBD model animal. Its mechanism is complex, such as secreting extracellular vesicles, regulating immunity, promoting the repair and regeneration of neurons, anti-apoptosis and anti-oxidation. This article summarizes the latest research progresses on possible mechanisms of mesenchymal stem cell (MSC) in neuroprotective effect on HIBD animal disease model.

Key words: Hypoxia-ischemia, brain, Mesenchymal stem cells, Mesenchymal stem cell transplantation, Neuroprotection, Mechanisms of action, Disease models, animal, Animals, newborn
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