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中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (05) : 486 -491. doi: 10.3877/cma.j.issn.1673-5250.2019.05.002

所属专题: 文献

专家约稿

新生儿狼疮综合征病因及发病机制研究现状
刘蕾1, 张怡1, 周开宇1,()   
  1. 1. 四川大学华西第二医院小儿心血管科、出生缺陷与相关妇儿疾病教育部重点实验室、发育与妇儿疾病四川省重点实验室,成都 610041
  • 收稿日期:2018-04-25 修回日期:2018-10-16 出版日期:2019-10-01
  • 通信作者: 周开宇

Etiology and pathogenic mechanism of neonatal lupus syndromes: a comprehensive review

Lei Liu1, Yi Zhang1, Kaiyu Zhou1,()   

  1. 1. Department of Pediatric Cardiovascular, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Key Laboratory of Development and Related Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-04-25 Revised:2018-10-16 Published:2019-10-01
  • Corresponding author: Kaiyu Zhou
  • About author:
    Corresponding author: Zhou Kaiyu, Email:
  • Supported by:
    National Natural Science Foundation of China(81570369, 81571515); Program for Changjiang Scholars and Innovative Research Team in University(IRT0935); Science and Technology Program for the Wellbeing of Chengdu Science and Technology Bureau(2015-HM01-00456-SF)
引用本文:

刘蕾, 张怡, 周开宇. 新生儿狼疮综合征病因及发病机制研究现状[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(05): 486-491.

Lei Liu, Yi Zhang, Kaiyu Zhou. Etiology and pathogenic mechanism of neonatal lupus syndromes: a comprehensive review[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(05): 486-491.

新生儿狼疮综合征(NLS)是一种由母体抗体介导的新生儿获得性自身免疫性疾病。母体抗干燥综合征A(SSA)/Ro与抗干燥综合征B(SSB)/La抗体,可介导新生儿发生暂时性皮肤狼疮和(或)暂时性/永久性先天性心脏传导阻滞(CHB)。NLS虽然罕见,但是对于CHB患儿/胎儿危害严重。目前关于NLS的病因及其发病机制研究较多,但是对于导致NLS发生、发展的具体因素迄今尚不清楚。笔者拟就目前NLS致病因素及其发病机制的最新研究进展进行阐述,旨在为临床治疗NLS及其后续研究提供参考。

Neonatal lupus syndromes (NLS) is an acquired autoimmune disease, which is mediated by maternal antibodies. Maternal anti-Sjogren′s syndrome A (SSA)/Ro, and anti-Sjogren′s syndrome B (SSB)/La antibodies are related with the transient cutaneous lupus and (or) transient/permanent congenital heart block (CHB). Though NLS is rare, it is seriously harmful to children or fetuses with CHB. There are many studies on the etiology and pathogenic mechanism of NLS, but the specific factors leading to the occurrence and development of NLS are still unclear. This article focuses on the current researches on etiology and pathogenesis of NLS and provides references for clinical treatment and further research of NLS.

图1 胎儿自身抗SSA/Ro与抗SSB/La抗体介导的胎儿AVB发生机制的3个时期示意图
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