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中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (04) : 368 -372. doi: 10.3877/cma.j.issn.1673-5250.2019.04.003

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子宫内膜异位症的分子病因学研究现状
张艳1, 孙红丽1, 张娴1, 陈超1,()   
  1. 1. 聊城市人民医院妇产科,山东 252000
  • 收稿日期:2019-03-29 修回日期:2019-07-02 出版日期:2019-08-01
  • 通信作者: 陈超

Current research status on molecular etiology of endometriosis

Yan Zhang1, Hongli Sun1, Xian Zhang1, Chao Chen1,()   

  1. 1. Department of Obstetrics and Gynecology, Liaocheng People′s Hospital, Liaocheng 252000, Shandong Province, China
  • Received:2019-03-29 Revised:2019-07-02 Published:2019-08-01
  • Corresponding author: Chao Chen
  • About author:
    Corresponding author: Chen Chao, Email:
  • Supported by:
    Natural Science Foundation of Shandong Province(ZR2015HL045, ZR2016CB12)
引用本文:

张艳, 孙红丽, 张娴, 陈超. 子宫内膜异位症的分子病因学研究现状[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(04): 368-372.

Yan Zhang, Hongli Sun, Xian Zhang, Chao Chen. Current research status on molecular etiology of endometriosis[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(04): 368-372.

子宫内膜异位症(EMS)是子宫内膜腺体和基质种植于子宫以外的一种雌激素依赖性疾病,是引起该病患者盆腔疼痛和不孕的常见因素。EMS的发病机制迄今尚未完全阐明,是妇产科临床和基础研究的热点。目前研究认为,EMS发病的分子机制不纯粹是某一生物学特征异常,尚涉及腹膜侵袭、血管形成、细胞凋亡、细胞黏附及自噬等方面,并且某一信号通路异常,参与EMS发病过程的各个环节,而涉及整个通路调控网络异常。笔者拟从腹膜的侵袭、血管形成、细胞凋亡、细胞黏附、自噬等方面,对EMS的分子病因学最新研究进展进行阐述。

Endometriosis (EMS) is an estrogen-dependent disease in which the glands and stroma of the endometrium grow outside the uterus and is a common cause of pelvic pain and infertility. Pathogenesis of EMS has not yet been fully understood, and it is a hot topic in clinical and basic research of obstetrics and gynecology. Current studies results have shown that the molecular mechanism of EMS is not simply an abnormality of some biological characteristics. It involves the invasion of endometrium into peritoneum, angiogenesis, apoptosis, cell adhesion, autophagy and other aspects. This article focuses on latest research progresses of molecular etiology of EMS from the aspects of invasion of endometrium into peritoneum, angiogenesis, apoptosis, cell adhesion, autophagy and so on.

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