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中华妇幼临床医学杂志(电子版) ›› 2017, Vol. 13 ›› Issue (03) : 261 -264. doi: 10.3877/cma.j.issn.1673-5250.2017.03.003

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叶酸受体α在妇科肿瘤临床应用的现状
刘苗1, 郝敏1,()   
  1. 1. 030001 太原,山西医科大学第二医院妇产科
  • 收稿日期:2017-01-11 修回日期:2017-05-01 出版日期:2017-06-01
  • 通信作者: 郝敏

Folate receptor alpha in clinical application of gynecologic tumor

Miao Liu1, Min Hao1,()   

  1. 1. Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2017-01-11 Revised:2017-05-01 Published:2017-06-01
  • Corresponding author: Min Hao
  • About author:
    Corresponding author: Hao Min, Email:
引用本文:

刘苗, 郝敏. 叶酸受体α在妇科肿瘤临床应用的现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2017, 13(03): 261-264.

Miao Liu, Min Hao. Folate receptor alpha in clinical application of gynecologic tumor[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2017, 13(03): 261-264.

叶酸受体(FR)是一种富含半胱氨酸的糖基磷脂酰肌醇偶联蛋白,可分为FRα、β及γ 3种亚型。其中,FRα于妇科肿瘤中的相关研究,主要集中在抗FRα抗体、FRα介导的成像技术和叶酸偶联药物靶向治疗等方面。随着对这些方面研究的不断深入,FRα作为妇科肿瘤的生物学标志物之一,愈来愈显示出较高的潜在临床价值。笔者拟就FRα在妇科肿瘤临床应用的现状进行阐述。

Folate receptors (FR) are cysteine-rich cell-surface glycoproteins, including FRα, β and γ. FRα is one of the research hotspots. Up to present, the folate depended tumours have been therapeutically and diagnostically exploited by administration of anti-FRα antibodies, FRα-targeted imaging and folate-conjugated drugs and toxins. With the deepening study, FRα as a biological marker of gynecological tumors, shows a high potential clinical value. In this review, we summarize the roles of FRα in clinical application of gynecological tumors.

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