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中华妇幼临床医学杂志(电子版) ›› 2017, Vol. 13 ›› Issue (03) : 261 -264. doi: 10.3877/cma.j.issn.1673-5250.2017.03.003

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叶酸受体α在妇科肿瘤临床应用的现状
刘苗1, 郝敏1,()   
  1. 1. 030001 太原,山西医科大学第二医院妇产科
  • 收稿日期:2017-01-11 修回日期:2017-05-01 出版日期:2017-06-01
  • 通信作者: 郝敏

Folate receptor alpha in clinical application of gynecologic tumor

Miao Liu1, Min Hao1,()   

  1. 1. Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2017-01-11 Revised:2017-05-01 Published:2017-06-01
  • Corresponding author: Min Hao
  • About author:
    Corresponding author: Hao Min, Email:
引用本文:

刘苗, 郝敏. 叶酸受体α在妇科肿瘤临床应用的现状[J]. 中华妇幼临床医学杂志(电子版), 2017, 13(03): 261-264.

Miao Liu, Min Hao. Folate receptor alpha in clinical application of gynecologic tumor[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2017, 13(03): 261-264.

叶酸受体(FR)是一种富含半胱氨酸的糖基磷脂酰肌醇偶联蛋白,可分为FRα、β及γ 3种亚型。其中,FRα于妇科肿瘤中的相关研究,主要集中在抗FRα抗体、FRα介导的成像技术和叶酸偶联药物靶向治疗等方面。随着对这些方面研究的不断深入,FRα作为妇科肿瘤的生物学标志物之一,愈来愈显示出较高的潜在临床价值。笔者拟就FRα在妇科肿瘤临床应用的现状进行阐述。

Folate receptors (FR) are cysteine-rich cell-surface glycoproteins, including FRα, β and γ. FRα is one of the research hotspots. Up to present, the folate depended tumours have been therapeutically and diagnostically exploited by administration of anti-FRα antibodies, FRα-targeted imaging and folate-conjugated drugs and toxins. With the deepening study, FRα as a biological marker of gynecological tumors, shows a high potential clinical value. In this review, we summarize the roles of FRα in clinical application of gynecological tumors.

[1]
Chen C, Ke J, Zhou XE, et al. Structural basis for molecular recognition of folic acid by folate receptors [J]. Nature, 2013, 500(7463): 486-489.
[2]
Canto MI, Setrakian S, Willis J, et al. Methylene blue-directed biopsies improve detection of intestinal metaplasia and dysplasia in Barrett′s esophagus [J]. Gastrointest Endosc, 2000, 51(5): 560-568.
[3]
Dvo?ák V, Pilka R. Role of prebioptic and bioptic methodsin the screening and diagnosis of cervical cancer[J]. Ceska Gynekol, 2014, 79(2): 88-97.
[4]
Cuzick J, Bergeron C, von Knebel Doeberitz M, et al. New technologies and procedures for cervical cancer screening[J]. Vaccine, 2012, 30(Suppl 5): F107-F116.
[5]
Ke CY, Mathias CJ, Green MA. Folate-receptor-targeted radionuclide imaging agents[J]. Adv Drug Deliv Rev, 2004, 56(8): 1143-1160.
[6]
Konda SD, Aref M, Brechbiel M, et al. Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progress[J]. Invest Radiol, 2000, 35(1): 50-57.
[7]
Meier R, Henning TD, Boddington S, et al. Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133[J]. Radiology, 2010, 255(2): 527-535.
[8]
Bhunia SK, Maity AR, Nandi S, et al. Imaging cancer cells expressing the folate receptor with carbon dots produced from folic acid[J]. Chembiochem, 2016, 17(7): 614-619.
[9]
Jia X, Li J, Wang E. One-pot green synthesis of optically pH-sensitive carbon dots with upconversion luminescence[J]. Nanoscale, 2012, 4(18): 5572-5575.
[10]
Wang L, Zhu SJ, Wang HY, et al. Common origin of green luminescence in carbon nanodots and graphene quantum dots[J]. ACS Nano, 2014, 8(3): 2541-2547.
[11]
Kelemen LE. The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?[J]. Int J Cancer, 2006, 119(2): 243-250.
[12]
Brown D, Waneck GL. Glycosyl-phosphatidylinositol-anchored membrane proteins[J]. J Am Soc Nephrol, 1992, 3(4): 895-906.
[13]
O′Shannessy DJ, Somers EB, Palmer L M, et al. Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4[J]. J Ovarian Res, 2012, 6(1): 29.
[14]
Basal E, Eghbali-Fatourechi GZ, Kalli KR, et al. Functional folate receptor alpha is elevated in the blood of ovarian cancer patients[J]. PLoS One, 2009, 4(7): e6292.
[15]
Kurosaki A, Hasegawa K, Kato T, et al. Serum folate receptor alpha as a biomarker for ovarian cancer: implications for diagnosis, prognosis and predicting its local tumor expression[J]. Int J Cancer, 2015, 138(8): 1994-2002.
[16]
Jacobs I, Bast RC Jr. The CA125 tumour-associated antigen: a review of the literature[J]. Hum Reprod, 1989, 4(1): 1-12.
[17]
Vergote IB, Marth C, Coleman RL. Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications[J]. Cancer Metastasis Rev, 2015, 34(1): 41-52.
[18]
Wang L, Wallace A, Raghavan S, et al. 6-substituted pyrrolo[2, 3-d]pyrimidine thienoyl regioisomers as targeted antifolates for folate receptor and the proton-coupled folate transporter in human tumors[J]. J Med Chem, 2015, 58(17): 6938-6959.
[19]
Amato RJ, Shetty A, Lu Y, et al. A phase Ⅰ study of folate immune therapy (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) in patients with renal cell carcinoma[J]. J Immunother, 2013, 36(4): 268-275.
[20]
Li S, Tong J, Rahman MM, et al. Oncolytic virotherapy for ovarian cancer[J]. Oncolyt Virother, 2012, 1(1): 1-21.
[21]
Sega EI, Low PS. Tumor detection using folate receptor-targeted imaging agents[J]. Cancer Metastasis Rev, 2008, 27(4): 655-664.
[22]
Despierre E, Lambrechts S, Leunen K, et al. Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy[J]. Gynecol Oncol, 2013, 130(1): 192-199.
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