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中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (03) : 344 -348. doi: 10.3877/cma.j.issn.1673-5250.2016.03.017

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综述

热休克蛋白在卵巢癌中的研究进展
邱江南1, 杨一君1   
  1. 1. 210029 南京医科大学第一附属医院妇科
  • 收稿日期:2015-12-01 修回日期:2016-04-25 出版日期:2016-06-01

Research progress of heat shock protein in ovarian cancer

Jiangnan Qiu1, Yijun Yang1   

  1. 1. Department of Gynecology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
  • Received:2015-12-01 Revised:2016-04-25 Published:2016-06-01
  • About author:
    Corresponding author: Cheng Wenjun, Email:
引用本文:

邱江南, 杨一君. 热休克蛋白在卵巢癌中的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(03): 344-348.

Jiangnan Qiu, Yijun Yang. Research progress of heat shock protein in ovarian cancer[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(03): 344-348.

热休克蛋白(HSP)是一组广泛存在于生物细胞中高度保守的蛋白质分子。由于HSP在应激反应时表达增加,故又称为应激蛋白。目前研究结果发现,HSP在多种肿瘤的发生、发展中起着重要作用。卵巢癌作为女性生殖系统常见的3大恶性肿瘤之一,其发生、发展及耐药性与HSP也存在密切关系。笔者拟通过对HSP的生物学特性及其与卵巢癌的发生、发展、化疗耐药性及治疗等方面的关系进行阐述,为卵巢癌的治疗提供依据。

Heat shock proteins (HSP), which are widely expressed in all kinds of cells, are a set of highly conserved proteins molecules. As their expressions increase under the condition of stress, they are also called stress proteins. Studies have found that HSP play an important role in the genesis and development of various tumors. As one of the three most common malignant tumors in female reproductive system, ovarian cancer has a close relationship with HSP in the tumor genesis, development and resistance to chemotherapy. This article clarifies the biological characteristics of HSP and their relationship with the genesis, development, chemoresistance and therapy of ovarian cancer, so that it can provide reference for the treatment of ovarian cancer.

1
Landriscina M, Amoroso MR, Piscazzi A, et al. Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy[J]. Gynecol Oncol, 2010, 117(2):177-182.
2
Elpek GO, Karaveli S, Simsek T, et al. Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries[J]. APMIS, 2003, 111(4):523-530.
3
Wang Q, An L, Chen Y, et al. Expression of endoplasmic reticulum molecular chaperon GRP94 in human lung cancer tissues and its clinical significance[J]. Chin Med J (Engl), 2002, 115(11):1615-1619.
4
Tanaka K, Kondoh N, Shuda M, et al. Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas[J]. Biochim Biophys Acta, 2001, 1536(1):1-12.
5
Langmár Z, Vleskó G. The potential role of heat shock proteins in the treatment of ovarian cancer[J]. Orv Hetil, 2011, 152(3):92-95.
6
张敏,刘晓民.热休克蛋白与肿瘤的研究进展[J].中华肺部疾病杂志:电子版,2013,6(6):60-62.
7
Akerfelt M, Trouillet D, Mezger V, et al. Heat shock factors at a crossroad between stress and development[J]. Ann N Y Acad Sci, 2007, 1113:15-27.
8
Samali A, Cotter TG. Heat shock proteins increase resistance to apoptosis[J]. Exp Cell Res, 1996, 223(1):163-170.
9
Tamura Y, Torigoe T, Kukita K, et al. Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity[J]. Immunotherapy, 2012, 4(8):841-852.
10
何杨.HSP27增强卵巢癌细胞对顺铂耐药的研究[D].武汉:华中科技大学,2013.
11
王宏宇.卵巢浆液性囊腺癌与交界性囊腺瘤的差异蛋白质组学分析[D].长春:吉林大学,2010.
12
李雅静,石红.HSP70与突变型P53在卵巢癌中的表达及临床意义[J].山西职工医学院学报,2012,22(5):4-8.
13
Stope MB, Koensgen D, Burchardt M, et al. Jump in the fire-heat shock proteins and their impact on ovarian cancer therapy[J]. Crit Rev Oncol Hemato, 2015, 97:152-156.
14
Bodzek P, Partyka R, Damasiewicz-Bodzek A. Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer[J]. J Ovarian Res, 2014, 7:30.
15
Kang HJ, Moon HS, Chung HW. The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer[J]. Obstet Gynecol Sci, 2014, 57(4):281-290.
16
Hoffman-Goetz L, Spagnuolo PA. Effect of repeated exercise stress on caspase 3, Bcl-2, HSP 70 and CuZn-SOD protein expression in mouse intestinal lymphocytes[J]. J Neuroimmunol, 2007, 187(1-2):94-101.
17
Vidyasagar A, Wilson NA, Djamali A. Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target[J]. Fibrogenesis Tissue Repair, 2012, 5(1):7.
18
Takeuchi K, Nakajima M, Miyazaki T, et al. Is p53 and heat shock protein 70 expression a useful parameter for preoperative hyperthermoradiation therapy in advanced rectal carcinoma[J]. Hepatogastroenterology, 2007, 54(74):367-372.
19
Akyol S, Gercel-Taylor C, Reynolds LC, et al. HSP-10 in ovarian cancer: expression and suppression of T-cell signaling[J]. Gynecol Oncol, 2006, 101(3):481-486.
20
Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, et al. Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-alpha-induced ovary cancer cell migration[J]. Arch Biochem Biophys, 2015, 571:40-49.
21
Pavan S, Musiani D, Torchiaro E, et al. HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor[J]. Int J Cancer, 2014, 134(6):1289-1299.
22
宋晓敏.分泌型热休克蛋白90α在肿瘤发生和转移中的作用机理[D].北京:清华大学,2010.
23
Elstrand MB, Stavnes HT, Trope CG, et al. Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions[J]. Hum Pathol, 2012, 43(4):529-535.
24
Song TF, Zhang ZF, Liu L, et al. Small interfering RNA-mediated silencing of heat shock protein 27 (HSP27) increases chemosensitivity to paclitaxel by increasing production of reactive oxygen species in human ovarian cancer cells (HO8910)[J]. J Int Med Res, 2009, 37(5):1375-1388.
25
Yang X, Wang J, Zhou Y, et al. Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells[J]. Cancer Lett, 2012, 321(2):137-143.
26
Milicevic ZT, Petkovic MZ, Drndarevic NC, et al. Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma-immunohistochemistry and Western blot analysis[J]. Neoplasma, 2007, 54(1):37-45.
27
Sugimura M, Sagae S, Ishioka S, et al. Mechanisms of paclitaxel-induced apoptosis in an ovarian cancer cell line and its paclitaxel-resistant clone[J]. Oncology, 2004, 66(1):53-61.
28
Afanasyeva EA, Komarova EY, Larsson LG, et al. Drug-induced Myc-mediated apoptosis of cancer cells is inhibited by stress protein Hsp70[J]. Int J Cancer, 2007, 121(12):2615-2621.
29
Yang L, Li H, Jiang Y, et al. Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells[J]. Cancer Lett, 2013, 336(1):213-221.
30
Zhao M, Ding JX, Zeng K, et al. Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?[J]. Tumour Biol, 2014, 35(2):1051-1056.
31
Calderwood SK, Murshid A, Gong J. Heat shock proteins: conditional mediators of inflammation in tumor immunity[J]. Front Immunol, 2012, 3:75.
32
Li D, Li H, Zhang P, et al. Heat shock fusion protein induces both specific and nonspecific anti-tumor immunity[J]. Eur J Immunol, 2006, 36(5):1324-1336.
33
Gong J, Zhang Y, Durfee J, et al. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use[J]. J Immunol, 2010, 184(1):488-496.
34
Yuan J, Kashiwagi S, Reeves P, et al. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma[J]. J Hematol Oncol, 2014, 7:15.
35
杨淑莉,金月梅,付莉,等.负载gp96多肽复合物的树突状细胞抗耐药卵巢癌细胞株作用的实验研究[J].中国妇幼保健,2008,23(33):4759-4762.
36
Olejek A, Damasiewicz-Bodzek A, Bodzek P, et al. Concentrations of antibodies against heat shock protein 27 in the sera of women with ovarian carcinoma[J]. Int J Gynecol Cancer, 2009, 19(9):1516-1520.
37
Zhang Z, Xie Z, Sun G, et al. Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells[J]. Int J Clin Exp Med, 2015, 8(5):6687-6701.
38
Han FF, Li L, Shang BY, et al. Hsp90 inhibitor geldanamycin enhances the antitumor efficacy of enediyne lidamycin in association with reduced DNA damage repair[J]. Asian Pac J Cancer Prev, 2014, 15(17):7043-7048.
39
孙广宇.格尔德霉素及其顺铂联合应用对人卵巢癌细胞SKOV3及SKOV3/DDP耐药性影响的研究[D].石家庄:河北医科大学,2012.
40
Oude Munnink TH, Korte MA, Nagengast WB, et al. 89Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft[J]. Eur J Cancer, 2010, 46(3):678-684.
41
Vesci L, Milazzo FM, Carollo V, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor[J]. Int J Oncol, 2014, 45(4):1421-1429.
42
Li W, Wang W, Dong H, et al. Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78[J]. Oncol Rep, 2014, 31(6):2525-2534.
43
Elstrand MB, Kleinberg L, Kohn EC, et al. Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma[J]. Int J Gynecol Pathol, 2009, 28(3):211-221.
44
Lv Q, Sun H, Cao C, et al. Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1) are associated with poor prognosis of epithelial ovarian cancer[J]. Tumour Biol, 2016, 37(2):2721-2727.
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