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中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (01) : 88 -91. doi: 10.3877/cma.j.issn.1673-5250.2016.01.016

所属专题: 文献

综述

微小RNA-203在宫颈癌调控机制作用的研究进展
高雅茹1, 赵卫红1   
  1. 1. 030001 太原,山西医科大学第二医院
  • 收稿日期:2015-06-03 修回日期:2015-08-26 出版日期:2016-02-01

Research progress of regulation mechanism of microRNA-203 in cervical cancer

Yaru Gao1, Weihong Zhao1   

  1. 1. Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2015-06-03 Revised:2015-08-26 Published:2016-02-01
  • About author:
    Corresponding author: Hao Min, Email:
引用本文:

高雅茹, 赵卫红. 微小RNA-203在宫颈癌调控机制作用的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(01): 88-91.

Yaru Gao, Weihong Zhao. Research progress of regulation mechanism of microRNA-203 in cervical cancer[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(01): 88-91.

宫颈癌是发展中国家女性最常见的恶性肿瘤之一,为导致女性死亡的主要原因之一。目前已在宫颈癌中发现多种微小RNA(miRNA)表达异常。miRNA-203为上皮特异性miRNA,作为抑癌因子参与宫颈癌的发生、发展。miRNA-203在宫颈癌增殖、侵袭、迁移及凋亡等肿瘤生物学特性中,扮演重要角色。近年关于miRNA-203在恶性肿瘤调控机制中作用的研究日益增多。最新研究表明,miRNA-203在宫颈癌的表达受DNA甲基化、人乳头状瘤病毒(HPV)蛋白、转录因子等上游机制调控,并通过调控下游靶蛋白而发挥其抑癌作用。笔者拟就miRNA-203的生物学功能及其在宫颈癌调控机制中的作用研究进展进行综述如下。

Cervical cancer is one of the most frequent malignancies among women in most developing countries. Cervical cancer is one of the primary causes of female death worldwide. Previous reports have shown that lots of microRNAs (miRNA) are abnormally expressed in cervical cancer. miRNA-203, an epithelial-specific miRNA, is involved in the tumorigenesis and progression of cervical cancer and acts as a tumor suppressor, which plays an important role in the regulation of the proliferation, migration, invasion and apoptosis of cervical cancer. The mechanism leading to the aberrant expression of miRNA-203 has been a hot spot in the research of miRNA recently. Recent studies have shown that its expression is regulated by DNA methylation, human papillomavirus (HPV) protein, transcription factor and it regulates the expression of target genes. Here is to make a review on the research progress of miRNA-203 in the biological function and the regulation mechanisms of cervical cancer.

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