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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (06) : 833 -836. doi: 10.3877/cma.j.issn.1673-5250.2013.06.028

所属专题: 文献

综述

mTOR信号通路及其在宫颈癌研究中的进展
冯倩倩1   
  1. 1. 225001 江苏,扬州大学临床医学院妇产科
  • 收稿日期:2013-09-01 修回日期:2013-11-02 出版日期:2013-12-01

mTOR Signaling Pathway and Its Research Progress in Cervical Cancer

Qian-qian FENG1   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medicine College, Yangzhou University, Yangzhou 225001, Jiangsu Province , China
  • Received:2013-09-01 Revised:2013-11-02 Published:2013-12-01
  • About author:
    (Corresponding author : LU Dan,Email : )
引用本文:

冯倩倩. mTOR信号通路及其在宫颈癌研究中的进展[J]. 中华妇幼临床医学杂志(电子版), 2013, 09(06): 833-836.

Qian-qian FENG. mTOR Signaling Pathway and Its Research Progress in Cervical Cancer[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(06): 833-836.

哺乳动物雷帕霉素靶蛋白(mTOR)信号通路由于处于生长调节的中心环节而倍受关注,其在细胞生长、增殖、分化及细胞周期调控等多个方面起到重要作用。mTOR信号通路复杂且涉及广泛,其中多个元素的调控异常均与肿瘤的发生密切相关。近年来研究显示,宫颈癌中mTOR信号通路过度表达,表明宫颈癌的发生发展与mTOR信号通路存在紧密内在联系。这可为寻找阻断此通路的特异性靶向治疗药物提供依据。但其具体机制仍需深入研究。本文就mTOR信号转导通路的组成与功能、调节及其与宫颈癌发生发展的相关性进行综述。

Mammalian target of rapamycin (mTOR) signaling pathway is in the central part of the growth regulating that has received increasing concern. It is centrally involved in control of cell growth, proliferation, differentiation and cell cycle regulation. Complicated and the dysregulation of mTOR pathway is recognized to be associated with lots of tumors. Recent studies have found that mTOR signaling pathway express excessively in cervical cancer,which indicates that the occurrence and development of cervical cancer has close inner link with mTOR signaling pathway. It also provides the basis for searching the specific targeted therapy drugs to block this pathway, but the specific mechanism still needs further study. In this treatise,the author summarizes the development of researches on the composition, function and regulation of mTOR signaling pathway and its correlation with the development of cervical carcinoma.

1
Samuels Y, Waldman T. Oncogenic mutations of PIK3CA in human cancers[J]. Curr Top Microbiol Immunol,2010 ,347 :21-41.
2
Jacinto E, Loewith R, Schmidt A,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive[J]. Nat Cell Biol,2004,6: 1122-1128.
3
Dufner A, Thomas G. Ribosomal S6 kinase signaling and the control of translation[J]. Exp Cell Res, 1999 ,25 : 100-109.
4
Bartholomeusz C, Gonzalez-Angulo AM. Targeting the PI3K signaling pathway in cancer therapy[J]. Expert Opin Ther Targets, 2012,16(1):121-130.
5
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease[J]. Nat Genet,2005,37:19-24.
6
Cozzone D, Fröjdö S, Disse E, et al. Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients[J]. Diabetologia,2008,51 (3):512-521.
7
Adjei AA, Hidal M. Intracellular signal transduction pathway proteins as targets for cancer therapy [J]. J Clin Oncol, 2005, 23 : 5386-5403.
8
Canto C, Jiang L Q, Deshmukh AS,et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle[J]. Cell Metab,2010,11(3) :213-219.
9
Kim SA, Choi HC. Metformin inhibits inflammatory response via AMPK-PTEN? pathway in vascular smooth muscle cells [J]. Biochem Biophys Res Commun,2012,425(4) :866-872.
10
Steelman LS, Abrams SL, Whelan J, et al. Contributions of the Raf/MEK/ERK, PI3K/ PTEN/AKT/mTOR and Jak/STAT pathways to leukemia[J]. Leukemia,2008,22(4) : 686-707.
11
Carter BZ, Milella M, Altieri DC, el al. Cytokine-regulated expression of survivin in myeloid leukemia[J], Blood,2001,97 (9): 2784-2790.
12
Guo Q, Li Y. Research on the expression of Survivin and PTEN in laryngeal squamous cell carcinoma transplanted on the back sides of nude mice treated by gold throat tablets[J]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2012,26(24) : 1134-1137.
13
Yan J, Zhou H, Kong L,et al. Identification of two novel inhibitors of mTOR signaling pathway based on high content screening[J]. Cancer Chemother Pharmacol.,2013,23 (10) : 123-127.
14
Choe G, Horvath S, Clouqhesy TF, et al. Analysis of the phosphatidylinositol 3'-kinase signaling pathyway in glioblastoma patients in vivo[J]. Cancer Res,2003,63(12) : 2742-2746.
15
Neve RM, Horvath S, Hynes NE. Distinct roles for phosphoinostide 3-kinase,mitogen-activated protein kinase and P38 MAPK in mediating cell cycle progression of breast cancer cells[J]. Oncoqene,2002,21:4567-4576.
16
Philp AJ, Campbell IG, Leet C, et al. The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors[J]. Cancer Res,2001,61 : 7426-7429.
17
Welker ME, Kulik G. Recent syntheses ofPI3K/Akt/mTOR signaling pathway inhibitors[J]. Bioorg Med Chem, 2013 ,21(14): 4063-4091.
18
Korets SB, Czok S, Blank SV. Targeting the mTOR/4E-BP pathway in endometrial cancer[J]. Clin Cancer Res, 2011,17(24): 7518-7528.
19
Pratheeshkumar P, Budhraja A. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways[J]. PLoS One, 2012,7(10):331-336.
20
Cantley LC, Neel BG. New insights into tumor suppression:PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway[J]. Proc Natl Acad Sci USA, 1999, 96 (8): 4240-4245.
21
Chen X, Wang Y, Luo H. β-elemene acts as an antitumor factor and down regulates the expression of survivin, Bcl-xL and Mta-1 [J]. Mol Med Rep,2012,6(5) :989-995.
22
Heselmeyer K, Schrock E, du Manoir S,et al. Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix[J]. Proc Natl Acad Sci USA, 1996,93(1) :479-484.
23
Shayesteh L, LuY, Kuo WL, et al. PIK3CA is implicated as oncogene in ovarian cancer[J]. Nat Genet,1999,21 (1): 99-102.
24
Ji J, Gu TT, Zheng PS. The expression and clinical significanceof mTOR/ P70S6K signaling pathway in cervical cancer [J]. J Xi'an Jiaotong Univ:Med Sci,2010,31(1) : 10-13.
25
Chen YJ, Liu J, Tao YJ, et al. Expression of PTEN, PI3K, mTOR in nasopharyngeal carcinoma and their significance[J]. Mod Oncol, 2009,17(1):41-43.
26
Nathan CO, Amirghahari N, Rong X, et al. Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer [J]. Cancer Res,2007,67(5) :2160-2168.
27
Xia BR, Meng FL, Lu BY. The expression and clinical significance of mTOR,Eie4e,4E-BP1 in cervical cancer [J]. Pract Oncol J, 2011,25(4):301-305.
28
Rizvi MM, Alam MS, Ali A,et al. Aberrant promoter methylation and inactivation of PTEN gene in cervical carcinoma from Indian population[J]. J Cancer Res Clin Oncol,2011,137(8) : 1255-1262.
29
Lu D, Qian J, Yin X, et al. Expression of PTEN and survivin in cervical cancer:Promising biological markers for early diagnosis and prognostic evaluation[J]. Br J Biomed Sci,2012,69(4) : 143-146.
30
Wen ZF, Fan HJ, Zhang HJ. The expression and significance of p-PKB and PTEN in cervical cancer [J]. Med Inform, 2011, 24 (2): 961-963.
31
Zhu H, Shi ZZ, Yang XJ, et al. The Expression and clinical significance of survivin,Bcl-2 and HPV16/18 in cervical intraepithelial neoplasia and cervical cancer[J]. J Pract Obstet Gynecol,2010,26(1) :57-60.
32
Yu J, Wang DH. The expression of survivin and PTEN in cervical cancer and associated research [J]. J Tianjin Med Univ, 2011, 17 (2):240-242.
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