切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (06) : 828 -832. doi: 10.3877/cma.j.issn.1673-5250.2013.06.027

所属专题: 文献

综述

子宫内膜异位症相关卵巢癌的临床诊治进展
马志华1, 吕东昊1   
  1. 1. 610041 成都四川大学华西第二医院妇产科
  • 收稿日期:2013-08-20 修回日期:2013-11-22 出版日期:2013-12-01

Advances for the Clinical Diagnosis and Treatment of Endometriosis-Associated Ovarian Cancer

Zhi-hua MA1, Dong-hao LU1   

  1. 1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province , China
  • Received:2013-08-20 Revised:2013-11-22 Published:2013-12-01
  • About author:
    (Corresponding author : SHI Gang, Email : )
引用本文:

马志华, 吕东昊. 子宫内膜异位症相关卵巢癌的临床诊治进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2013, 09(06): 828-832.

Zhi-hua MA, Dong-hao LU. Advances for the Clinical Diagnosis and Treatment of Endometriosis-Associated Ovarian Cancer[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(06): 828-832.

子宫内膜异位症(EMs)是最常见的妇科疾病之一,于育龄期妇女中的发病率为10%~15%。流行病学研究表明,EMs增加了上皮性卵巢癌的发生风险,尤其是子宫内膜样癌和侵袭性透明细胞癌的发生风险。目前关于EMs相关卵巢癌(EAOC)的病因和发病机制的研究尚未阐明。研究认为,EAOC可能与肝细胞核因子(HNF)-ARID1A等基因的突变及氧化应激等有关。EAOC在发现时多处于早期,临床表现无特异性。MRI诊断EAOC具有较高的特异性和灵敏度,但该病的最终确诊主要依靠组织病理学检查。在EAOC治疗方面,目前主要采取以手术治疗辅以术后化疗,而靶向治疗、早期预防治疗同样重要。EAOC一旦确诊应尽早手术,由于其具有易复发的特点,术后密切随访是必要的。EAOC的化疗目前多主张采用紫杉醇加铂类,但效果不理想。目前研究发现,EAOC较无EMs的卵巢癌(OC)有更好的预后。

Endometriosis (EMs) is one of the most common gynecological diseases, its incidence rate about 10%-15% of all pre-menopausal women. Epidemiological studies had shown that EMs increases the risk of development of ovarian cancer(OC),especially endometrioid and invasive clear cell carcinoma. The etiology and pathogenesis of endometriosis-associated ovarian cancer(EAOC) is not yet clear, which may associated with the hepatocyte nuclear factor (HNF)- or ARID1A gene mutations and oxidative stress, etc. EAOC mostly was diagnosed in the early stage which has non-specific clinical manifestations. EAOC, which confirmed diagnosis is histopathological examination, has high specificity and sensitivity in MRI. In the treatment, presently take performed surgery and supplemented by postoperative chemotherapy as the principal thing. It's targeted therapy and early prevention are equally important. Once EAOC is diagnosed, surgery should be performed as soon as possible. What's more, due to easily recurrence,close follow-up is necessary after the surgery. Currently in chemotherapy paclitaxel plus platinum-based was advocated,but the effect is not ideal. Recent studies showed that EAOC have a better prognosis than ovarian cancer without EMs.

1
Pearce CL, Templeman C, Rossing MA, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies [J]. Lancet Oncology, 2012,13(4) : 385-394.
2
Gazvani R, Templeton A. New considerations for the pathogenesis of endometriosis [J]. Int J Gynecol Obstet, 2002,76(2): 117-126.
3
Halme J, Hammond MG, Hulka JF. Retrograde menstruation in healthy women and in patients with endometriosis [J]. Obstet Gynecol, 1984, 64, 151-154.
4
Halme J, Hammond MG, Hulka JF, et al. Retrograde menstruation in healthy women and in patients with endometriosis [J]. Obstetrics Gynecology, 1984, 64(2): 151-154.
5
Pearce CL, Templeman C, Rossing MA, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies [J]. Lancet Oncology, 2012,13(4) : 385-394.
6
Kondi-Pafiti A, Papakonstantinou E, Iavazzo C, et al. Clinicopathological characteristics of ovarian carcinomas associated with endometriosis[J]. Arch Gynecol Obstet, 2012,285(2) : 479-483.
7
Pergialiotis V, Lagkadas A, Polychronis O, et al. Endometriosisassociated ovarian cancer. Presentation of a case report and review of the literature[J]. Eur J,2011,32(6) : 2011,334-337.
8
Boyd J, Sonoda Y, Federici MG, et al. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer [J]. JAMA, 2000, 283(17): 2260-2265.
9
Kobayashi H. Ovarian cancer in endometriosis: Epidemiology, natural history, and clinical diagnosis[J]. Int J Clin Oncol, 2009, 14(5): 378-382.
10
Kato N, Sasou S, Motoyama T. Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary[J]. Mod Pathol, 2005,19(1) : 83-89.
11
Dinulescu DM, Ince TA, Quade BJ, et al. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer[J]. Nature Med, 2004, 11(1): 63-70.
12
Yamamoto S, Tsuda H, Takano M, et al. Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations[J]. Mod Pathol, 2011,25(4) : 615-624.
13
Wiegand KC, Shah SP, Al-Agha OM, et al. ARID1A mutations in endometriosis-associated ovarian carcinomas [J]. New Eng J Med, 2010, 363(16): 1532-1543.
14
Chou YC, Chen YJ, Lai CR, et al. Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis [J]. Eur J Obstet Gynecol Reprod Biol, 2006,124(1) : 101-105.
15
Keita M, Bessette P, Pelmus M,et al. Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes [J]. J Ovarian Res,2010,3 (1): 1757-2215.
16
Hayrabedyan S, Mourdjeva M, Kyurkchiev S, et al. Mmunofluorescent localization of I1-1α,FGF-1,S100A13 as angiogenic factors and a specific ovarian cancer marker (ovac) in endometriosis[J]. Clin Applicat Immunol, 2004,3(1): 310-315.
17
Yamaguchi K, Mandai M, Toyokuni S,et al. Contents of endometriotic cysts,especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the ironinduced persistent oxidative stress[J]. Clin Cancer Res,2008,14 (1): 32-40.
18
Kobayashi H, Ooi H, Yamada Y, et al. Serum CA125 level before the development of ovarian cancer [J]. Int J Gynecol Obstet, 2007,99(2) : 95-99.
19
Tanaka YO, Yoshizako T, Nishida M,et al. Ovarian carcinoma in patients with endometriosis mr imaging findings [J]. Am J Roentgenol, 2000,175(5) : 1423-1430.
20
Sampson JA. Endometrial carcinoma of the ovary, arising in endometrial tissue in that organ[J]. Archiv Surg, 1925,10(1) : 1-2.
21
Scott B. Malignant changes in endometriosis[J]. Obstet Gynecol, 1953,2(3) : 283-289.
22
Lee KR, Nucci MR. Ovarian mucinous and mixed epithelial carcinomas of mullerian (endocervical-like) type : A clinicopathologic analysis of four cases of an uncommon variant associated with endometriosis[J]. Int J Gynecol Pathol,2003,22 (1): 42-51.
23
Satoh T, Hatae M, Watanabe Y,et al. Outcomes of fertility-sparing surgery for stage I epithelial ovarian cancer: A proposal for patient selection[J]. J Clin Oncol, 2010,28(10) : 1727-1732.
24
Seidman JD, Kurman RJ. Treatment of micropapillary serous ovarian carcinoma (the aggressive variant of serous borderline tumors)[J]. Cancer, 2002,95(4) : 675-676.
25
Prospect of drugs in the treatment of endometriosis[J/CD]. Chin J Obstet Gynecol Pediatr:Electron Ed, 2008,4(3) : 234-238.
26
Kumar S, Munkarah A, Arabi H, et al. Prognostic analysis of ovarian cancer associated with endometriosis [J]. Am J Obstet Gynecol, 2011,204(1) : 63. el-e3,e7.
27
Takano M, Kikuchi Y, Yaegashi N,et al. Clear cell carcinoma of the ovary : A retrospective multicentre experience of 254 patients with complete surgical staging[J]. Br J Cancer, 2006,94(10): 1369-1374.
[1] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[2] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[3] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[4] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[5] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[6] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[7] 刘柏隆, 周祥福. 压力性尿失禁阶梯治疗的项目介绍[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 125-125.
[8] 刘柏隆. 女性压力性尿失禁阶梯治疗之手术治疗方案选择[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 126-126.
[9] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[10] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[11] 陈杰, 武明胜, 李一金, 李虎, 向源楚, 荣新奇, 彭健. 低位直肠癌冷冻治疗临床初步分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 494-498.
[12] 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845.
[13] 王景明, 王磊, 许小多, 邢文强, 张兆岩, 黄伟敏. 腰椎椎旁肌的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 846-852.
[14] 崔军威, 蔡华丽, 胡艺冰, 胡慧. 亚甲蓝联合金属定位夹及定位钩针标记在乳腺癌辅助化疗后评估腋窝转移淋巴结的临床应用价值探究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 625-632.
[15] 王誉英, 刘世伟, 王睿, 曾娅玲, 涂禧慧, 张蒲蓉. 老年乳腺癌新辅助治疗病理完全缓解的预测因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 641-646.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?