切换至 "中华医学电子期刊资源库"
高级检索
中华妇幼临床医学杂志(电子版)

中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (03) : 357 -360. doi: 10.3877/cma.j.issn.1673-5250.2013.03.017

所属专题： 文献；

论著

维生素D受体基因BsmⅠ位点多态性与儿童1型糖尿病发生的Meta分析
王凌飞1,*,*(), 张耀东1, 卫海燕1   
  1. 1. 450052　郑州，郑州市儿童医院内分泌科
  • 收稿日期:2013-02-25 修回日期:2013-05-15 出版日期:2013-06-01
  • 通信作者: 王凌飞

Relationship Between BsmⅠ Vitamin D Receptor Gene Polymorphism and Childhood Type 1 Diabetes Mellitus: A Meta-Analysis

Ling-fei WANG1(), Yao-dong ZHANG1, Hai-yan WEI1   

  1. 1. Department of Endocrinology, Zhengzhou Children's Hospital, Zhengzhou 450052, Henan Province, China
  • Received:2013-02-25 Revised:2013-05-15 Published:2013-06-01
  • Corresponding author: Ling-fei WANG
  • About author:
    (Corresponding author: WANG Ling-fei, Email: )
全文 ( ) 下载PDF ( ) 导出引用
引用本文：

王凌飞, 张耀东, 卫海燕. 维生素D受体基因BsmⅠ位点多态性与儿童1型糖尿病发生的Meta分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2013, 09(03): 357-360.

Ling-fei WANG, Yao-dong ZHANG, Hai-yan WEI. Relationship Between BsmⅠ Vitamin D Receptor Gene Polymorphism and Childhood Type 1 Diabetes Mellitus: A Meta-Analysis[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(03): 357-360.

目的

评价维生素D受体(VDR)基因BsmⅠ位点多态性与儿童1型糖尿病(T1DM)的相关性。

方法

自行制定检索策略：以"VDR"，"vitamin D receptor"，"T1DM"，"type 1 diabetes mellitus"，"gene polymorphism"等为检索词(不区分大小写)，检索PubMed，Cochrane Library，EMbase，Springer和Ovid数据库；以"1型糖尿病"、"T1DM"、"维生素D受体基因"、"多态性"、"儿童"等为检索词，检索中国学术期刊全文数据库[清华同方(CNKI)]、中国生物医学文献数据库(CBM)和万方数据库中的对照研究文献。检索时间为建库至2010年9月20日。对检索到的相关参考文献进行手工搜索。采用RevMan 5.1版统计学软件对VDR基因BsmⅠ位点基因型在儿童T1DM组与对照组中是否有差异进行Meta分析。

结果

按照检索策略共检索出符合条件的文献为7篇，T1DM组共纳入患者为948例，对照组为1055例。根据各项研究异质性检验结果，利用固定效应模型对VDR基因BsmⅠ位点的Bb，bb，Bb＋bb基因型与T1DM相关性进行Meta分析，各项研究的合并优势比(OR)值(95%CI)结果分别为0.68(0.48～0.96)、0.64(0.47～0.88)和0.63(0.48～0.82)。

结论

VDR基因BsmI位点多态性可降低儿童T1DM发生。

关键词: Meta分析, 维生素D受体基因, 1型糖尿病, 基因多态性, 儿童
Objective

To explore the correlation of BsmⅠ vitamin D receptor (VDR) gene polymorphism and type 1 diabetes mellitus(T1DM) in children.

Methods

Taking"VDR","vitamin D receptor","T1DM","type 1 diabetes mellitus","gene polymorphism"as the key words, We searched PubMed, Cochrane Library, EMbase, Springer, Ovid, Chinese Journal Full-text Database (CNKI), China Biology Medicine (CBM) and Wanfang Data to collected all the publications about the correlation between BsmⅠ VDR gene polymorphism and T1DM in children. Meta-analysis was performed for checking the difference between two groups about genotypes such as Bb, bb, Bb+ bb by Revman 5.1 software.

Results

A total of 7 studies involving 948 T1DM children and 1055 healthy children were included in the Meta-analysis.According to the heterogeneity test results of these studies, pooled OR value(95%CI) of Meta-analysis of Bb, bb, Bb+ bb genotype of BsmⅠ VDR gene polymorphism by fixed effect model were 0.68(0.48-0.96), 0.64(0.47-0.88) and 0.63 (0.48-0.82).

Conclusions

This Meta-analysis demonstrates the correlation between BsmⅠ VDR gene polymorphism and T1DM in children.

Key words: Meta-analysis, vitamin D receptor, type 1 diabetes mellitus, gene polymorphism, child
表1 7篇纳入文献的基本资料
Table 1 General data of seven included studies
纳入文献 发表时间(年) 来源国家 T1DM组基因型 对照组基因型 NOS评分
n BB Bb bb n BB Bb bb
Chang等[6] 2000 中国台湾 157 4 16 137 248 1 16 231 8
García等[7] 2007 智利 216 21 110 77 203 14 74 115 7
Gy?rffy等[8] 2002 匈牙利 107 17 53 35 103 18 44 40 6
Mory等[9] 2009 巴西 189 60 57 60 194 38 74 70 7
Panierakis等[10] 2009 希腊 96 38 43 15 100 23 57 20 8
San-Pedro等[11] 2005 西班牙 71 15 40 16 88 17 44 27 8
Skrabi?等[12] 2003 克罗地亚 134 24 58 52 132 17 74 41 7
图1 VDR基因BsmⅠ位点Bb基因型与儿童T1DM的关系
Figure 1 Relationship of Bb genotype of BsmⅠ VDR gene polymorphism and susceptibility to type 1 diabetes
图2 VDR基因BsmⅠ位点bb基因型与儿童T1DM的关系
Figure 2 Relationship of bb genotype of BsmⅠ VDR gene polymorphism susceptibility to type 1 diabetes
图3 VDR基因BsmⅠ位点Bb＋bb基因型与儿童T1DM的关系
Figure 3 Relationship of Bb＋bb genotype of BsmⅠ VDR gene polymorphism susceptibility to type 1 diabetes
表2 两种效应模型对Bb，bb，Bb＋bb基因型的OR值及其95%CI比较
Table 2 Comparison of OR value(95%CI) of Bb，bb，Bb＋bb genotype between two effect models
基因型 随机效应模型 固定效应模型
OR值 95%CI OR值 95%CI
Bb 0.66 0.50～0.87 0.68 0.49～0.96
bb 0.64 0.47～0.87 0.64 0.47～0.88
Bb＋bb 0.62 0.48～0.80 0.63 0.48～0.82
[1]
Yang JJ, Zhang YH, Huo ZH, et al.An analysis on susceptible genes polymorphism of insulin dependent diabetes mellitus in children in Ningxia[J].J Ningxia Med Col, 2006, 28:374-378.
[2]
Benmansour J, Stayoussef M, Al-Jenaidi FA, et al. Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians[J].Clin Vaccine Immunol, 2010, 17:1473-1477.
[3]
Pani MA, Knapp M, Donner H, et al. Vitamin D receptor allele combinations influence genetic susceptibility to type I diabetes in Germans[J]. Diabetes, 2000, 49:504-507.
[4]
Angel B, Santos JL, Carrasco E, et al.Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in Chilean subjects:A case-parent study[J]. Eur J Epidemiol, 2004, 19:1085-1087.
[5]
Wu HQ.Analysis of danger factors related with insulin-dependent diabetes mellitus in children[J].Chin J Child Health Care, 2006, 14:250-252.
[6]
Chang TJ, Lei HH, Yeh JI, et al.Vitamin D receptor gene polymorphisms influence susceptibility to type I diabetesmellitus in the Taiwanese population[J]. Clin Endocrinol, 2000, 52:575-580.
[7]
Györffy B, Vásárhelyi B, Krikovszky D, et al.Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus[J].Eur J Endocrinol, 2002, 147:803-808.
[8]
San-Pedro JI, Bilbao JR, Perez de Nanclares G, et al.Heterogeneity of vitamin D receptor gene association with celiac disease and type 1 diabetes mellitus[J]. Autoimmunity, 2005, 38:439-444.
[9]
Mory DB, Rocco ER, Miranda WL, et al.Prevalence of vitamin D receptor gene polymorphisms FokI and BsmI in Brazilian individuals with type 1 diabetes and their relation to beta-cell autoimmunity and to remaining beta-cell function[J].Hum Immunol, 2009, 70:447-451.
[10]
García D, Angel B, Carrasco E, et al.VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile[J].Diabetes Res Clin Pract, 2007, 77:134-140.
[11]
Panierakis C, Goulielmos G, Mamoulakis D, et al.Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece[J].Clin Immunol, 2009, 133):276-281.
[12]
Skrabić V, Zemunik T, Situm M, et al.Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population[J].Diabetes Res Clin Pract, 2003, 59:31-35.
[13]
Bjornvold M, Undlien DE, Joner G, et al. Joint effects of HLA, INS, PTPN22 and CTLA-4 genes on the risk of type 1 diabetes[J].Diabetologia, 2008, 51:589-596.
[14]
Zhang WW, Sheng ZY, Wang YF.Analysis of relationship of Vitamin D and its receptor gene polymorphism and susceptibility to type 1 diabetes[J]. Clin Med China, 2006, 22:953-954.
[15]
Motohashi Y, Yamada S, Yanagawa T, et al. Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes[J]. J Clin Endocrinol Metab, 2003, 88:3137-3140.
[16]
McDermott MF, Ramachandran A, Ogunkolade BW, et al. Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians[J]. Diabetologia, 1997, 40:971-975.
[1] 陶宏宇, 叶菁菁, 俞劲, 杨秀珍, 钱晶晶, 徐彬, 徐玮泽, 舒强. 右心声学造影在儿童右向左分流相关疾病中的评估价值[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(10): 959-965.
[2] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[3] 向韵, 卢游, 杨凡. 全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 569-574.
[4] 王雅楠, 刘丹, 曹正浓, 贾慧敏. 儿童迟发性先天性膈疝患儿的临床诊治特点分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 410-419.
[5] 张梦思, 麻艺群, 蒙礼娟, 朱辉, 付晋凤. 压力手套与指蹼加压带及泡沫型硅凝胶贴膜联合应用于儿童瘢痕性并指术后的效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 329-334.
[6] 郑宝英, 黄小兰, 贾楠, 朱春梅. 儿童难治性肺炎支原体肺炎早期预警指标[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 215-221.
[7] 刘冉佳, 崔向丽, 周效竹, 曲伟, 朱志军. 儿童肝移植受者健康相关生存质量评价的荟萃分析[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 302-309.
[8] 丁荷蓓, 王珣, 陈为国. 七氟烷吸入麻醉与异丙酚静脉麻醉在儿童腹股沟斜疝手术中的应用比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 570-574.
[9] 曾纪晓, 徐晓钢, 王欣星, 刘斐, 兰梦龙, 陶波圆, 梁子建, 叶志华, 罗媛圆. 达芬奇机器人辅助Swenson-like巨结肠根治术[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(04): 239-243.
[10] 中华医学会器官移植学分会, 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式供肝儿童肝移植中国临床操作指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 593-601.
[11] 刘军, 丘文静, 孙方昊, 李松盈, 易述红, 傅斌生, 杨扬, 罗慧. 在体与离体劈离式肝移植在儿童肝移植中的应用比较[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 688-693.
[12] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[13] 王晓瑜, 郭群英, 牛雅萌, 赵成松. 公立儿童医院促进儿科就医均等化实践探析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 383-387.
[14] 陈晓胜, 何佳, 刘方, 吴蕊, 杨海涛, 樊晓寒. 直立倾斜试验诱发31 秒心脏停搏的植入心脏起搏器儿童一例并文献复习[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 488-494.
[15] 曹亚丽, 高雨萌, 张英谦, 李博, 杜军保, 金红芳. 儿童坐位不耐受的临床进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 510-515.
阅读次数
全文


摘要

版权所有 中华医学会 中华医学电子音像出版社有限责任公司  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号