儿童缺血性脑血管病急性期血清同型半胱氨酸水平变化研究

doi:10.3877/cma.j.issn.1673-5250.2013.03.011

中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (03) : 330 -332. doi: 10.3877/cma.j.issn.1673-5250.2013.03.011

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儿童缺血性脑血管病急性期血清同型半胱氨酸水平变化研究

郑秀霞¹^,^*^,^*(

), 袁向东¹

^1. 476100　河南商丘，商丘市第一人民医院

收稿日期:2013-01-10 修回日期:2013-04-03 出版日期:2013-06-01
通信作者: 郑秀霞

Levels of Serum Homocysteine in Children With Acute Ischemic Cerebrovascular Diseases

Xiu-xia ZHENG¹(), Xiang-dong YUAN¹

^1. Department of Laboratory, First People's Hospital of Shangqiu City, Shangqiu 476100, Henan Province, China

Received:2013-01-10 Revised:2013-04-03 Published:2013-06-01
Corresponding author: Xiu-xia ZHENG
About author:
(Corresponding author: ZHENG Xiu-xia, Email: yuanxiangdong6668@ sina.com)

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目的

探讨儿童缺血性脑血管病血清同型半胱氨酸(Hcy)的水平变化。

方法

选择2007年1月至2011年8月于本院儿科就诊的儿童缺血性脑血管病急性期患儿30例为研究对象纳入研究组。随机选择同期在本院健康体检的健康儿童30例纳入对照组。对两组受试儿童采用循环酶法测定儿童缺血性脑血管病急性期Hcy水平，并进行统计学分析(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。两组受试者年龄、性别等临床资料比较，差异均无统计学意义(P>0.05)。

结果

研究组男性与女性儿童的血清Hcy水平分别显著高于对照组同性别儿童[(28.11±10.98) μmol/L vs. (11.36±5.43)μmol/L; (22.96±11.26) μmol/L vs.(12.15±4.33)μmol/L]，差异有统计学意义(t＝12.87，10.67；P<0.01)；两组受试者血清Hcy异常检出率比较，差异亦有统计学意义(χ²＝12.319，P<0.01)。

结论

儿童缺血性脑血管病急性期血清Hcy水平显著升高、异常检出率较高。Hcy水平变化可能在该病的发生发展中起重要作用。

关键词: 缺血性脑血管病, 同型半胱氨酸, 儿童

Objective

To investigate the clinical significance of serm homocysteine(Hcy) levels in children with acute ischemic cerebrovascular diseases.

Methods

From January 2007 to August 2011, a total of 30 children with acute ischemic cerebrovascular were recruited as study group. Meanwhile another 30 healthy children who took physical examination in our hospital were included into control group. Levels of Hcy were measured by cycling enzymatic method in both groups children and analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First People's Hospital of Shangqiu City. Informed consent was obtained from the parents of each participating child. There had no significance difference between two groups among gender, age and others general clinical data(P>0.05).

Results

Levels of Hcy between boys and girls in study group were much higher than those in control group, respectively [(28.11±10.98) μmol/L vs. (11.36±5.43)μmol/L; (22.96±11.26) μmol/L vs. (12.15±4.33)μmol/L] (P<0.05). There had significance difference between two groups in abnormal rates in levels of Hcy (P<0.05), too.

Conclusions

Hcy may plays an important role in the mechanism of ischemic cerebrovascular diseases in children.

Key words: ischemic cerebrovascular diseases, homocysteine, child

表1 两组受试者血清同型半胱氨酸水平比较(±s，μmol/L)

Table 1 Comparison of serum levels of homocysteine between two groups(±s，μmol/L)

组别		n	Hcy水平	t	P
研究组		30
	男性	17	28.11±10.98^a	12.87	<0.01
	女性	13	22.96±11.26^a	10.67	<0.01
对照组		30
	男性	18	11.36±5.43
	女性	12	12.15±4.33

表1 两组受试者血清同型半胱氨酸水平比较(±s，μmol/L)

Table 1 Comparison of serum levels of homocysteine between two groups(±s，μmol/L)

组别		n	Hcy水平	t	P
研究组		30
	男性	17	28.11±10.98^a	12.87	<0.01
	女性	13	22.96±11.26^a	10.67	<0.01
对照组		30
	男性	18	11.36±5.43
	女性	12	12.15±4.33

表2 两组受试者血清同型半胱氨酸异常检出率比较[n(%)]

Table 2 Comparison of abnormal rates of serum levels of homocysteine between two groups[n(%)]

组别		n	异常检出率	χ²	P
研究组		30	25(83.3)^a	52.5	<0.005
	男性	17	16(94.1)
	女性	13	12(92.3)
对照组		30	0 (0.0)
	男性	18	0 (0.0)
	女性	12	0 (0.0)

表2 两组受试者血清同型半胱氨酸异常检出率比较[n(%)]

Table 2 Comparison of abnormal rates of serum levels of homocysteine between two groups[n(%)]

组别		n	异常检出率	χ²	P
研究组		30	25(83.3)^a	52.5	<0.005
	男性	17	16(94.1)
	女性	13	12(92.3)
对照组		30	0 (0.0)
	男性	18	0 (0.0)
	女性	12	0 (0.0)

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