重组人生长激素对身材矮小的小于胎龄儿身高的促增长作用

doi:10.3877/cma.j.issn.1673-5250.2012.05.007

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (05) : 585 -587. doi: 10.3877/cma.j.issn.1673-5250.2012.05.007

所属专题：文献；

论著

重组人生长激素对身材矮小的小于胎龄儿身高的促增长作用

陈丽娜¹^,^*^,^*(

), 向承发²

^1. 610072　成都，四川省医学科学院·四川省人民医院儿科
^2. 四川大学华西第二医院儿科

收稿日期:2012-06-20 修回日期:2012-08-18 出版日期:2012-10-01
通信作者: 陈丽娜

Effects of Recombinant Human Growth Hormone on Stature in Short Children Born Small for Gestational Age

Li-na CHEN¹(), Chen-fa XIANG²

^1. Department of Pediatrics, Sichuan Academy of Medical Science and Provincial People's Hospital, Chengdu 610072, Sichuan Province, China

Received:2012-06-20 Revised:2012-08-18 Published:2012-10-01
Corresponding author: Li-na CHEN
About author:
(Corresponding author: CHEN Li-na, Email: linachen9755@163.com)

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目的

探讨重组人生长激素(rhGH)治疗对身材矮小的小于胎龄(SGA)儿身高增长的疗效。

方法

选择2008年1月至2011年10月因身材矮小于四川省人民医院儿科和四川大学华西第二医院儿科门诊就诊，并接受rhGH治疗的20例身材矮小的SGA儿为研究对象。其平均年龄为(8.95±4.06)岁，rhGH治疗剂量为(0.15～0.20)U/(kg·d)，睡前皮下注射，疗程为2.3～18.0个月。对患儿治疗前、后身高(Ht)，身高标准差积分(HtSDS)及生长速率(HV)进行统计学分析(本研究遵循的程序符合四川省医学科学院与四川大学华西第二医院人体试验委员会所制定的伦理学标准，得到该委员会批准，并与受试对象监护人签署临床研究知情同意书)。

结果

20例身材矮小的SGA儿rhGH治疗前、后的Ht，HtSDS及治疗前1年与治疗后1年的HV分别为(110.34±22.1)cm与(115.88±22.29)cm，－4.31±1.47与－3.71±1.36，(4.06±0.61)cm/年与(9.86±4.01)cm/年，且差异均有统计学意义(P<0.05)。

结论

rhGH治疗对身材矮小的SGA儿Ht增长具有明显疗效。

关键词: 小于胎龄, 重组人生长激素, 身高, 儿童

Objective

To explore the therapeutic effects of recombinant human growth hormone (rhGH)on children with short stature born small for gestational age (SGA).

Methods

This was a prospective observational study with institutional ethics approval and written maternal consent. A total of 20 children with short stature born in SGA were selected in Department of Pediatrics, Sichuan Provincial People's Hospital and West China Second Hospital, Sichuan University from January 2008 to October 2011. Their average age was (8.95±4.06) years old. Each child was treated with rhGH by subcutaneous injection every night before sleep, and the dosage was (0.15-0.20) U/(kg·d) for 2.3-18.0 months. The height (Ht), height standard deviation score (HtSDS)and height velocity (HV) were statistically analyzed before and after rhGH treatment.

Results

Before and after rhGH treatment, there had significant differences in the Ht[(110.34±22.1) cm vs.(115.88±22.29) cm], HtSDS (-4.31±1.47 vs. -3.71±1.36)and HV[(4.06±0.6) cm/year vs. (9.86±4.01)cm/year](P<0.05).

Conclusions

rhGH can play a significant role in promoting growth of children with short stature born in SGA.

Key words: small for gestational age, recombinant human growth hormone, stature, child

表1 20例身材矮小SGA儿的rhGH治疗疗效(±s)

Table 1 Comparison of Ht, HtSDS and HV before and after rhGH treatment (±s)

时间	Ht(cm)	HtSDS	HV(cm/年)
治疗前	110.34±22.10	－4.31±1.47	4.06±0.61
治疗后	115.88±22.29	－3.71±1.36	9.86±4.01
t	－5.083	－3.972	－5.834
P	<0.01	<0.01	<0.01

表1 20例身材矮小SGA儿的rhGH治疗疗效(±s)

Table 1 Comparison of Ht, HtSDS and HV before and after rhGH treatment (±s)

时间	Ht(cm)	HtSDS	HV(cm/年)
治疗前	110.34±22.10	－4.31±1.47	4.06±0.61
治疗后	115.88±22.29	－3.71±1.36	9.86±4.01
t	－5.083	－3.972	－5.834
P	<0.01	<0.01	<0.01

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