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中华妇幼临床医学杂志(电子版)

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (02) : 206 -208. doi: 10.3877/cma.j.issn.1673-5250.2012.02.025

所属专题： 文献；

论著

剖宫产术中益母草注射液联合缩宫素预防产后出血的临床观察
周玉英1,*,*(), 何芙莲1   
  1. 1. 618300　四川广汉，广汉市妇幼保健院
  • 收稿日期:2012-01-05 修回日期:2012-03-09 出版日期:2012-04-01
  • 通信作者: 周玉英

Clinical Observation of Motherwort Injection and Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section

Yu-ying ZHOU1(), Fu-lian HE1   

  1. 1. Maternal and Child Health Hospital of Guanghan City, Guanghan 618300, Sichuan Province, China
  • Received:2012-01-05 Revised:2012-03-09 Published:2012-04-01
  • Corresponding author: Yu-ying ZHOU
  • About author:
    Corresponding author: ZHOU Yu-ying, Email:
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引用本文：

周玉英, 何芙莲. 剖宫产术中益母草注射液联合缩宫素预防产后出血的临床观察[J]. 中华妇幼临床医学杂志(电子版), 2012, 08(02): 206-208.

Yu-ying ZHOU, Fu-lian HE. Clinical Observation of Motherwort Injection and Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(02): 206-208.

目的

观察剖宫产术中联合应用益母草注射液与缩宫素对产后出血(PPH)的预防作用。

方法

选取2009年1月至12月于广汉市妇幼保健院进行剖宫产治疗的260例产妇为研究对象，并按照手术顺序随机分为实验组(n＝130)和对照组(n＝130)。实验组治疗方法为：剖宫产术中，胎儿娩出、血管钳钳夹脐带后，立即给予益母草注射液4 mL＋静脉滴注缩宫素20 IU，术后2 h给予益母草注射液肌内注射2 mL后，每间隔12 h肌内注射一次，2 mL/次，持续(3～5)d。对照组仅常规给予静脉滴注缩宫素20 IU(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。

结果

①剖宫产术中益母草注射液注射5 min后，实验组显效率、有效率和无效率分别为95.00%, 5.00%和0，而对照组分别为88.00%，5.00%和7.00%，两组显效率比较，差异有统计学意义(P<0.05)。②剖宫产后24 h出血情况观察，在实验组中，PPH量较少，显效率、有效率及总有效率分别为90.00%，10.00%和100.00%，对照组分别为83.00%，15.00%和98.00%，两组有效率比较，差异无统计学意义(P>0.05)。③实验组分娩前、后48 h平均红细胞压积(HCT)及其差值分别为34.29，31.2和3.09；对照组分别为34.34，31.16和2.98,两组比较，差异无统计学意义(P>0.05)。

结论

本研究结果表明剖宫产术中联合应用益母草注射液＋缩宫素作为预防子宫收缩乏力性出血的效果显著，可有效地防治PPH发生，无需补充治疗性宫缩剂或采取其他有损伤性治疗措施。

关键词: 益母草注射液, 缩宫素, 产后出血
Objective

Observe clinical effects of Motherwort injection and oxytocin in preventing postpartum hemorrhage(PPH) during cesarean section.

Methods

From January to December 2009, 260 women who delivered by cesarean section in Maternal and Child Health Hospital of Guanghan were include in the study.They were divided randomly into experimental group(n=130)and control group(n=130). Immediately after fetal delivery, experimental group was given Motherwort injection 4 mL+ oxytocin 20 IU, and when postoperative 2 h given Motherwort injection 2 mL every 12 h(3-5d). Meanwhile, control group was given oxytocin 20 IU only. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Maternal and Child Health Hospital of Guanghan City.Informed consent was obtained from each patient.

Results

①After Motherwort was given during cesarean section, the obvious effective rate, the effective rate and inefficiency rate were 95.00%, 5.00% and 0, respectively in experimental group, while those of the control group were 88.00%, 5.00% and 7.00%, respectively.There was significant difference in the obvious effective rate between two groups(P<0.05). ②There was no significant difference in effective rate of hemorrhage after postoperative 24 h between two groups.③There had no significant difference in hematocrits(HCT) value between two groups before and after surgery.

Conclusions

The application of Motherwort injection combined with oxytocin has obvious effect in preventing postpartum hemorrhage in cesarean section.

Key words: Motherwort injection, oxytocin, postpartum hemorrhage
表1 两组术中、术后出血情况比较
Table 1 Comparison of hemorrhage during and after caesarean section between two groups
组别 n 术中出血量(mL) 产后24 h出血量(mL) 术后24 h出血率[n(%)]
实验组 130 282.0±55.4 408.0±60.4 13(10.0)
对照组 130 278.0±53.5 448.0±63.1 22(16.9)
表2 两组分娩前、后48 h红细胞压积结果比较
Table 2 Comparison of hematocrits results before and after 48 h of surgery between two groups
组别 n 分娩前48 h 分娩后48 h 差值
实验组 130 34.29 31.20 3.09
对照组 130 34.34 31.16 2.98
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Xu AQ, Zen XY, Wu DR, et al. Observation of Motherwort injection on the treatment of hemorrhage[J]．Chin J Obstet Gynecol Pediatr, 2007.3(2):88-90.
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