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中华妇幼临床医学杂志(电子版) ›› 2007, Vol. 03 ›› Issue (06) : 308 -308. doi: 10.3877/cma.j.issn.1673-5250.2007.06.103

论著

宫颈鳞癌组织埃兹蛋白表达与局部浸润转移及预后的关系
江忠清, 连成瑛, 林岷, 郑秀, 张声   
  1. 福建医科大学附属第一医院妇产科(福州350005)
    福建医科大学基础医学院生理学与病理生理学系
    福建医科大学附属第一医院病理科(福州350005)
  • 出版日期:2007-12-01
  • 基金资助:
    福建省教育厅基金资助项目(JA03104,JA04210)

Relationship between expression of Ezrin protein and regional invasion, metastasis and prognosis in cervical squamous cell carcinoma

Zhong-qing JIANG, Chen-ying LIAN, Min LIN, Xiu ZHENG, Sheng ZHANG   

  1. Department of Obstetrics & Gynecology, Affiliated First Hospital, Fujian Medical University, Fuzhou 350005, China
  • Published:2007-12-01
引用本文:

江忠清, 连成瑛, 林岷, 郑秀, 张声. 宫颈鳞癌组织埃兹蛋白表达与局部浸润转移及预后的关系[J/OL]. 中华妇幼临床医学杂志(电子版), 2007, 03(06): 308-308.

Zhong-qing JIANG, Chen-ying LIAN, Min LIN, Xiu ZHENG, Sheng ZHANG. Relationship between expression of Ezrin protein and regional invasion, metastasis and prognosis in cervical squamous cell carcinoma[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2007, 03(06): 308-308.

目的

探讨宫颈鳞癌(squamous cervical carcinoma, SCC)组织埃兹蛋白(Ezrin protein)表达与浸润转移和预后的关系。

方法

采用免疫组织化学SP法检测28例正常宫颈上皮(normal cervical epithelium, NCE)、36例宫颈上皮内瘤变(cervical intraepithelial neoplasia, CIN)和68例SCC中,Ezrin蛋白的表达,并检测Ki-67增殖指数(proliferation index,PI)和CD34微血管密度(micro-vascular density, MVD)。

结果

从NCE到CIN再到SCC,Ezrin蛋白的表达水平显著升高(P<0.05)。Ezrin蛋白在SCC中表达与国际妇产科联盟(FIGO)分期、盆腔淋巴结转移、间质及脉管浸润有关(P<0.05),而与患者年龄及组织学分级无关(P>0.05)。FIGO分期为Ⅱ期、有盆腔淋巴结转移、突破深肌层间质和脉管浸润的SCC患者,Ezrin蛋白表达水平显著高于FIGO分期为Ⅰ期、无盆腔淋巴结转移、浸润深度在浅肌层间质以内和无脉管浸润的患者(P<0.05)。从NCE到CIN再到SCC,PIMVD显著升高(P<0.05)。Ezrin蛋白在SCC中表达,PIMVD比较,差异无显著意义(P>0.05)。SCC组织Ezrin蛋白高表达组患者的生存率明显低于低表达组,但差异无显著意义(P=0.0631)。

结论

Ezrin蛋白可能在SCC浸润转移过程中起重要作用,并可能成为一个有价值的预后标志物。

Objective

To examine relationship between expression of Ezrin and invasion, metastasis and prognosis in cervical squamous cell carcinoma.

Methods

The expression of Ezrin, proliferation index (PI) of cancer cells labeled by Ki-67 and micro-vascular density (MVD) labeled by CD34 in 28 cases of normal cervical epithelium(NCE), 36 cases of cervical intraepithelial neoplasm(CIN) and 68 cases of squamous carcinoma of cervix(SCC) were detected by immunohistochemistry SP method.

Results

The positive expression of Ezrin protein increased remarkably from NCE to CIN and then to SCC accordingly (P<0.05). In SCC, the expression of Ezrin correlated with FIGO staging, pelvic lymph node metastasis, stroma involvement and intravascular infiltration (P<0.05), but not correlated with patients′ age and histological grading (P>0.05). In cases with FIGO staging Ⅱ, pelvic lymph node metastasis, deeper stroma involvement and intravascular infiltration, the expression of Ezrin was significantly higher than that in those without the conditions mentioned above (P<0.05). The PI and MVD all increased remarkably from NCE to CIN and then to SCC accordingly (P<0.05). The expression of Ezrin protein in SCC was not correlated with PI and MVD, respectively (P>0.05). The patients with higher expression of Ezrin protein in SCC had lower survival rate than that in those without the conditions mentioned above, but the difference was not significant (P=0.0631).

Conclusions

Ezrin protein may play an important role during the cancer invasion and metastasis, and may be a valuable marker in prognosis in cervical squamous cell carcinoma.

图1 Ezrin protein、ki-67和CD34在宫颈鳞癌中的表达
图2 Ezrin高表达组和低表达组宫颈鳞癌患者Kaplan-Meier生存曲线
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