Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2026, Vol. 22 ›› Issue (04): 290 -297. doi: 10.3877/cma.j.issn.1673-5250.2026.04.003

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Current research status on angiogenesis inhibitors in treatment of patients with platinum-resistant recurrent ovarian cancer

Changxian Chen, Zhongfen Luo, Li Li()   

  1. Department of Gynecology, Guangxi Medical University Cancer Hospital, Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Received:2026-04-11 Revised:2026-07-08 Published:2026-08-01
  • Corresponding author: Li Li
  • Supported by:
    Scientific Research and Technology Development Program of Department of Science and Technology of Guangxi Zhuang Autonomous Region(14124004-1-24)

Platinum-resistant recurrent ovarian cancer (PRROC) is one of the most challenging clinical problems in the field of gynecologic oncology, with limited treatment options and very poor patient prognosis. In recent years, with continuous research, patients with PRROC are experiencing a historic shift from " few drugs available" to " multiple lines advancing simultaneously". Among them, the emergence of various angiogenesis inhibitors (AIs), represented by molecular targeted drugs, has brought new hope for patients with PRROC. This article focuses on the current research status of AIs in the treatment of patients with PRROC in recent years, explaining the current status and challenges of molecular targeted therapy for patients with PRROC, aiming to provide clinical reference for the treatment of PRROC patients.

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