Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2025, Vol. 21 ›› Issue (06): 628 -633. doi: 10.3877/cma.j.issn.1673-5250.2025.06.004

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Application research status of peripheral perfusion index in neonatology

Yang Gao1, Liming Zhang2,()   

  1. 1School of Clinical Medicine, Shandong Second Medical University, Weifang 261000, Shandong Province, China
    2Department of Neonatology, Weifang People′s Hospital, Weifang 261000, Shandong Province, China
  • Received:2025-01-30 Revised:2025-07-30 Published:2025-12-01
  • Corresponding author: Liming Zhang

Peripheral perfusion index (PPI) is a new generation of measurement parameter reflecting peripheral tissue perfusion. PPI can continuously and in real time reflect peripheral tissue perfusion in neonates, offering advantages such as being non-invasive, sensitive, accurate, and convenient. In recent years, the application of PPI as a tool for evaluating hemodynamic status has become increasingly widespread in neonatology. In clinical practice, PPI is primarily used for screening neonatal congenital heart disease (CHD), early diagnosis of patent ductus arteriosus (PDA) in preterm infants, early prediction of neonatal diseases, assessment of neonatal disease severity, and prediction of adverse outcomes in neonates. Additionally, PPI can be applied to guide the treatment of neonatal shock, evaluate the therapeutic efficacy of neonatal anemia, and instruct ventilator weaning for critically ill neonates. The author intends to elaborate on the latest research status regarding the concept and measurement principle of PPI, the normal reference values of PPI in neonates and its influencing factors, and clinical application of PPI in neonatology.

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