Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2025, Vol. 21 ›› Issue (04): 375 -379. doi: 10.3877/cma.j.issn.1673-5250.2025.04.001

Expert Editorial

Current research status on pathological diagnosis and malignant transformation for endometrial polyps

Danhua Shen()   

  1. Department of Pathology, Peking University People′s Hospital/Peking University International Hospital, Beijing 100044, China
  • Received:2025-01-30 Revised:2025-06-30 Published:2025-08-01
  • Corresponding author: Danhua Shen

Endometrial polyps are a relatively common lesion in gynecological clinic. There are differences between pathological and clinical diagnoses of endometrial polyps. The malignant changes are found in some endometrial polyps cases. It is necessary to pay attention to this. This article focuses on the research progress of the pathological diagnosis criteria, the types of polyps and malignant transformation in endometrial polyps, so as to provide a reference for the accurate clinical diagnosis of endometrial polyps and the prevention of their malignant transformation.

图1 1例子宫内膜息肉患者(女性,45岁)组织病理学切片图(可见腺体及间质局限性增生,腺体排列不规则,部分囊性扩张,中心可见纤维性间质及厚壁血管成分)(HE染色)注:HE为苏木精-伊红
图2 1例非典型腺肌瘤样息肉患者(女性,37岁)组织病理学切片图(可见息肉在增生腺体间出现成束排列的平滑肌成分,间质血管更为明显,部分腺体伴有非典型性)(HE染色)注:HE为苏木精-伊红
图3 1例老年性息肉患者(女性,65岁)组织病理学切片图(可见周围子宫内膜呈现绝经后萎缩表现,息肉中间质纤维化,腺体囊性扩张)(HE染色)注:HE为苏木精-伊红
图4 1例子宫内膜息肉恶变伴有浆液性上皮内癌成分患者(女性,72岁)组织病理学切片图[图4A:低倍镜下,于息肉浅层中可见排列密集的异型腺体成分(HE染色);图4B:中倍镜下,可见增生密集的腺体被衬异型细胞(HE染色);图4C:免疫组化染色显示息肉表面部分上皮及异型腺体中的上皮细胞p53强阳性表达]注:HE为苏木精-伊红
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