Current research status on tubulointerstitial injury in children with lupus nephritis

doi:10.3877/cma.j.issn.1673-5250.2023.04.001

The clinical manifestations of childhood-onset systemic lupus erythematosus (cSLE) are diverse, except for some typical manifestations of fever and rash, and the clinical manifestations are different due to different organs involved, among which the kidney is the most susceptible organ with cSLE, and also one of the main causes of death. Early identification of cSLE, assessment of disease activity, and selection of appropriate treatment regimens can effectively protect the renal function of children with this disease, and improving the prognosis of children is the key to treatment. In the past, children with lupus nephritis (LN) paid more attention to glomerular involvement, and the pathological damage of the glomerulus was used as the basis for clinical classification of LN, and more and more studies suggest that cSLE-related tubulointerstitial injury (TIN) in children, although there is no specific clinical manifestation, but it has a significant impact on the treatment of children with LN and the improvement of their prognosis. The author intends to elaborate on the clinical diagnosis and pathogenesis of LN children, the clinical significance and predictive indicators of TIN in LN children, and the latest research status of TIN in LN children, aiming to improve clinical understanding of cSLE-related TIN and further strengthen the management of children with LN.

Key words: Lupus erythematosus, systemic, Lupus nephritis, Nephritis, interstitial, Monocyte chemoattractant proteins, Lupus erythematosus, systemic-associated tubulointerstitial injury, Kidney injury molecule-1, Neutrophil gelatinase-associated lipocalin, Child

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