Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2022, Vol. 18 ›› Issue (05): 615 -620. doi: 10.3877/cma.j.issn.1673-5250.2022.05.017

Review

Research advances of reproductive tract microorganism abnormality in female infertility-related diseases

Yuting Chen, Ye Yang, Qijun Xie, Xiufeng Ling()   

  1. Reproductive Medicine Center, Women′s Hospital of Nanjing Medical University, Nanjing 210004, Jiangsu Province, China
  • Received:2022-07-22 Revised:2022-08-19 Published:2022-10-01
  • Corresponding author: Xiufeng Ling
  • Supported by:
    National Natural Science Foundation of China(81871210)

Under normal physiological conditions, there are complex and diverse types of microorganisms in the body, forming a dynamic and balanced micro-ecosystem. Female reproductive system communicates with the outside world through vaginal orifice. Colonized microorganisms in reproductive tract participate in regulating the physiological and pathological processes of homeostasis, metabolism, inflammation and immune defense in reproductive tract, whose abnormal microbiota composition (type or quantity) may closely related to female infertility-related diseases. The author intends to elaborate on the latest research progress in reproductive tract microorganism abnormalities in female infertility-related diseases, such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), chronic endometritis (CE), endometriosis (EMS) and adenomyosis, aiming to provide new ideas for the clinical mechanism, diagnosis and treatment of female infertility-related diseases.

[1]
de Vos WM, Tilg H, Van Hul M, et al. Gut microbiome and health: mechanistic insights[J]. Gut, 2022, 71(5): 1020-1032. DOI: 10.1136/gutjnl-2021-326789.
[2]
Davidson RM, Epperson LE. Microbiome sequencing methods for studying human diseases[J]. Methods Mol Biol, 2018, 1706: 77-90. DOI: 10.1007/978-1-4939-7471-9_5.
[3]
Bharti R, Grimm DG. Current challenges and best-practice protocols for microbiome analysis[J]. Brief Bioinform, 2021, 22(1): 178-193. DOI: 10.1093/bib/bbz155.
[4]
Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductive-age women[J]. Proc Natl Acad Sci U S A, 2011, 108(Suppl 1): 4680-4687. DOI: 10.1073/pnas.1002611107.
[5]
Chen X, Lu Y, Chen T, et al. The female vaginal microbiome in health and bacterial vaginosis[J]. Front Cell Infect Microbiol, 2021, 11: 631972. DOI: 10.3389/fcimb.2021.631972.
[6]
Witkin SS, Linhares IM. Why do lactobacilli dominate the human vaginal microbiota?[J]. BJOG, 2017, 124(4): 606-611. DOI: 10.1111/1471-0528.14390.
[7]
van Zyl WF, Deane SM, Dicks LMT. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria[J]. Gut Microbes, 2020, 12(1): 1831339. DOI: 10.1080/19490976.2020.1831339.
[8]
汪文博,王冠男,蔡莎莎. 抗菌肽的抗生物膜机理研究进展[J]. 生物工程学报2020, 36(7): 1277-1282. DOI: 10.13345/j.cjb.190511.
[9]
do Carmo MS, Noronha FMF, Arruda MO, et al. Lactobacillus fermentum ATCC 23271 displays in vitro inhibitory activities against Candida spp[J]. Front Microbiol, 2016, 7: 1722. DOI: 10.3389/fmicb.2016.01722.
[10]
Bruning E, Chen Y, McCue KA, et al. A 28 day clinical assessment of a lactic acid-containing antimicrobial intimate gel wash formulation on skin tolerance and impact on the vulvar microbiome[J]. Antibiotics (Basel), 2020, 9(2): 55. DOI: 10.3390/antibiotics9020055.
[11]
Yang X, Pan X, Li M, et al. Interaction between cervical microbiota and host gene regulation in caesarean section scar diverticulum[J]. Microbiol Spectr, 2022, 10(4): e0167622. DOI: 10.1128/spectrum.01676-22.
[12]
Baker JM, Chase DM, Herbst-Kralovetz MM. Uterine microbiota: residents, tourists, or invaders?[J]. Front Immunol, 2018, 9: 208. DOI: 10.3389/fimmu.2018.00208.
[13]
Kyono K, Hashimoto T, Nagai Y, et al. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study[J]. Reprod Med Biol, 2018, 17(3): 297-306. DOI: 10.1002/rmb2.12105.
[14]
Winters AD, Romero R, Gervasi MT, et al. Does the endometrial cavity have a molecular microbial signature?[J]. Sci Rep, 2019, 9(1): 9905. DOI: 10.1038/s41598-019-46173-0.
[15]
Chen C, Song X, Wei W, et al. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases[J]. Nat Commun, 2017, 8(1): 875. DOI: 10.1038/s41467-017-00901-0.
[16]
于多,乔杰. 女性上生殖道微生物群特征及其对生殖与辅助生殖的影响[J]. 中国实用妇科与产科杂志2020, 36(10): 1019-1024. DOI: 10.19538/j.fk2020100125.
[17]
Usman SF, Shuaibu IR, Durojaiye K, et al. The presence of microorganisms in follicular fluid and its effect on the outcome of in vitro fertilization-embryo transfer (IVF-ET) treatment cycles[J]. PLoS One, 2021, 16(2): e0246644. DOI: 10.1371/journal.pone.0246644.
[18]
Altmäe S. Commentary: uterine microbiota: residents, tourists, or invaders?[J]. Front Immunol, 2018, 9: 1874. DOI: 10.3389/fimmu.2018.01874.
[19]
Muhleisen AL, Herbst-Kralovetz MM. Menopause and the vaginal microbiome[J]. Maturitas, 2016, 91: 42-50. DOI: 10.1016/j.maturitas.2016.05.015.
[20]
Delgado-Diaz DJ, Jesaveluk B, Hayward JA, et al. Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression[J]. Microbiome, 2022, 10(1): 141. DOI: 10.1186/s40168-022-01337-5.
[21]
Lu C, Wang H, Yang J, et al. Changes in vaginal microbiome diversity in women with polycystic ovary syndrome[J]. Front Cell Infect Microbiol, 2021, 11: 755741. DOI: 10.3389/fcimb.2021.755741.
[22]
闫雪,石玉华,盛燕,等. 多囊卵巢综合征患者体外受精-胚胎移植后的妊娠结局[J]. 中华妇产科杂志2011, 46(12): 923-927. DOI: 10.3760/cma.j.issn.0529-567x.2011.12.010.
[23]
Tu Y, Zheng G, Ding G, et al. Comparative analysis of lower genital tract microbiome between PCOS and healthy women[J]. Front Physiol, 2020, 11: 1108. DOI: 10.3389/fphys.2020.01108.
[24]
Dewailly D, Robin G, Peigne M, et al. Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary[J]. Hum Reprod Update, 2016, 22(6): 709-724. DOI: 10.1093/humupd/dmw027.
[25]
Hong X, Qin P, Huang K, et al. Association between polycystic ovary syndrome and the vaginal microbiome: a case-control study[J]. Clin Endocrinol (Oxf), 2020, 93(1): 52-60. DOI: 10.1111/cen.14198.
[26]
Wu J, Ning Y, Tan L, et al. Characteristics of the vaginal microbiome in women with premature ovarian insufficiency[J]. J Ovarian Res, 2021, 14(1): 172. DOI: 10.1186/s13048-021-00923-9.
[27]
Lüll K, Saare M, Peters M, et al. Differences in microbial profile of endometrial fluid and tissue samples in women with in vitro fertilization failure are driven by Lactobacillus abundance[J]. Acta Obstet Gynecol Scand, 2022, 101(2): 212-220. DOI: 10.1111/aogs.14297.
[28]
Chen W, Wei K, He X, et al. Identification of uterine microbiota in infertile women receiving fertilization with and without chronic endometritis[J]. Front Cell Dev Biol, 2021, 9: 693267. DOI: 10.3389/fcell.2021.693267.
[29]
Chen P, Chen P, Guo Y, et al. Interaction between chronic endometritis caused endometrial microbiota disorder and endometrial immune environment change in recurrent implantation failure[J]. Front Immunol, 2021, 12: 748447. DOI: 10.3389/fimmu.2021.748447.
[30]
舒思楠,叶红,刘程程,等. 慢性子宫内膜炎与生殖相关疾病的研究进展[J]. 中华生殖与避孕杂志2021, 41(10): 893-897. DOI: 10.3760/cma.j.cn101441-20200416-00216.
[31]
Li B, Duan H, Wang S, et al. Gradient boosting machine learning model for defective endometrial receptivity prediction by macrophage-endometrium interaction modules[J]. Front Immunol, 2022, 13: 842607. DOI: 10.3389/fimmu.2022.842607.
[32]
王智超,朱亮. 子宫内膜异位症合并不孕患者经体外受精/卵胞质内单精子注射-胚胎移植治疗后妊娠结局及相关因素的分析[J]. 中华生殖与避孕杂志2017, 37(3): 222-226. DOI: 10.3760/cma.j.issn.2096-2916.2017.03.009.
[33]
Lin WC, Chang CYY, Hsu YA, et al. Increased risk of endometriosis in patients with lower genital tract infection: a nationwide cohort study[J]. Medicine (Baltimore), 2016, 95(10): e2773. DOI: 10.1097/MD.0000000000002773.
[34]
Akiyama K, Nishioka K, Khan KN, et al. Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis[J]. Am J Reprod Immunol, 2019, 82(2): e13147. DOI: 10.1111/aji.13147.
[35]
Wei W, Zhang X, Tang H, et al. Microbiota composition and distribution along the female reproductive tract of women with endometriosis[J]. Ann Clin Microbiol Antimicrob, 2020, 19(1): 15. DOI: 10.1186/s12941-020-00356-0.
[36]
Ata B, Yildiz S, Turkgeldi E, et al. The endobiota study: comparison of vaginal, cervical and gut microbiota between women with stage 3/4 endometriosis and healthy controls[J]. Sci Rep, 2019, 9(1): 2204. DOI: 10.1038/s41598-019-39700-6.
[37]
Ruffier d′Epenoux L, Tessier E, Guillouzouic A, et al. Assessment of the performance of the aptima bacterial vaginosis assay over a 3-month period in a French hospital[J]. Microbiol Spectr, 2022: e0130122(2022-08-18)[2022-08-19]. DOI: 10.1128/spectrum.01301-22 (published online ahead of print).

URL    
[38]
Walther-António MR, Chen J, Multinu F, et al. Potential contribution of the uterine microbiome in the development of endometrial cancer[J]. Genome Med, 2016, 8(1): 122. DOI: 10.1186/s13073-016-0368-y.
[39]
李林双,章汉旺. 子宫内膜异位症患者的不孕机制和助孕策略研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2020, 16(3): 272-277. DOI: 10.3877/cma.j.issn.1673-5250.2020.03.004.
[40]
Horton J, Sterrenburg M, Lane S, et al. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and Meta-analysis[J]. Hum Reprod Update, 2019, 25(5): 592-632. DOI: 10.1093/humupd/dmz012.
[41]
Kunaseth J, Waiyaput W, Chanchaem P, et al. Vaginal microbiome of women with adenomyosis: a case-control study[J]. PLoS One, 2022, 17(2): e0263283. DOI: 10.1371/journal.pone.0263283.
[42]
Dittmer KE, Pradhan P, Tompkins QC, et al. Cloning and characterization of glycogen branching and debranching enzymes from the parasitic protist Trichomonas vaginalis[J]. Biochimie, 2021, 186: 59-72. DOI: 10.1016/j.biochi.2021.04.007.
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