Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2021, Vol. 17 ›› Issue (06): 643 -649. doi: 10.3877/cma.j.issn.1673-5250.2021.06.004

Forum

Advance of potential biomarkers in neonatal sepsis

Yang Cao, Hanmin Liu()   

  • Received:2021-07-29 Revised:2021-11-07 Published:2021-12-01
  • Corresponding author: Hanmin Liu
  • Supported by:
    Key R&D Project of Sichuan Provincial Department of Science and Technology(2019YFS0037)

Neonatal sepsis (NS), remains a major cause of mortality among neonates worldwide, accounting for approximately 16% neonatal mortality. NS is divided into early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS). Nevertheless, the clinical therapy of NS is usually delayed due to lack of biomarkers with high specificity. Thus, it is crucial to investigate ideal biomarkers for earlier diagnosis and treatment of NS, and avoiding complications of neonates. Biomarkers have been widely used including C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA). We are aiming to summarize classifications and clinical characteristics, diagnosis and therapy, and advances of potential biomarkers in NS.

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