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Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2021, Vol. 17 ›› Issue (05): 497 -502. doi: 10.3877/cma.j.issn.1673-5250.2021.05.001

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Protection effects of vitamin D and its analogues on children with pediatric kidney diseases

Hui Shang, Yuhong Tao†()   

  • Received:2021-05-01 Revised:2021-09-11 Published:2021-10-01
  • Corresponding author: Yuhong Tao
  • Supported by:
    Applied Basic Research Project of Science & Technology Department of Sichuan Province(2017JY0076)
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Vitamin D is a fat-soluble vitamin, which plays a role through its active forms acting on vitamin D receptor (VDR). In addition to the role of regulating calcium and phosphorus metabolism, vitamin D also has various nonclassical effects, such as immunoregulation, inhibiting inflammation, regulating cell growth and differentiation, promoting bone growth, anti-tumor cell proliferation and so on. Vitamin D deficiency is common in children with kidney disease. This paper intends to focus on the classification of vitamin D and its analogues, and their mechanisms of protecting pediatric kidney diseases, including inhibiting activity of renin-angiotensin-aldosterone system (RAAS), protecting podocytes, reducing proteinuria, relieving renal inflammation, delaying renal fibrosis, preventing cardiovascular diseases, and so on.

Key words: Vitamin D, Vitamin D analogues, Kidney diseases, Glomerulonephritis, Nephrotic syndrome, Lupus nephritis, Chronic kidney disease, Renal protection, Child
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