Chinese Medical E-ournals Database
Adv Search
中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2021, Vol. 17 ›› Issue (05): 497 -502. doi: 10.3877/cma.j.issn.1673-5250.2021.05.001

Forum

Protection effects of vitamin D and its analogues on children with pediatric kidney diseases

Hui Shang, Yuhong Tao†()   

  • Received:2021-05-01 Revised:2021-09-11 Published:2021-10-01
  • Corresponding author: Yuhong Tao
  • Supported by:
    Applied Basic Research Project of Science & Technology Department of Sichuan Province(2017JY0076)
HTML ( ) PDF ( )

Vitamin D is a fat-soluble vitamin, which plays a role through its active forms acting on vitamin D receptor (VDR). In addition to the role of regulating calcium and phosphorus metabolism, vitamin D also has various nonclassical effects, such as immunoregulation, inhibiting inflammation, regulating cell growth and differentiation, promoting bone growth, anti-tumor cell proliferation and so on. Vitamin D deficiency is common in children with kidney disease. This paper intends to focus on the classification of vitamin D and its analogues, and their mechanisms of protecting pediatric kidney diseases, including inhibiting activity of renin-angiotensin-aldosterone system (RAAS), protecting podocytes, reducing proteinuria, relieving renal inflammation, delaying renal fibrosis, preventing cardiovascular diseases, and so on.

Key words: Vitamin D, Vitamin D analogues, Kidney diseases, Glomerulonephritis, Nephrotic syndrome, Lupus nephritis, Chronic kidney disease, Renal protection, Child
[5]
Lee SM, An WS. Supplementary nutrients for prevention of vascular calcification in patients with chronic kidney disease[J]. Korean J Intern Med, 2019, 34(3): 459-469. DOI: 10.3904/kjim.2019.125.
[6]
Hampson KJ, Gay ML, Band ME. Pediatric nephrotic syndrome: pharmacologic and nutrition management[J]. Nutr Clin Pract, 2021, 36(2): 331-343. DOI: 10.1002/ncp.10622.
[7]
Polderman N, Cushing M, McFadyen K, et al. Dietary intakes of children with nephrotic syndrome[J]. Pediatr Nephrol, 2021, 36(9): 2819-2826. DOI: 10.1007/s00467-021-05055-2.
[8]
Banerjee S, Basu S, Akhtar S, et al. Free vitamin D levels in steroid-sensitive nephrotic syndrome and healthy controls[J]. Pediatr Nephrol, 2020, 35(3): 447-454. DOI: 10.1007/s00467-019-04433-1.
[9]
Yang SP, Ong L, Loh TP, et al. Calcium, vitamin D, and bone derangement in nephrotic syndrome[J]. J Asean Fed Endocr Soc, 2021, 36(1): 50-55. DOI: 10.15605/jafes.036.01.12.
[10]
Szymczak-Pajor I, S＇liwińska A. Analysis of association between vitamin D deficiency and insulin resistance[J]. Nutrients, 2019, 11(4): 794. DOI: 10.3390/nu11040794.
[11]
Lipińska-Opaka A, Tomaszewska A, Kubiak JZ, et al. Vitamin D and immunological patterns of allergic diseases in children[J]. Nutrients, 2021, 13(1): 177. DOI: 10.3390/nu13010177.
[12]
Yang S, Li A, Wang J, et al. Vitamin D receptor: a novel therapeutic target for kidney diseases[J]. Curr Med Chem, 2018, 25(27): 3256-3271. DOI: 10.2174/0929867325666180214122352.
[13]
Subandiyah K, Khanifa H, Kardani AK. Effect of corticosteroid and vitamin D3 as combined therapy on 25(OH) vitamin D serum level and regulatory T (Treg) cells population in children with idiopathic nephrotic syndrome[J]. Bali Med J, 2018, 7(3): 639-644. DOI: 10.15562/bmj.v7i3.769.
[14]
Song Z, Xiao C, Jia X, et al. Vitamin D/VDR protects against diabetic kidney disease by restoring podocytes autophagy[J]. Diabetes Metab Syndr Obes, 2021, 14: 1681-1693. DOI: 10.2147/Dmso.S303018.
[15]
Shi W, Guo L, Liu G, et al. Protective effect of calcitriol on podocytes in spontaneously hypertensive rat[J]. J Chin Med Assoc, 2018, 81(8): 691-698. DOI: 10.1016/j.jcma.2018.01.010.
[16]
Campbell KN, Tumlin JA. Protecting podocytes: a key target for therapy of focal segmental glomerulosclerosis[J]. Am J Nephrol, 2018, 47(Suppl 1): 14-29. DOI: 10.1159/000481634.
[17]
Zeier M, Reiser J. suPAR and chronic kidney disease-a podocyte story[J]. Pflugers Arch, 2017, 469(7-8): 1017-1020. DOI: 10.1007/s00424-017-2026-7.
[18]
Li Z, Wu N, Wang J, et al. Roles of endovascular calyx related enzymes in endothelial dysfunction and diabetic vascular complications[J]. Front Pharmacol, 2020, 11: 590614. DOI: 10.3389/fphar.2020.590614.
[19]
Masola V, Zaza G, Onisto M, et al. Heparanase: another renal player controlled by vitamin D[J]. J Pathol, 2016, 238(1): 7-9. DOI: 10.1002/path.4639.
[20]
Li XH, Huang XP, Pan L, et al. Vitamin D deficiency may predict a poorer outcome of IgA nephropathy[J]. BMC Nephrol, 2016, 17: 164. DOI: 10.1186/s12882-016-0378-4.
[21]
Deng J, Zheng X, Xie H, et al. Calcitriol in the treatment of IgA nephropathy with non-nephrotic range proteinuria: a Meta-analysis of randomized controlled trials[J]. Clin Nephrol, 2017, 87(1): 21-27. DOI: 10.5414/CN108915.
[22]
Yuan D, Fang Z, Sun F, et al. Effect of vitamin D and tacrolimus combination therapy on IgA nephropathy[J]. Med Sci Monit, 2017, 23: 3170-3177. DOI: 10.12659/msm.905073.
[23]
Zhao D, Zhang CJ, Yang R, et al. Effect of 1，25(OH)2D3 on the proliferation of human mesangial cells and their expression of Ki67[J]. Genet Mol Res, 2017, 16(2): gmr16029191. DOI: 10.4238/gmr16029191.
[24]
Xiaowei L, Bo W, Li L, et al. Comparison of the effects of valsartan plus activated vitamin D versus valsartan alone in IgA nephropathy with moderate proteinuria[J]. Int Urol Nephrol, 2020, 52(1): 129-136. DOI: 10.1007/s11255-019-02329-5.
[25]
Tamayo M, Manzanares E, Bas M, et al. Calcitriol (1，25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase a signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes[J]. Heart Rhythm, 2017, 14(3): 432-439. DOI: 10.1016/j.hrthm.2016.12.013.
[26]
Lin TC, Wu JY, Kuo ML, et al. Correlation between disease activity of pediatric-onset systemic lupus erythematosus and level of vitamin D in Taiwan: a case-cohort study[J]. J Microbiol Immunol Infect, 2018, 51(1): 110-114. DOI: 10.1016/j.jmii.2015.12.005.
[27]
Correa-Rodríguez M, Pocovi-Gerardino G, Callejas-Rubio JL, et al. Vitamin D levels are associated with disease activity and damage accrual in systemic lupus erythematosus patients[J]. Biol Res Nurs, 2021, 23(3): 455-463. DOI: 10.1177/1099800420983596.
[28]
Pérez-Ferro M, Romero-Bueno FI, Serrano Del Castillo C, et al. A subgroup of lupus patients with nephritis, innate T cell activation and low vitamin D is identified by the enhancement of circulating MHC class Ⅰ-related chain A[J]. Clin Exp Immunol, 2019, 196(3): 336-344. DOI: 10.1111/cei.13273.
[29]
Brunner HI, Bennett MR, Gulati G, et al. Urine biomarkers to predict response to lupus nephritis therapy in children and young adults[J]. J Rheumatol, 2017, 44(8): 1239-1248. DOI: 10.3899/jrheum.161128.
[30]
Yu Q, Qiao Y, Liu D, et al. Vitamin D protects podocytes from autoantibodies induced injury in lupus nephritis by reducing aberrant autophagy[J]. Arthritis Res Ther, 2019, 21(1): 19. DOI: 10.1186/s13075-018-1803-9.
[31]
Go DJ, Lee JY, Kang MJ, et al. Urinary vitamin D-binding protein, a novel biomarker for lupus nephritis, predicts the development of proteinuric flare[J]. Lupus, 2018, 27(10): 1600-1615. DOI: 10.1177/0961203318778774.
[32]
Kumar YA, Vivek K, Vinod K, et al. The effect of vitamin D supplementation on bone metabolic markers in chronic kidney disease[J]. J Bone Miner Res, 2018, 33(3): 404-409. DOI: 10.1002/jbmr.3314.
[33]
Lerch C, Shroff R, Wan M, et al. Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease[J]. Nephrol Dial Transplant, 2018, 33(12): 2208-2217. DOI: 10.1093/ndt/gfy012.
[34]
Gluba-Brzózka A, Franczyk B, Ciakowska-Rysz A, et al. Impact of vitamin D on the cardiovascular system in advanced chronic kidney disease (CKD) and dialysis patients[J]. Nutrients, 2018, 10(6):709. DOI: 10.3390/nu10060709.
[35]
Dahan I, Thawho N, Farber E, et al. The iron-Klotho-VDR axis is a major determinant of proximal convoluted tubule injury in haptoglobin 2-2 genotype diabetic nephropathy patients and mice[J]. J Diabetes Res, 2018, 2018: 7163652. DOI: 10.1155/2018/7163652.
[36]
Imani PD, Aujo J, Kiguli S, et al. Chronic kidney disease impacts health-related quality of life of children in Uganda, East Africa[J]. Pediatr Nephrol, 2021, 36(2): 323-331. DOI: 10.1007/s00467-020-04705-1.
[1]
Gembillo G, Cernaro V, Salvo A, et al. Role of vitamin D status in diabetic patients with renal disease[J]. Medicinca (Kaunas), 2019, 55(6): 273. DOI: 10.3390/medicina55060273.
[2]
Melamed ML, Chonchol M, Gutiérrez OM, et al. The role of vitamin D in CKD stages 3 to 4: report of a scientific workshop sponsored by the national kidney foundation[J]. Am J Kidney Dis, 2018, 72(6): 834-845. DOI: 10.1053/j.ajkd.2018.06.031.
[3]
Baur AC, Brandsch C, Steinmetz B, et al. Differential effects of vitamin D3 vs vitamin D2 on cellular uptake, tissue distribution and activation of vitamin D in mice and cells[J]. J Steroid Biochem Mol Biol, 2020, 204: 105768. DOI: 10.1016/j.jsbmb.2020.105768.
[4]
Zhang T, Ju H, Chen H, et al. Comparison of paricalcitol and calcitriol in dialysis patients with secondary hyperparathyroidism: a Meta-analysis of randomized controlled studies[J]. Ther Apher Dial, 2019, 23(1): 73-79. DOI: 10.1111/1744-9987.12760.
[37]
Shroff R, Aitkenhead H, Costa N, et al. Normal 25-hydroxyvitamin D levels are associated with less proteinuria and attenuate renal failure progression in children with CKD[J]. J Am Soc Nephrol, 2016, 27(1): 314-322. DOI: 10.1681/ASN.2014090947.
[38]
Paydas S, Karaer R, Kara E. Pleiotrophic effects of vitamin D in proteinuric chronic kidney disease patients[J]. Turk Neph Dial Transpl, 2018, 27(1): 76-81. DOI: 10.5262/tndt.2018.1001.06.
[39]
Govender D, Damjanovic L, Gaza CA, et al. Vitamin D decreases silencer methylation to downregulate renin gene expression[J]. Gene, 2021, 786: 145623. DOI: 10.1016/j.gene.2021.145623.
[40]
Zhang YL, Qiao SK, Guo XN, et al. Arsenic trioxide-induced cell apoptosis and cell cycle arrest are potentiated by 1，25-dihydroxyvitamin D3 in human leukemia K562 cells[J]. Oncol Lett, 2021, 22(1): 509. DOI: 10.3892/ol.2021.12770.
[41]
Sergeev IN. Vitamin D status and vitamin D-dependent apoptosis in obesity[J]. Nutrients, 2020, 12(5): 1392. DOI: 10.3390/nu12051392.
[42]
Wu CC, Liao MT, Hsiao PJ, et al. Antiproteinuria effect of calcitriol in patients with chronic kidney disease and vitamin D deficiency: a randomized controlled study[J]. J Ren Nutr, 2020, 30(3): 200-207. DOI: 10.1053/j.jrn.2019.09.001.
[43]
Ahmed OM, Ali TM, Abdel Gaid MA, et al. Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α，p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats[J]. PLoS One, 2019, 14(9): e0214349. DOI: 10.1371/journal.pone.0214349.
[44]
Hamzawy M, Gouda S, Rashid L, et al. The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy[J]. Endocrine, 2017, 58(1): 66-80. DOI: 10.1007/s12020-017-1402-6.
[45]
Galior K, Grebe S, Singh R. Development of vitamin D toxicity from overcorrection of vitamin D deficiency: a review of case reports[J]. Nutrients, 2018, 10(8): 953. DOI: 10.3390/nu10080953.
[46]
Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, et al. Vitamin D toxicity-a clinical perspective[J]. Front Endocrinol (Lausanne), 2018, 9: 550. DOI: 10.3389/fendo.2018.00550.
[47]
Abdullah A, Hussain S, Rita A, et al. Vitamin D intoxication and nephrocalcinosis in a young breastfed infant[J]. Case Rep Endocrinol, 2021, 2021: 3286274. DOI: 10.1155/2021/3286274.
[1] Hongyu Tao, Jingjing Ye, Jin Yu, Xiuzhen Yang, Jingjing Qian, Bin Xu, Weize Xu, Qiang Shu. Value of contrast transthoracic echocardiography in assessing right-to-left shunt-related diseases in children[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(10): 959-965.
[2] Qilong Zhang, Yi Liu, Huili Lu, Hui Luo, Chenglin Li, Jing Wang, Hui Wang. A single-center retrospective analysis of efficacy and safety of obinutuzumab for treating phospholipase A2 receptor associated membranous nephropathy[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2024, 17(05): 379-384.
[3] Xiaofei Li, Hongli Liu, Qiuling Shi, Jing Tian, Li Li, Hongbo Qi, Xin Luo. A prospective randomized controlled study of low intensity focused ultrasound uterine involution treatment for prevention and treatment of postpartum hemorrhage in natural childbirth women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 534-539.
[4] Qin Liu, Hanmin Liu, Liang Xie. Current status of research on the role of matrix metalloproteinases in the pathogenesis of childhood asthma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 564-568.
[5] Yun Xiang, You Lu, Fan Yang. Current research status of correlation between per-and polyfluoroalkyl substances exposure and childhood obesity[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 569-574.
[6] Xiaoli Yang, Wanfu Li, Zhu Ma, Lan Ma, Yi Zheng, Xiaoli Fu, Jing Wang. Application effect of one-step forceps needle method in laparoscopic high ligation of hernia sac in children[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 535-538.
[7] Chinese Society of Organ Transplantation of Chinese Medical Association, Surgery Group of Chinese Society of Surgery of Chinese Medical Association, Transplantation Group of Chinese Society of Surgery of Chinese Medical Association, South China Alliance of Split Liver Transplantation. Chinese Clinical Practice Guidelines on Split Liver Transplantation in Children[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 593-601.
[8] Jun Liu, Wenjing Qiu, Fanghao Sun, Songying Li, Shuhong Yi, Binsheng Fu, Yang Yang, Hui Luo. Comparison of in vivo and in vitro split liver transplantation in pediatric liver transplantation[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 688-693.
[9] Bokai Cheng, Guang Yang. Progress of research on application of hyperinsulinemic-euglycemic clamp technique for assessing insulin resistance in patients with chronic kidney disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(06): 334-339.
[10] Sihan Liu, Jing Zhang. Relationship of 25-hydroxyvitamin D3 and the ratio of serum iron to C-reactive protein with renal function impairment in the elderly[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(05): 268-272.
[11] Rongrong Feng, Xiaole Su, Lihua Wang. Research progress on biological markers related to complication of cardiovascular disease in patients with chronic kidney disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(05): 273-278.
[12] Junnan Guo, Hui Lin, Yilin Ren, Xi Qiao. Progress of research on the role of amino acid metabolism disturbance in the transition from AKI to CKD[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(05): 283-287.
[13] Guibin Fang, Jin Xiao, Guangtao Fu, Qiujian Zheng. Factors affecting walking ability in elderly patients with hip fractures one year after surgery[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2024, 10(05): 273-280.
[14] Junling Han, Gang Wang, Liying Ma, Ying Lian, Hui Xu. Study on the therapeutic effect of vitamin D combined with povidone bromide tablets on diarrhea type patients with irritable bowel syndrome and its impact on intestinal barrier function indicators[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(06): 560-564.
[15] Chen Zhang, Ming Qin, Juan Dong, Yulong Chen. Diagnostic value of ultrasound in ischemic changes of intestinal volvulus in children[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(06): 565-568.
Viewed
Full text


Abstract

Copyright © Chinese Medical Association, Chinese Medical Multimedia Press  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号