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Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2020, Vol. 16 ›› Issue (06): 739 -744. doi: 10.3877/cma.j.issn.1673-5250.2020.06.018

Special Issue: ；

Review

Research progresses of pathogenesis of neonatal necrotizing enterocolitis

Na Ma1, Mohd Jaish Siddiqui1, Bin Xia1,†()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-07-18 Revised:2020-11-06 Published:2020-12-01
  • Corresponding author: Bin Xia
  • Supported by:
    National Natural Science Foundation of China(81370738)
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Neonatal necrotizing enterocolitis (NEC) is the frequent and lethal gastrointestinal inflammation disease in neonatal intensive care units, and seriously endangering the life of neonates. At present, the main risk factors of NEC consist of prematurity, microbiome dysbiosis, inflammatory reaction, blood products transfusion and improper feeding, etc., but the pathogenesis of NEC is not identify yet. This article reviews the latest research on the pathogenesis of NEC in recent years.

Key words: Enterocolitis, necrotizing, Infant, premature, Inflammation, Gastrointestinal microbiome, Blood transfusion, Risk factors, Etiology, Infant, newborn
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