Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (04): 432 -436. doi: 10.3877/cma.j.issn.1673-5250.2019.04.013

Special Issue:

Original Article

Clinical application of neonatal screening test of pulse oxygen saturation at county, township and village level hospitals

Jia Chen1, Jing Yu1,(), Lirong Guan1, Li Xu2, Caiyong Liu3, Meifeng Guo4   

  1. 1. Department of Pediatrics, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China
    2. Department of Pediatrics, People′s Hospital of Beichuan Qiang Autonomous County, Mianyang 622750, Sichuan Province, China
    3. Department of Pediatrics, Maternal and Child Health Hospital of Santai County, Mianyang 621100, Sichuan Province, China
    4. Department of Pediatrics, Maternal and Child Health Hospital of Youxian District, Mianyang 621000, Sichuan Province, China
  • Received:2018-11-13 Revised:2019-06-14 Published:2019-08-01
  • Corresponding author: Jing Yu
  • About author:
    Corresponding author: Yu Jing, Email:
  • Supported by:
    Scientific Research Project of Sichuan Health and Family Planning Commission(16PJ186)
Objective

To explore the effectiveness and feasibility of early detection of neonatal infection and pulmonary disease by pulse oxygen saturation (SpO2) screening at county, township and village level hospitals in western area of China with relatively short of resources.

Methods

A total of 15 720 newborns without obvious abnormal clinical manifestations from September 2015 to June 2017 who were born at 14 county and village level hospitals in Mianyang City, Sichuan Province such as People′s Hospital of Beichuan Qiang Autonomous County, Maternal and Child Health Hospital of Santai County, Maternal and Child Health Hospital of Youxian District, etc., were chosen as research subjects. At 12 h after birth, SpO2 screening was implemented. The first screening result was negative, then the second screening would be done at 48 h after birth, on the contrary, then that second screening was not done. Newborns those who had positive screening results were transfered to Department of Neonatology, in order to clarify the presence of critical congenital heart disease by echocardiography. The causes of hypoxemia in neonates without critical congenital heart disease were further analyzed by clinical manifestations and laboratory examination results. This study was in line with World Medical Association Declaration of Helsinki revised in 2013, and informed contents were obtained from guardians of all participates.

Results

① Among 15 720 neonates of this study, a total of 34 cases had a positive screening results of SpO2, positive rate of screening test of SpO2 was 0.2%. ②Among 34 cases with screening positive results of SpO2, there were critical congenital heart disease, neonatal pneumonia, neonatal sepsis, pneumothorax and wet lung of newborns of 6, 19, 5, 3 cases and 1 case, respectively. All 28 neonates with hypoxemia who were not caused by heart disease were immediately transferred to Department of Neonatology for timely and effective treatment, and all discharged from hospital after recovery.

Conclusions

In primary level hospitals, routine screening test of SpO2 to newborns within 48 h after birth, may helpful for eraly find neonate with critical congenital heart disease and other causes of hypoxemia to take timely and effective treatment measures. Operation of neonatal screening test of SpO2 is simple and its equipment cost is low. Clinical application of neonatal screening test of SpO2 shows an advantage in primary level hospitals widely.

表1 本研究15 720例受试儿一般临床资料比较[例数(%)]
表2 本研究28例非心脏因素所致低氧血症的脉搏血氧饱和度筛查结果呈阳性患儿病例资料
表3 本研究6例脉搏血氧饱和度筛查结果呈阳性的危重型先天性心脏病患儿病例资料
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