Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (05): 518 -523. doi: 10.3877/cma.j.issn.1673-5250.2017.05.004

Special Issue:

Original Article

Analysis of influencing factors of very low birth weight infants with bronchopulmonary dysplasia

Lin Zhang1, Xiaoyan Yang2, Jing Shi2,()   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;Department of Neonatology, People′s Hospital of Jianyang City, Jianyang 641400, Sichuan Province, China
    2. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2017-06-08 Revised:2017-08-25 Published:2017-10-01
  • Corresponding author: Jing Shi
  • About author:
    Corresponding author: Shi Jing, Email:
Objective

To explorer the influencing factors of very low birth weight infants (VLBWI) with bronchopulmonary dysplasia (BPD).

Methods

A total of 163 VLBWI in neonatal intensive care unit of West China Second University Hospital, Sichuan University, from January to December 2015, were chosen as study subjects. They were divided into BPD group(n=57) and non BPD group (n=106) according to discharged diagnosis. Clinical data were analyzed retrospectively, and following factors were compared statistically to explore the influences on BPD in VLBWI. ① A total of 12 items of maternal prenatal conditions between 2 groups, including age, parity, primiparity, multifetation, regular prenatal examination, complications at delivery, delivery mode, etc.. ② A total of 14 items of neonatal conditions, including gestational age, birth weight, gender, 1 min and 5 min Apgar scores, postnatal usage of pulmonary surfactant (PS), usage rate and duration of mechanical ventilation and postnatal complications.etc.. Based on the results of existing studies, clinical experience and results of univariate analysis, multivariate unconditional logistic regression analysis was performed about the 13 factors with significant differences, in order to discuss independent impact factors about BPD in VLBWI.

Results

①Results of univariate analysis showed that: the ratio of hypertension or preeclampsia during pregnancy and caesarean section of maternal in BPD group were lower than those of non BPD group, but the ratio of antepartum hemorrhage was higher than that of non BPD group, and the differences were statistically significant (P<0.05). Gestational age and birth weight of VLBWI in BPD group were younger or lighter than those of non BPD group. Ratio of Apgar score≤7 scores of 1 min and 5 min after birth, usage rate of PS, usage rate and duration of mechanical ventilation, incidence rates of neonatal respiratory distress syndrome (NRDS), patent ductus arteriosus (PDA) and periventricular-intraventricular hemorrhage/periventricular leukomalacia (PIVH/PVL) of neonates in BPD group were all higher or longer than those of non BPD group, and the differences were statistically significant (P<0.05). ②Results of multivariate unconditional logistic regression analysis showed that: gestational age<29.5 weeks(OR=3.876, 95%CI: 1.260-11.924, P<0.05), birth weight<1 300 g (OR=3.983, 95%CI: 1.165-13.621, P<0.05) were independent risk factors about suffering BPD in VLBWI; duration of mechanical ventilation<7 d (OR=0.146, 95%CI: 0.050-0.424, P<0.05) was an independent protection factor about suffering BPD in VLBWI.

Conclusion

Avoiding premature delivery and proper mechanical ventilation strategy might reduce the incidence rate of BPD in VLBWI.

表1 2组极低出生体重儿母亲产前一般临床资料比较
表2 2组极低出生体重儿一般临床资料比较
表3 极低出生体重儿发生支气管肺发育不良影响因素的多因素非条件logistic回归分析的变量含义及赋值情况
表4 极低出生体重儿发生支气管肺发育不良影响因素的多因素非条件logistic回归分析
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