Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (02): 135 -138. doi: 10.3877/cma.j.issn.1673-5250.2017.02.003

Special Issue:

Editorial

Research of CXCL12/CXCR4/CXCR7 signal pathway, pregnancy and preeclampsia pathogenesis

Tingting Wang1, Jin Yan1, Ying Zheng1, Xiang Kong1,()   

  1. 1. Department of Obstetrics and Gynecology, Medical School of Yangzhou University (Subei Hospital), Yangzhou 225001, Jiangsu Province, China
  • Received:2016-10-30 Revised:2017-02-13 Published:2017-04-01
  • Corresponding author: Xiang Kong
  • About author:
    Corresponding author: Kong Xiang, Email:

Preeclampsia (PE) is a pregnancy-specific diseases, pregnant women in the second and third trimesters will appear hypertension and proteinuria and other symptoms, even leading to them perinatal maternal and fetal death. Currently pathogenesis of PE remains unclear, the relationship between PE and inflammation, immunization become a hot clinical research topic, especially about chemokine. Chemokine ligand (CXCL)12 and chemokine receptors (CXCR)4, and CXCR7 is one of the hot topics of PE research. This article talks about how CXCL12/CXCR4/CXCR7 signal pathway regulates trophoblastic cell and placenta formation, in order to explore the pathogenesis of PE.

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