Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (01): 116 -119. doi: 10.3877/cma.j.issn.1673-5250.2017.01.022

Special Issue:

Review

Research progress on group B Streptococcal vaccines

Kankan Gao1, Huamin Zhong1, Qihua Liang1, Haiying Liu1,()   

  1. 1. Department of Clinical Laboratory, Guangzhou Women and Children′s Medical Center, Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China
  • Received:2016-07-11 Revised:2017-01-01 Published:2017-02-01
  • Corresponding author: Haiying Liu
  • About author:
    Corresponding author: Liu Haiying, Email:

Group B Streptococcal (GBS), a gram-positive Streptococcus, is one of the important pathogenic bacteria which can causes neonatal sepsis and meningitis. The main measure of GBS is intrapartum antibiotics prevention (IAP), which plays an important role in early-onset GBS disease (GBS-EOD), but remains a high infection rates in late-onset GBS disease(GBS-LOD). What′s more, with the extensive use of antimicrobial drugs, the GBS drug resistance rate increased gradually. So that GBS vaccines provide a new method to prevent neonatal GBS infection, especially the capsular polysaccharide conjugate vaccine, the phase Ⅰ and Ⅱ clinical trials have been completed, and the protective antibody levels has been researching. This research will focus on the research progress on GBS vaccines in order to provide reference for further development of GBS vaccines.

[1]
Johri AK, Paoletti LC, Glaser P, et al. Group B Streptococcus: global incidence and vaccine development[J]. Nat Rev Microbiol, 2006, 4(12): 932-942.
[2]
Heath PT, Feldman RG. Vaccination against group B Streptococcus[J]. Expert Rev Vaccines, 2005, 4(2): 207-218.
[3]
Edmond KM, Kortsalioudaki C, Scott S, et al. Group B Streptococcal disease in infants aged younger than 3 months: systematic review and Meta-analysis[J]. Lancet, 2012, 379(9815): 547-556.
[4]
朱敏,范建霞,程利南.围产期B族链球菌感染的研究进展[J].中华妇产科杂志,2005,40(2):137-141.
[5]
Liu H, Zeng H, Wang W, et al. Estimating the burden of invasive Group B Streptococcal disease in young infants in southern mainland China: an observational study[J]. Int J Clin Exp Med, 2015, 8(8): 13699-13707.
[6]
Wang P, Ma Z, Tong J, et al. Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates[J]. Int J Infect Dis, 2015, 37(2): 115-118.
[7]
Schrag SJ, Verani JR. Intrapartum antibiotic prophylaxis for the prevention of perinatal group B Streptococcal disease: experience in the United States and implications for a potential group B Streptococcal vaccine[J]. Vaccine, 2013, 31(Suppl 4): D20-D26.
[8]
Johri AK, Lata H, Yadav P, et al. Epidemiology of group B Streptococcus in developing countries[J]. Vaccine, 2013, 31(Suppl 4): D43-D45.
[9]
Montagu D, Yamey G, Visconti A, et al. Where do poor women in developing countries give birth? A multi-country analysis of demographic and health survey data[J]. PLoS One, 2011, 6(2): e17155.
[10]
Edwards MS, Gonik B. Preventing the broad spectrum of perinatal morbidity and mortality through group B Streptococcal vaccination[J]. Vaccine, 2013, 31(Suppl 4): D66-D71.
[11]
Melin P. Neonatal group B Streptococcal disease: from pathogenesis to preventive strategies[J]. Clin Microbiol Infect, 2011, 17(9): 1294-1303.
[12]
Sweet LR, Gibbs RS.女性生殖道感染性疾病.董建春,王波,译.4版.济南:山东科学技术出版社,2012: 31-45.
[13]
漆洪波.《孕前和孕期保健指南(第1版)》解读[C]//中华围产医学杂志社.第三届围产医学新进展高峰论坛论文集,重庆,2011.
[14]
Verani JR, Schrag SJ. Group B Streptococcal disease in infants: progress in prevention and continued challenges[J]. Clin Perinatol,2010, 37(2): 375-392.
[15]
Verani JR, McGee L, Schrag SJ, et al. Prevention of perinatal group B Streptococcal disease-revised guidelines from CDC, 2010[J]. MMWR Recomm Rep, 2010, 59(RR-10): 1-36.
[16]
Edwards MS, Fuselier PA, Rench MA, et al. Class specificity of natural1y acquired and vaccine-induced antibody to type Ⅲ group B Streptococcal capsular polysaccharide: determination with a radioimmunoprecipitin assay[J]. Infect Immun, 1984, 44(2): 257-261.
[17]
Hunter SK, Andracki ME, Krieg AM. Biodegradable microspheres containing group B Streptococcal vaccine: immune response in mice[J]. Am J Obstet Gynecol, 2001, 185(5): 1174-1179.
[18]
Baker CJ, Rench MA, McInnes P. Immunization of pregnant women with group B Streptococcal type Ⅲ capsular polysaccharide-tetanus toxoid conjugate vaccine[J]. Vaccine, 2003, 21(24): 3468-3472.
[19]
Madhi SA, Cutland CL, Jose L, et al. Maternal group B Streptococcus vaccination results in placental antibody transfer without interfering with response to routine infant vaccination[J]. Vaccine, 2014, 31(16): 256-261.
[20]
Madhi SA, Dangor Z, Heath PT, et al. Considerations for a phase-Ⅲ trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of earlyand late-onset invasive disease in young-infants[J]. Vaccine, 2013, 31(Suppl 4): D52-D57.
[21]
Mahdi SA, Cutland CL, Jose L,et al. Safety and immunogenicity of an investigational maternal trivalent group B Streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial[J]. Lancet Infect Dis,2016, 16(8): 923-934.
[22]
Gray BM, Pritchard DG, Dillon HC. Seroepidemiological studies of group B Streptococcus type Ⅱ[J]. J Infect Dis, 1985, 151(6): 1073-1080.
[23]
Gray BM, Egan ML, Pritchard DG. The group B streptococci: from natural history to the specificity of antibodies[J]. Semin Perinatol, 1990, 14(Suppl 1): 10-21.
[24]
Lin FY, Philips JB, Azimi PH, et al. Level of maternal antibody required to protect neonates against early-onset disease caused by group B Streptococcus type Ⅰa:a multicenter seroepidemiology study[J]. J Infect Dis, 2001, 184(8): 1022-1028.
[25]
Lin FY, Weisman LE, Azimi PH, et al. Level of maternal IgG anti-group B Streptococcus type Ⅲ antibody correlated with protection of neonates against early-onset disease caused by this pathogen[J]. J Infect Dis, 2004, 190(5): 928-934.
[26]
Baker CJ, Carey VJ, Rench MA, et al. Maternal antibody at delivery protects neonates from early-onset group B Streptococcal disease[J]. J Infect Dis, 2014, 209(5): 781-788.
[27]
Gravekamp C, Kasper DL, Paoletti LC, et al. Alpha C protein as a carrier for type Ⅲ capsular polysaccharide and as a protective protein in group B Streptococcal vaccines[J]. Infect Immun, 1999, 67(5): 2491-2496.
[28]
Bohnsack JF, Widjaja K, Ghazizadeh S, et al. A role for C5 and C5a-ase in the acute neutrophil response to group B Streptococcal infections[J]. J Infect Dis, 1997, 175(8): 847-855.
[29]
Cheng Q, Carlson B, Pillai S, et al. Antibody against surface-bound C5a peptidase is opsonic and initiates macrophage killing of group B Streptococci[J]. Infect Immun, 2001, 69(4): 2302-2308.
[30]
Cheng Q, Debol S, Lam H, et al. Immunization with C5a peptidase or peptidase-type Ⅲ polysaccharide conjugate vaccines enhances learance of group B Streptococci from lungs of infected mice[J]. Infect Immun, 2002, 70(11): 6409-6415.
[31]
Larsson C, Stalhammar-Carlemalm M, Lindahl G. Experimental vaccination against group B Streptococcus, and encapsulated bacterium, with highly purified preparations of cell surface proteins Rib and alpha[J]. Infect Immun, 1996, 64(6): 3518-3523.
[32]
Shen X, Lagergård T, Yang Y, et al. Systemic and mucosal immune responses in mice after mucosal immunization with group B Streptococcus type Ⅲ capsular polysaccharide-cholera toxin B subunit conjugate vaccine[J]. Infect Immun, 2000, 68(10): 5749-5755.
[33]
Maione D, Margarit I, Rinaudo CD, et al. Identification of a universal group B Streptococcus vaccine by multiple genome screen[J]. Science, 2005, 309(15): 148-150.
[34]
Romero-Saavedra F, Laverde D, Wobser D, et al. Identification of peptidoglycan-associated proteins as vaccine candidates for enterococcal infections[J]. PLoS One, 2014, 9(11): e111880.
[35]
Fontana MR, Soriani M, Bagnoli F, et al. Protectome analysis: a new selective bioinformatics tool for bacterial vaccine candidate discovery[J]. Mol Cell Proteomics, 2015, 14(2): 418-429.
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