Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2016, Vol. 12 ›› Issue (05): 501 -505. doi: 10.3877/cma.j.issn.1673-5250.2016.05.002

Special Issue:

Editorial

Diagnosis and treatment of primary immunodeficiency diseases: an example of precision medicine

Xiqiang Yang1, Xiaodong Zhao1,()   

  1. 1. Department of Rheumatology and Immunology, Children′s Hospital of Chongqing Medical University, Chongqing 400014, China
  • Received:2016-07-30 Revised:2016-08-10 Published:2016-10-01
  • Corresponding author: Xiaodong Zhao
  • About author:
    Corresponding author: Zhao Xiaodong, Email:

Precision medicine is the inevitable trend of modern medical advance. Its basic principle is to find the molecular pathogenesis of the diseases, after then to look for targeted biomarkers in order to make the targeted therapy. In the article, taking X-linked agammaglobulinemia (XLA), one of the primary immunodeficiency diseases (PID) as an example, to illustrate that the diagnosis and treatment process of PID is based on the basic principle of precision medicine. The PID is a kind of heterogeneous diseases with very complex and diversity clinical phenotypes involving various clinical specialists. This article notes that both general and special pediatricians should not only to understand the clinical manifestations of the PID, but also do further genetic analysis and molecular biological mechanism studies. If so, clinical management of PID will be in accordance with the principle of precision medicine.

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