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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2016, Vol. 12 ›› Issue (03): 266 -273. doi: 10.3877/cma.j.issn.1673-5250.2016.03.004

Special Issue: ；

Original Article

Visualized study of fetal congenital heart disease in China based on co-word analysis

Ding Yun1, Yifei Li2, Chuan Wang1, Yi Zhang2, Tao Wang2, Hongyu Duan2, Dajian Qiu2, Xiaoqing Shi2, Kaiyu Zhou2, Dezhi Mu2, Yimin Hua2,†()   

  1. 1. Department of Pediatric Cardiovascula, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, Sichuan Province, China; West China School of Clinical Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Department of Pediatric Cardiovascula, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, Sichuan Province, China
  • Received:2016-04-29 Revised:2016-05-11 Published:2016-06-01
  • Corresponding author: Yimin Hua
  • About author:
    Corresponding author: Hua Yimin, Email:
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Objective

To study the development trend of research on fetal congenital heart disease(CHD) in China through a visualized network based on research key words of fetal CHD with the co-word and social network analysis.

Methods

The China Biology Medicine (CBM) and Chinese National Knowledge Infrastructure (CNKI) databases had been searched using the mesh keywords of"fetus"and"congenital heart disease"from January 1976 to December 2015, a total of 1 458 articles in accordance with the accepting criteria of this study were included as the research objects. Enrolled articles were divided into three stage groups as 1976-1995 year group, 1996-2005 year group and 2006-2015 year group.Collected the core key words and their words frequencies, then taken out the proper core key words from above stages with Endnote X7 software. The co-occurrence matrixes were built through Excel 2010, and the visualized networks were drawn using Ucinet 6.0. The connection and changes of domain subject knowledge of all core key words among 3 stage groups and their frequencies were observed and analyzed.

Results

The numbers of enrolled articles on fetal CHD of 3 stage groups above mentioned were 94, 182 and 1 182, respectively. The visualized network of fetal CHD study in China was successfully built.The key words of"prenatal examination"and"echocardiography"were in the central position of the social network in all 3 stage groups.A total of 20 core key words on fetal CHD were in 1976-1995 year group; 35 core key words were in 1996-2005 year group,"intrauterine growth retardation"gradually closed to central position, and the new words of"extracardial anomalies"and"pregnant disease"were first appeared and located in the second gradation; 55 core key words were in 2006-2015 year group, and the number of core key words increased in the central part including"heart defects","blood flow spectrum of ductus venosus"and"Tei index", etc., and new core key words mostly located on the edge area of the network.

Conclusions

The subject knowledge of fetal CHD originated from the middle 1970s in China. Taken the advantage of fetal echocardiography development, fetal CHD studies burst out in recent ten years.The knowledge of fetal CHD, prenatal diagnosis and assessment of fetus achieved remarkable progress.Now the clinic treatment of fetal cardiac intervention is still in the exploration stage and more prospective studies are needed.

Key words: Congenital heart disease, Co-word analysis, Visualized analysis, Fetus
图1 胎儿先天性心脏病研究文献量的年代分布
表1 1976－1995年组胎儿先天性心脏病核心关键词共词分析结果
核心关键词 词频(次) 核心关键词 词频(次) 核心关键词 词频(次)
超声心动图 36 室间隔缺损 8 三体 6
产前检查 23 心功能 8 羊膜腔穿刺 5
羊水异常 13 危险因素 7 心脏发育不良 4
心律失常 10 心脏缺损 7 血流动力学 4
染色体异常 10 宫内感染 7 血管发育异常 4
病毒 9 自然流产 7 遗传咨询 4
房间隔缺损 9 宫内发育迟缓 6 　 　
图2 1976－1995年组胎儿先天性心脏病核心关键词可视化网络图
表2 1996－2005年组胎儿先天性心脏病核心关键词共词分析结果
核心关键词 词频(次) 核心关键词 词频(次) 核心关键词 词频(次)
超声心动图 97 基因诊断 7 宫内感染 5
产前检查 35 唐氏综合征/三体 6 自然流产 5
心脏缺损 25 四腔心切面 6 血管发育异常 5
病毒 12 宫内发育迟缓 6 药物致畸 5
妊娠期疾病 12 心脏发育不良 6 筛查 5
出生缺陷 11 羊膜腔穿刺 6 高危妊娠 5
心外畸形 11 染色体异常 6 活产率/死亡率 5
心律失常 10 家族性/遗传性 6 血流动力学 4
危险因素 9 干预 6 发生率 4
监测 8 室间隔缺损 5 胎儿窘迫 4
羊水异常 8 房间隔缺损 5 心功能 4
围产儿 7 肺动脉瓣狭窄 5 　 　
图3 1996－2005年组胎儿先天性心脏病核心关键词可视化网络图
表3 2006－2015年组胎儿先天性心脏病核心关键词共词分析结果
核心关键词 词频(次) 核心关键词 词频(次) 核心关键词 词频(次)
超声心动图 375 静脉导管血流频谱 20 心脏发育不良 9
产前检查 135 心律失常 19 高危妊娠 9
心脏缺损 134 血管发育异常 19 预防 9
筛查 131 家族性/遗传性 19 大动脉转位 8
出生缺陷 100 房间隔缺损 18 终止妊娠 8
染色体异常 57 时空关联成像 18 宫内发育迟缓 8
干预 47 心功能 18 妊娠结局 6
监测 46 病例对照研究 16 脐带穿刺 6
动脉导管 42 永存动脉干 14 基因诊断 6
胎儿期 42 流行病学 14 病毒 6
心外畸形 41 法洛四联症 12 自然流产 6
室间隔缺损 38 肺动脉瓣狭窄/肺动脉闭锁 12 Tei指数 5
围产儿 34 诊断价值 12 血清学 5
危险因素 31 妊娠期疾病 11 药物致畸 5
四腔心切面 29 单核苷酸多态性 11 随访 5
发生率 28 宫内感染 11 胎儿窘迫 5
颈项透明层 25 基因突变 10 羊水异常 4
唐氏综合征/三体 24 双胎 10 　 　
活产率/死亡率 21 血流动力学 9 　 　
图4 2006－2015年组胎儿先天性心脏病核心关键词可视化网络图
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