Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2016, Vol. 12 ›› Issue (01): 114 -117. doi: 10.3877/cma.j.issn.1673-5250.2016.01.021

Special Issue:

Review

Research progress of the association of killer cell immunoglobulin-like receptor 2DS4 alleles and diseases

Mingyan Jiang1   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-11-18 Revised:2016-01-10 Published:2016-02-01
  • About author:
    Corresponding author: Li Qiang, Email:

The killer cell immunoglobulin-like receptors (KIR), which are mainly expressed on the surface of natural killer (NK) cells and some populations of T cells, regulate the activity of NK cells. KIR genes are highly polymorphic, which result in different KIR haplotypes. The group A haplotypes carry only one activating KIR gene, KIR2DS4, which often has a 22 bp deletion in exon 5 and encodes a soluble nonfunctional receptor KIR1D. KIR2DS4 has specific gene structures, haplotype and population distribution, thus plays an important role in the association of KIR genes and diseases. Here we summarize recent research progress in light of the association of KIR2DS4 alleles and diseases.

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