Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (4): 547 -549. doi: 10.3877/cma.j.issn.1673-5250.2015.04.024

Special Issue:

Review

Effects of matrix metalloproteinase-2, -9 on neonatal brain injury caused by intrauterine infection

Dandan Chen   

  1. Department of Obstetrics and Gynecology, Clinical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-05-10 Revised:2015-07-02 Published:2015-08-01

Intrauterine infection is closely related to premature rupture of membranes(PROM), and these factors can greatly increase the incidence of neonatal brain injury.At present, the mechanism of neonatal brain injury caused by intrauterine infection is not yet clear. Matrix metalloproteinase (MMP)-2, -9 not only participate in inflammation, destruction of membranes, but also take part in the disruption of the blood-brain barrier, then lead to the occurrence of neonatal brain injury. The value of predicting the occurrence of neonatal brain injury through the expression of MMP-2, -9 in mother's and fetal blood circulation and neonatal injury cerebral white matter with intrauterine infection are reviewed in this paper.

[1]
鲍珊,陈大鹏,杨晓燕,等.我国早产儿脑损伤研究现状——基于国内期刊的共词分析[J].中国新生儿科杂志201328(6):366–370.
[2]
del Zoppo GJ, Frankowshi H, Gu YH, et al. Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation[J].J Cereb Blood Metab201232(5):919–932.
[3]
李雁,陈曼诗,曾晓娟,等.转录因子Ets-1和基质蛋白酶-9在胎膜早破中表达意义[J].中华实用诊断和治疗杂志201428(7):658–659.
[4]
谢幸,苟文丽,主编. 妇产科学.8版[M].北京:人民卫生出版社,2013:94–95.
[5]
Saira D, Safi M, Irum S, et al. Maternal morbidity and perinatal outcome in preterm premature rupture of membranes before 37 weeks gestation[J]. Pak J Med Sci201430 (3):626–629.
[6]
Jeon Y, Jung Y, Youm JK, et al. Abietic acid inhibits UVB-induced MMP-1 expression in human dermal fibroblast cells through PPAR / dual activation[J]. Exp Dermatol201524(2):140–145.
[7]
Zaga-Clavellina V, Garcia-Lopez G, Flores-Pliego A,et al. In vitro secretion and activity profiles of matrix metalloproteinases, MMP-9 and MMP-2, in human term extra-placental membranes after exposure to Escherichia coli[J]. Reprod Biol Endocrinol20119:13.
[8]
Burd IBalakrishnan BKannan S. Models of fetal brain injury,intrauterine inflammation,and preterm birth[J]. Am J Reprod Immunol201267(4):287–294.
[9]
Fuller GW, Lawrence T, Woodford M, et al. The accuracy of alternative triage rules for identification of significant traumatic brain injury: a diagnostic cohort study[J]. Emerg Med J201431(11):914–919.
[10]
Back SA, Riddle A, McClure MM.Maturation-dependent vulnerability of perinatal white matter in premature birth[J].Stroke200738(2):724–730.
[11]
何亚芳,陈惠金,钱龙华,等.脂多糖诱导小鼠脑组织小胶质细胞激活的跨膜转导机制[J].实用儿科临床杂志201025(12):885–888.
[12]
Hsieh HL, Lin CC, Shih RH,et al. NADPH oxidase-mediated redox signal contributes to lipoteichoic acid-induced MMP-9 upregulation in brain astrocytes[J]. J Neuroinflammation20129:110.
[13]
Furukawa S, Sameshima H, Lkenoue T.Criculatory disturbances during the first postnatal 24 hours in extreely premature infants 25 weeks or less of gestation with histological fetal inflammation[J].J Obstet Gynaecol Res200834(1):27–33.
[14]
郝玲,邓彦东,王娜.胎膜早破早产儿脑血流动力学变化及其脑损伤的关系[J].中国实用儿科学杂志201429(1):55–57.
[15]
Elovitz MA, Brown AG, Breen K, et al. Intrauterine inflammation, insufficient to induce parturition, still evoke fetal and neonatal brain injury[J]. Int J Dev Neurosci2011, 29(6):663–671.
[16]
Sumio F, Kyoko Y, Kyoko K, et al. Influence of premature rupture of membrane on the cerebral blood flow in low-birth-weight infant after the delivery[J]. Brain Dev2010, 32(8):631–635.
[17]
Soraisham ASTrevenen CWood S, et al.Histological chorioamnionitis and neurodevelopmental outcome in preterm infants[J]. J Perinatol201333(1):70–75.
[18]
Suofu Y, Clark JF, Broderick JP, et al. Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion[J].Neuroscience2012212:180–189.
[19]
屈传强,焉传祝,陈裴.基质金属蛋白酶在脑白质疏松症血-脑脊液屏障机制的实验研究[J].山东大学学报:医学版201250(10):23–27.
[20]
Leonardo CCPennypacker KR.Neuroinflammation and MMPs:potential therapeutic targets in neonatal hypoxic-ischemic injury[J].J Neuroinflammation2009:6–13.
[21]
Nagel S, Su Y, Horstmann S, et al. Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase[J]. Brain Res20081188:198–206.
[22]
Park KP, Rosell A, Foerch C, et al. Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats[J]. Stroke2009, 40(8):2836–2842.
[23]
Ayush B, Lawrence LL, Christl AR, et al. Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post -contrast FLAIR after experimental stroke[J].J Cereb Blood Flow Metab2010, 30(6):1188–1199.
[24]
Burd I, Bentz AI, Chai J, et al. Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain[J].J Neurosci Res201088(9):1872–1881.
[1] Yingying Kong, Lutao Xie, Xiaochi Lu, Jiefeng Xu, Guangju Zhou, Mao Zhang. Protective effect and mechanism of sodium butyrate on cardio-brain injury after cardiac arrest resuscitation in pigs[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2023, 16(05): 355-362.
[2] Li Liu, Cheng Chen, Xinke Li, Kai Liu, Changming Tu. Value analysis of serum IL-6, hs-CRP and MMP-9 in the prognosis evaluation of inguinal hernia[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2023, 17(04): 405-409.
[3] Zechao Zhu, Xinyu Yang, Youcheng Li, Pengyu Pan, Guobiao Liang. Impact of genistein on early brain injury following subarachnoid hemorrhage in mice via the SIRT1/p53 signaling pathway[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(05): 261-269.
[4] Feixiang Li, Hubin Duan, Jinhu Li, Hao Wu, Yonghong Wang, Yimin Fan. Analysis of related risk factors and construction of prediction model for venous thrombosis of lower limbs secondary to acute traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(05): 277-282.
[5] Li Pan, Lizheng Xie, Hongwei Cheng, Xiang Mao. Hypopituitarism after traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(05): 308-312.
[6] Jingjing Wang, Feng Fu, Jianwei Li, Dangli Ren, Chong Chen, Hui Liu, Hongtao Sun, Yue Tu. Effect of acupuncture on BDNF/TrkB signaling pathway after moderate traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(04): 199-205.
[7] Xinyue Zhang, Shuai Han, Shushi Zhang, Wenchen Li, Shuyan Zhang. Application of intracranial pressure monitoring technique in the treatment of traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(04): 246-252.
[8] Zhao Wang, Jinjie Tian, Zhao Guo, Lei Wang, Hongyan Yan, Sujuan Feng, Yi Zhang. Predictive values of early detection of plasma PGK1 on the severity and prognosis of patients with traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(03): 154-159.
[9] Jinglei Ji, Xiuli Li, Yanan Jia, Huimin Feng, Liyan Liu. Evaluation of brain injury in high-risk full-term low body weight newborns by modified aEEG scores[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(03): 165-169.
[10] Jiawei He, Liang Zhang, Qi Yang, Zhanxiang Wang. Current status of diagnosis and treatment of progressive hemorrhagic injury after traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(03): 175-179.
[11] Suying Jia, Qian Li, Shanshan Guo. Research progress on platelet dysfunction after traumatic brain injury[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(03): 180-185.
[12] Yongming Zhang. Progress in the treatment of chronic consciousness disorders after traumatic brain injury with cervical spinal cord electrical stimulation[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(03): 129-134.
[13] Jiyun Hu, Shucai Xie, Lina Zhang. Advancement of S100 calcium binding protein B in neurocritical care field[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(03): 298-303.
[14] Mo Yun, Maofang Li, Hao Wang, Dongyuan Liu. Clinical study of minimally invasive puncture and drainage combined with piracetam and urapidil in the treatment of hypertensive intracerebral hemorrhage in basal ganglia[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(05): 278-285.
[15] Yu Zhang, Yujie Cai, Riqing Lin, Qinjie Qiu, Lili Cui, Dong Zheng, Haihong Zhou. Effect of TNS1 on cognitive function in mice with radiation-induced brain injury[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(03): 244-253.
Viewed
Full text


Abstract