Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (4): 547 -549. doi: 10.3877/cma.j.issn.1673-5250.2015.04.024

Special Issue:

Review

Effects of matrix metalloproteinase-2, -9 on neonatal brain injury caused by intrauterine infection

Dandan Chen   

  1. Department of Obstetrics and Gynecology, Clinical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-05-10 Revised:2015-07-02 Published:2015-08-01

Intrauterine infection is closely related to premature rupture of membranes(PROM), and these factors can greatly increase the incidence of neonatal brain injury.At present, the mechanism of neonatal brain injury caused by intrauterine infection is not yet clear. Matrix metalloproteinase (MMP)-2, -9 not only participate in inflammation, destruction of membranes, but also take part in the disruption of the blood-brain barrier, then lead to the occurrence of neonatal brain injury. The value of predicting the occurrence of neonatal brain injury through the expression of MMP-2, -9 in mother's and fetal blood circulation and neonatal injury cerebral white matter with intrauterine infection are reviewed in this paper.

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