Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (03): 411 -414. doi: 10.3877/cma.j.issn.1673-5250.2015.03.027

Special Issue:

Review

Research progress of the relationship between asymmetric dimethylarginine and early onset severe preeclampsia

Xi Cheng1()   

  1. 1. Department of Gynecology and Obstetrics, Maternal and Child Health Care Hospital, Guangzhou Medica University, Guangzhou 511400, Guandong Province, China
  • Received:2014-10-29 Revised:2015-05-13 Published:2015-06-01
  • Corresponding author: Xi Cheng
  • About author:
    Corresponding author: Cheng Xi, Email:

As an endogenous nitric oxide synthase(NOS) competitive inhibitor, asymmetric dimethylarginine(ADMA) can inhibit the activity of NOS, reduce the synthesis of nitric oxide(NO) and results in endothelial cell dysfunction.Early onset severe preeclampsia (EOSP) exists placental morphological abnormalities, and late onset severe preeclampsia (LOSP) has no obvious placental morphological abnormalities, so the genesis and formation of abnormal placenta may be the cause of EOSP.The dimethylarginine dimethylaminohydrolase(DDHA)2 expression level of placental vascular endothelial cells in EOSP patient descended, and cause ADMA degradation reduced.Increased ADMA expression level of plasma and placenta can competitively inhibit NOS activity, resulting in reduction of NO generate and NO bioavailability, causing placental lesions and dysfunction of placental vascular endothelial cells.It can be seen that ADMA is closely related to genesis and development of placental pathological changes in EOSP, and the fields in research of ADMA and EOSP have become a hot research topic now.This paper focused on the role and its possible mechanism of ADMA in EOSP.

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