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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (03): 306 -312. doi: 10.3877/cma.j.issn.1673-5250.2015.03.005

Special Issue: ；

Original Article

Visualized analysis of progress in neonatal septicemia in China through co-word analysis method

Zhongqiang Liu1, Xihong Li1(), Deyuan Li1, Lili Luo1, Guoyan Lu1, Dezhi Mu1()   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-03-15 Revised:2015-05-05 Published:2015-06-01
  • Corresponding author: Xihong Li, Dezhi Mu
  • About author:
    Corresponding author: Mu Dezhi, Email:
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Objective

To study the progress of neonatal septicemia(NS) by using co-word and social network analysis in China, then build visualized network and predict the development trends in the future.

Methods

From January 1st 1960 to May 28th 2014, a total of 1 719 articles about NS from China Biology Medicine (CBM) disc and Chinese National Knowledge Infrastructure (CNKI) were found out according to the keywords"neonatal","septicemia". They were divided into stage 1960-1993, stage 1994-2003, stage 2004-2014 by Endnote X6. The core-key words were taken out from 3 stages and the co-occurrence matrix was built by Bicom 2. Then visualized network was drawn by Ucinet 6.0.The differences between core-key words frequency and its correlation were compared.

Results

The number of articles in 3 stages were 257, 655, 807, respectively.They were published in 401 kinds of medical journals, and the number of author's affiliation were 477.The visualized network of NS in China was successfully built, and it directly reflected the changes of hot topics in this field. The NS research at stage 1960-1993 were focus on its clinical recognition.Diagnosis and treatment of NS were much accounted at stage 1994-2003. The NS research at stage 2004-2014 mainly dedicated to early detection of infection index, drug-resistance bacteria and antibiotic application of NS.

Conclusions

The research of NS in China started in the 1960s, and had made great progress after 1994. The definition and diagnosis of NS changes consistent with abroad. At present, the current diagnostic studies pay more attention to the clinical manifestations and early infection index selection, with the decline in the proportion of blood culture of bacteria. Antibiotic resistance research is one of the research hotspots in NS therapy, immunotherapy research has declined in the number of recent 10 years but still is of further study value.

Key words: Neonatal septicemia, Sepsis, Co-word analysis, Visualized analysis
图1 NS研究的年代分布
Figure 1 Year distribution of NS articles
表1 发表NS相关文献的期刊分布情况
Table 1 Distribution of medical journals with NS articles
期刊名称 文献数量(篇) 期刊名称 文献数量(篇)
《新生儿科杂志》 78 《中国妇幼保健》 15
《实用儿科临床杂志》 58 《中华医院感染学杂志》 15
《临床儿科杂志》 57 《临床医学》 13
《中国新生儿科杂志》 29 《实用医学杂志》 13
《中国实用儿科杂志》 26 《中国社区医师(医学专业)》 13
《安徽医学》 21 《儿科药学杂志》 12
《国际检验医学杂志》 21 《新医学》 12
《临床检验杂志》 21 《中国儿童保健杂志》 12
《中国优生与遗传杂志》 21 《广东医学》 11
《山东医药》 20 《上海医学检验杂志》 11
《中国社区医师》 19 《现代中西医结合杂志》 11
《中国误诊学杂志》 18 《中国医药指南》 11
《中华儿科杂志》 18 《工企医刊》 10
《实用儿科杂志》 17 《国外医学(儿科学分册)》 10
《中国当代儿科杂志》 16 《吉林医学》 10
《重庆医学》 16 《浙江预防医学》 10
《福建医药杂志》 15 《中国实用医药》 10
《小儿急救医学》 15 《中国微生态学杂志》 10
表2 发表NS相关文献的作者单位分布情况
Table 2 Distribution of author's affiliation with NS articles
作者单位名称 文献数量(篇) 作者单位名称 文献数量(篇)
浙江大学医学院附属儿童医院 48 安徽医科大学附属省立医院 11
重庆医科大学附属儿童医院 18 北京大学第一医院 11
第三军医大学大坪医院 17 哈尔滨市儿童医院 10
河南省儿童医院 14 河南新乡医学院 10
南京市儿童医院 14 四川大学华西第二医院 10
广州市儿童医院 12 复旦大学附属医院 10
图2 1965-1993年阶段NS高频关键词可视化网络
Figure 2 The visualized network of high frequency keywords of NS in stage 1965-1993
表3 1960－1993年阶段的关键词共词分析结果
Table 3 Result of co-word and social network analysis in stage 1960-1993
关键词 词频(次) 关键词 词频(次) 关键词 词频(次)
新生儿败血症 253 免疫 25 体温不升 15
血培养 129 病死率 25 脑脊液 13
临床分析 106 治疗 22 C反应蛋白 13
抗菌药物 94 早产儿 22 药敏试验 13
病原菌 76 细菌感染 22 耐药性 13
感染 52 皮肤感染 21 呼吸道感染 11
发病率 44 高胆红素血症 21 致病性 10
诊断 42 产科异常 21 脐部感染 10
疾病 41 死亡率 20 体温 10
新生儿 35 感染途径 19 实验室检查 9
白细胞 34 细菌 19 病情观察 10
化脓性脑膜炎 33 感染疾病 17 血红蛋白 10
中性粒细胞 30 并发症 17 ? ?
图3 1994-2003年阶段NS高频关键词可视化网络
Figure 3 The visualized network of high frequency keywords of NS in stage 1994-2003
表4 1994－2003年阶段的关键词共词分析结果
Table 4 Result of co-word and social network analysis in stage 1994-2003
关键词 词频(次) 关键词 词频(次) 关键词 词频(次)
新生儿败血症 641 细菌 28 胎膜早破 14
抗菌药物 302 感染性休克 27 体温不升 14
新生儿 224 细菌感染 24 产科异常 14
病原菌 202 低出生体重儿 23 病例分析 14
疾病 179 中性粒细胞 22 羊水异常 13
血培养 177 高胆红素血症 22 疗效 13
临床分析 150 C反应蛋白 21 菌株分析 13
药敏试验 106 白细胞 20 院内感染 12
治疗 89 病死率 20 降钙素原 12
诊断 82 肿瘤坏死因子 20 胆红素 12
感染 81 并发症 20 皮肤感染 12
早产儿 74 多器官功能障碍综合征 19 病因 11
耐药性 43 死亡率 18 换血疗法 11
免疫疗法 40 脓毒症 17 危险因素 10
呼吸道感染 36 脐部感染 16 妇幼保健 10
护理 33 全身炎症反应综合征 16 呼吸窘迫综合征 10
免疫 31 发病率 14 感染途径 10
化脓性脑膜炎 29 母乳喂养 14 ? ?
图4 2004-2014年阶段NS高频关键词网络
Figure 4 The visualized network of high frequency keywords of NS in stage 2004-2014
表5 Result of co-word and social network analysis in stage 2004-2014
Table 5
关键词 词频(次) 关键词 词频(次) 关键词 词频(次)
新生儿败血症 698 白细胞 44 晚发型 18
新生儿 516 危险因素 43 血小板 18
病原菌 372 高胆红素血症 41 并发症 17
抗菌药物 226 胎膜早破 38 疗效 17
诊断 205 多器官功能障碍综合征 37 感染性休克 17
血培养 205 死亡率 35 病因 15
C反应蛋白 197 感染疾病 34 皮肤感染 14
降钙素原 183 中性粒细胞 34 血糖 14
耐药性 178 细菌 32 实验室检查 13
感染 167 病死率 31 糖皮质激素 12
临床分析 154 脐部感染 31 呼吸窘迫综合征 12
疾病 127 化脓性脑膜炎 31 换血疗法 12
脓毒症 121 发病率 28 坏死性小肠结肠炎 12
早产儿 113 院内感染 28 羊水异常 12
治疗 105 早发型 27 极低出生体重儿 12
药敏试验 82 预后 24 药理 12
细菌感染 64 产科异常 23 真菌感染 12
护理 54 呼吸道感染 20 ? ?
全身炎症反应综合征 54 病毒感染 19 ? ?
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