Influence of adverse environmental factors on premature ovarian failure

doi:10.3877/cma.j.issn.1673-5250.2015.02.008

Objective

To study influence of adverse environmental factors on premature ovarian failure (POF), providing good preventive and health care concept for women, reducing the occurrence of POF.

Methods

From March 2008 to March 2013, a total of 60 cases of POF patients who were diagnosed as POF in out-patient clinic of Department of Reproductive Endocrinology in West China Second University Hospital, Sichuan University were included into POF group. During the same period, a total of 60 cases who took physical examination in the same hospital with normal ovarian function were included into control group. Self-designed"Adverse Environmental Factors Exposure Questionnaire"was used to investigate both two groups. And the survey items included: ① exposure to environmental endocrine disruptors (chemical factors), such as hair dye, cosmetics, interior decoration materials, cigarettes and alcohol; ② exposure to electromagnetic radiation, such as microwave ovens, induction cooker, mobile phones and computers. The exposure to adverse environmental factors between groups were analyzed by statistical methods. There were no significant differences between POF group and control group among age, occupation, age of menarche, menstrual history, obstetrical history and so on (P> 0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital, Sichuan University. Informed consent was obtained from all participants.

Results

The rate of exposure to chemical factors in POF group was significantly higher than that in control group, and there were significant differences(χ²=30.86, P<0.05); The rate of exposure to electromagnetic radiation in POF group was significantly higher than that in control group, and there were significant differences either (χ²=33.41, P<0.05).

Conclusions

Exposure to adverse environmental factors is likely to be one of the risk factors of POF. It is important for women to pay attention to adverse effects of environmental factors on POF, and actively avoid the adverse environmental factors in order to prevent occurrence of POF.

Key words: Ovarian failure, premature, Questionnaires, Hazardous substances, Electromagnetic radiation, Adverse environmental factors, Women's health care

表1 两组受试者一般临床资料比较(±s)

Table 1 Comparison of general clinical data between two groups (±s)

组别	例数	年龄(岁)	月经初潮年龄(岁)	既往月经周期(d)	产次(次)
POF组	60	31.8±4.6	11.8±2.5	4.8±1.3	0.7±0.6
对照组	60	30.0±5.4	12.4±2.1	5.0±1.2	0.7±0.6
t值	?	－1.966	1.268	0.877	－0.143
P值	?	0.052	0.207	0.382	0.886

表1 两组受试者一般临床资料比较(±s)

Table 1 Comparison of general clinical data between two groups (±s)

组别	例数	年龄(岁)	月经初潮年龄(岁)	既往月经周期(d)	产次(次)
POF组	60	31.8±4.6	11.8±2.5	4.8±1.3	0.7±0.6
对照组	60	30.0±5.4	12.4±2.1	5.0±1.2	0.7±0.6
t值	?	－1.966	1.268	0.877	－0.143
P值	?	0.052	0.207	0.382	0.886

表2 两组间环境内分泌干扰物暴露情况比较[例数(%)]

Table 2 Comparison of the exposure to environmental endocrine disruptors between two groups [case(%)]

组别	例数	有暴露史所占比例
POF组	60	40(66.7)
对照组	60	10(16.7)
χ²值	?	30.86
P值	?	0.000

表2 两组间环境内分泌干扰物暴露情况比较[例数(%)]

Table 2 Comparison of the exposure to environmental endocrine disruptors between two groups [case(%)]

组别	例数	有暴露史所占比例
POF组	60	40(66.7)
对照组	60	10(16.7)
χ²值	?	30.86
P值	?	0.000

表3 两组间电磁辐射暴露情况比较[例数(%)]

Table 3 Comparison of the exposure to electromagnetic radiation between two groups [case(%)]

组别	例数	有暴露史所占比例
POF组	60	58(96.7)
对照组	60	30(50.0)
χ²值	?	33.41
P值	?	0.000

表3 两组间电磁辐射暴露情况比较[例数(%)]

Table 3 Comparison of the exposure to electromagnetic radiation between two groups [case(%)]

组别	例数	有暴露史所占比例
POF组	60	58(96.7)
对照组	60	30(50.0)
χ²值	?	33.41
P值	?	0.000

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