To investigate the clinic features of postpartum hemolytic uremic syndrome (PHUS) for early diagnosis, prompt therapy and better prognosis.

A retrospective study was conducted on clinical data of 6 PHUS patients with gestational age over 33 weeks in Suzhou Hospital Affiliated to Nanjing Medical University from January 2008 to December 2012. Clinical symptoms and signs, hemolytic uremic related indexes, ultrasonograph and peripheral blood smear of them were analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Suzhou Hospital Affiliated to Nanjing Medical University.

All 6 patients had pregnancy combined with severe preeclampsia. After antispasmodic, antihypertensive treatment and promot fetal lung mature, they gave birth by cesarean section, and no neonatal death. The main symptoms were gradually oliguria and anuria without remote cause, hemolytic anemia, thrombocytopenia and sharp decline of renal function after 1-2 days of cesarean section. Through comprehensive treatment based on continuous renal replacement therapy (CRRT) and plasma exchange, the patient's conditions were stable and improved, and all patients were discharged from hospital. After 1 year follow up, 3 cases(50.0%) were lost to follow up, l case (16.7%) with chronic renal insufficiency.

Preeclampsia is one of the important remote causes of PHUS. It's necessary to strengthen renal function monitoring of pregnant women with preeclampsia after childbirth, in order to make early diagnosis and give specialized treatment in time, which are significant measures to reduce maternal mortality and ensure mother's healthy.