Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2014, Vol. 10 ›› Issue (04): 469 -472. doi: 10.3877/cma.j.issn.1673-5250.2014.04.014

Special Issue:

Original Article

Effects of Clinical Pharmacist Intervention on the Use of Antibacterials During Perioperative Period of Cesarean Section

Ying Chang1, Heng Zhang1, Yan Song2, Xiaolin Shi1()   

  1. 1. Department of Pharmacy, Shaanxi Marternal and Child Hospital, Xian 710003, Shaanxi Province, China
  • Received:2014-01-09 Revised:2014-03-14 Published:2014-08-01
  • Corresponding author: Xiaolin Shi
  • About author:
    (Corresponding author: Shi Xiaolin, Email: )
Objective

To evaluate the effects of clinical pharmacist intervention on the use of antibacterials during perioperative period of cesarean section.

Methods

The patients with cesarean section who were not receive clinical pharmacist intervention on the use of antibacterials during perioperative period from July to September 2012 in Shaanxi Martenal and Child Hospital were chosen into non-intervention group(n= 136). The patients with cesarean section who received clinical pharmacist intervention on the use of antibacterials during perioperative period from July to September 2013 in the same hospital were chosen into intervention group(n= 145). The rationality of prophylactic use of antibacterials during perioperative period and effects of hospitalization were compared, retrospectively. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Shaanxi Marternal and Child Hospital. Informed consent was obtained from each participating patient. The average age, operation duration and the amount of bleeding had no significant differences between two groups (P> 0.05).

Results

After the intervention of clinical pharmacist, the rationality of choice of medicine and medication time of the preventive application of antibacterials during perioperative period were statistically improved compared with those of non-intervention(χ2 = 6.30,221.38; P = 0.01,0.00). While the time points of prophylaxis use of antibacterials and mean hospital days had no significant differences between two groups(χ2/t= 1.36, 1.60; P=0.24,0.11). The per capita antibacterial expense, per capita total medicine expense and per capita total hospitalization expense were statistically lower after intervention (t = 28.99,5.10, 4.23; P = 0.00, 0.00, 0.00).

Conclusions

The rationality of use of antibacterials during perioperative period of cesarean section were significantly improved after clinical pharmacist intervention, which could reduce hospitalization expense. The clinical pharmacist intervention on the preventative application of antibacterials is feasible and effective.

表1 围手术期预防应用抗菌药物合理性评价标准
Table 1 The reasonable criterion of prophylactic use of antibacterials during perioperative period
表2 两组抗菌药物使用种类及构成比[n(%)]
Table 2 The types of antibacterials and their constituent ratio of two groups[n(%)]
表3 两组抗菌药物用药时机、术后用药时间及其构成比[n(%)]
Table 3 The antibacterials use time and postoperative medication time and their constituent ratio of two groups[n(%)]
表4 两组抗菌药物合理使用率比较[n(%)]
Table 4 Comparison of reasonable use rate of antibacterials of two groups[n(%)]
表5 两组患者平均住院时间及各项费用比较(±s)
Table 5 Comparison of mean hospital days and all the expenses of patients of two groups (±s)
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