To discuss effectiveness by zhibai dihuang pill combined dabuyin pill to children with central precocious puberty (CPP).

From August 2011 to April 2013, a total of 56 cases of children with CPP were recruited. According to different strategies for treatment they were divided into treatment group (n=28; age <5-year-old children taking zhibai dihuang pill 54 g (9 g/grain) bis in die + dabuyin pill 180 g (9 g/grain) bis in die; ≥5-year-old children taking zhibai dihuang pill (72-90)g bis in die+ dabuyin pill 360 g bis in die, 6 months continuous treatment) and control group (n=28; only taking zhibai dihuang pill, dosage and course of treatment the same as treatment group). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Children's Hospital of Zhengzhou. Informed consent was obtained from the parents of each participating child. There were no significance difference between two groups among age, gender, course of disease, type of precocious puberty, gonadotropin levels etc.(P>0.05).

Follow-up 6 months after treatment, there were significance difference between two groups among efficiencies, effectivenesses, in efficiencies and total effective rates (78.5% vs. 57.1%, 14.3% vs 17.9%, 7.2% vs. 25.0%, 92.8% vs. 75.0%; χ²=3.546, 2.314, 2.597, 12.114; P<0.05).

Curative effect of zhibai dihuang pill combined dabuyin pill is good for treatment children with CPP in this study. But whether it is worthy of clinical application multi-center, large-sample randomized controlled trial will be needed to further confirm the safety and effectiveness, etc..