Curative Effect Analysis of Different Doses of Intravenous Immunoglobin for Children With Severe Hand Foot and Mouth Disease Combined With Encephalitis

doi:10.3877/cma.j.issn.1673-5250.2013.02.018

Objective

To explore the curative effect of different doses of intravenous immunoglobin(IVIG) in children with severe hand foot and mouth disease(HFMD) combined with encephalitis.

Methods

From June to September 2012, 75 children with severe HFMD combined with encephalitis were included in the study, and randomly divided into group A(n=25), group B(n=25)and group C(n=25). Besides mannitol, methylprednisolone and other supportive treatments, different doses of IVIG were given in three groups respectively. The curative effect was compared among three groups.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of People's Hospital of Jimo.Informed consent was obtained from each parents. There was no significant difference in age, disease course and sex among three groups (P>0.05).

Results

There had significant differences in curative effect among three groups(P₁<0.05). There was no significant difference in curative effect between group B and group C(P₂>0.05).

Conclusions

High-dose IVIG was effective to children with severe HFMD combined with encephalitis, it can relief the symptoms quikly, shorten the course of the disease, avoid the progress of the disease and decrease the incidence rate of complications.

Key words: intravenous immunoglobin, dose, hand foot and mouth disease, severe case, encephalitis

表1 3组患儿一般资料比较(±s)

Table 1 Comparison of general condition among three groups(±s)

组别	n	性别[n(%)]		年龄(岁)	病程(d)
组别	n	男	女	年龄(岁)	病程(d)
A组	25	15(60.0)	10(40.0)	1.78±0.85	2.60±0.50
B组	25	12(48.0)	13(52.0)	1.92±1.21	2.48±0.51
C组	25	14(56.0)	11(44.0)	2.38±0.94	2.40±0.50
χ²/F		0.365		2.367	1.000
P		0.695		0.101	0.373

表1 3组患儿一般资料比较(±s)

Table 1 Comparison of general condition among three groups(±s)

组别	n	性别[n(%)]		年龄(岁)	病程(d)
组别	n	男	女	年龄(岁)	病程(d)
A组	25	15(60.0)	10(40.0)	1.78±0.85	2.60±0.50
B组	25	12(48.0)	13(52.0)	1.92±1.21	2.48±0.51
C组	25	14(56.0)	11(44.0)	2.38±0.94	2.40±0.50
χ²/F		0.365		2.367	1.000
P		0.695		0.101	0.373

表2 3组患儿临床疗效比较(h，±s)

Table 2 Comparison of clinical effect among three groups(h，±s)

组别	n	发热缓解时间	肢体抖动缓解时间	精神恢复时间	临床治愈时间	治疗无效患者数[n(%)]
A组	25	2.32±0.48	2.20±0.41	3.28±0.46	6.12±0.60	0(0.0)
B组	25	3.04±0.54	3.56±0.50	4.12±0.60	8.12±0.62	2( 8.0)
C组	25	3.08±0.57	3.68±0.45	4.20±0.65	8.52±0.65	6(24.0)
F/χ²		16.269	80.551	19.473	106.776	4.200
P₁		<0.01	<0.01	<0.01	<0.01	<0.05
t		0.253	0.881	0.419	1.089	1.445
P₂		0.802	0.387	0.679	0.083	0.163

表2 3组患儿临床疗效比较(h，±s)

Table 2 Comparison of clinical effect among three groups(h，±s)

组别	n	发热缓解时间	肢体抖动缓解时间	精神恢复时间	临床治愈时间	治疗无效患者数[n(%)]
A组	25	2.32±0.48	2.20±0.41	3.28±0.46	6.12±0.60	0(0.0)
B组	25	3.04±0.54	3.56±0.50	4.12±0.60	8.12±0.62	2( 8.0)
C组	25	3.08±0.57	3.68±0.45	4.20±0.65	8.52±0.65	6(24.0)
F/χ²		16.269	80.551	19.473	106.776	4.200
P₁		<0.01	<0.01	<0.01	<0.01	<0.05
t		0.253	0.881	0.419	1.089	1.445
P₂		0.802	0.387	0.679	0.083	0.163

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