Clinical Analysis of 146 Children With Severe Hand Foot and Mouth Disease

doi:10.3877/cma.j.issn.1673-5250.2013.01.020

Objective

To investigate the clinical features of hand foot and mouth disease(HFMD), and provide the basis of diagnosis and treatment.

Methods

From May 2010 to April 2012, 146 children with severe HFMD were included in the study. The clinical features, laboratory examinations, hospitalization time and the results of clinical treatment were analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Xiangyang Centre Hospital.Informed consent was obtained from each parents.

Results

All severe HFMD patients had fever and skin rash in the study(100.0%), and 95.9% of them had weakness, limb shaking and sleepiness as well. The pathogenic examination results showed that 80 patients (54.8%)were positive in EV 71, 35 patients(24.0%) were positive in Cox A16, and 25 patients(17.1%) were positive in both of them.The treatment outcomes showed that 135 patients(92.5%) were cured, 5 patients(3.4%) were improved, 6 patients(4.1%) were dead.

Conclusions

The main symptoms of severe HFMD are fever, skin rash, weakness, limb shaking and sleepiness. The pathogenic examination is helpful to the diagnosis of HFMD. Early detection and intervention are the key point of treatment of severe HFMD.

Key words: hand foot and mouth disease, severe, neurogenic pulmonary edema

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