Clinical Analysis of 146 Children With Severe Hand Foot and Mouth Disease

doi:10.3877/cma.j.issn.1673-5250.2013.01.020

Objective

To investigate the clinical features of hand foot and mouth disease(HFMD), and provide the basis of diagnosis and treatment.

Methods

From May 2010 to April 2012, 146 children with severe HFMD were included in the study. The clinical features, laboratory examinations, hospitalization time and the results of clinical treatment were analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Xiangyang Centre Hospital.Informed consent was obtained from each parents.

Results

All severe HFMD patients had fever and skin rash in the study(100.0%), and 95.9% of them had weakness, limb shaking and sleepiness as well. The pathogenic examination results showed that 80 patients (54.8%)were positive in EV 71, 35 patients(24.0%) were positive in Cox A16, and 25 patients(17.1%) were positive in both of them.The treatment outcomes showed that 135 patients(92.5%) were cured, 5 patients(3.4%) were improved, 6 patients(4.1%) were dead.

Conclusions

The main symptoms of severe HFMD are fever, skin rash, weakness, limb shaking and sleepiness. The pathogenic examination is helpful to the diagnosis of HFMD. Early detection and intervention are the key point of treatment of severe HFMD.

Key words: hand foot and mouth disease, severe, neurogenic pulmonary edema

[1]	Gilbert GL, Diekson KE, Waters MJ, et al. Outbreaks of enterovirus 71 infection in Victoria，Australia，with a high incidence of neurologic in－volvement[J]. Pediatr Infect Dis J，1988，7:484.
[2]	Shah VA, Chong CY, ChanKP, et al. Clinical characteristics of an out－break of hand，foot and mouth disease in Singapore[J]. Ann Acad Med Singapore，2003，32:381.
[3]	Du CQ, Wu Q, Wang MF, et al.Etiological study and clinical treatment in children with hand foot and mouth disease[J/CD]．Chin J Obstet Gynecol Pediatr：Electron ed, 2012，8(1):60-63.
[4]	Huang RW, Wu XL, Yang RY.Analysis of death cases with hand foot and mouth disease[J/CD]．Chin J Obstet Gynecol Pediatr：Electron Ed，2011，(4):318-320.
[5]	He SJ, Chen D, Zheng XQ, et al.Three cases of enterovirus 71 infection with pulmonary edema or pulmonary hemorrhage as the early clinical manifestation[J]．Chin J Pediatr，2008，46:513-516.

[1]	Ting Lu, Qingmin Fan, Jie Wang, Xiaojing Wan, Chunfang Xu, Fenglin Dong. Ultrasound-guided percutaneous catheter drainage for severe acute pancreatitis: efficacy and application timing[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(05): 511-516.
[2]	Lie Zhang, Yihe Yan, Jieyu Du. Predictive efficacy of secretory leukocyte protease inhibitor in severe pneumonia patients with non-invasive ventilation[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2024, 17(04): 301-306.
[3]	Juan Gao, Feng Zheng, Qing Zhang, Linna Zhu, Xian Wang. Comparative study of three common clinical indexes in fluid management of patients with severe pneumonia[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2024, 17(03): 204-210.
[4]	Baoping Xu, Huaiwen Peng, Huaibin Yu, Xiaotao Wang. A case of diabetic ketoacidosis with hepatic portal vein gas secondary to corona virus disease 2019[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2024, 18(04): 250-255.
[5]	Bo Li, Pengbo Jia, Dong Li, Xiaoqing Li. Effect of ERCP and LCBDE on acute severe cholangitis secondary to choledocholithiasis[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(01): 60-63.
[6]	Junqiang Dang, Yanling Yang, Qingqiang Wang, Lin Shang, Lei Zhu, Hongjun Xiang. Analysis of curative effect of active percutaneous puncture drainage in the treatment of severe acute pancreatitis complicated with acute necrotic accumulation[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 671-674.
[7]	Fanfan Shi, Xiaoqi Wu, Fei Luo, Yuhua Zhao, Chengmin Zhang, Qing Fang. Application of individualized sleep pad in halo-pelvic traction for severe rigid spinal deformity[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2024, 10(05): 308-314.
[8]	Ruhai Wang, Shen Wang, Min Zhang, Chun Li, Chao Han, Qiang Yu, Haicheng Hu, Xizhen Li. Analysis of influencing factors of short-term mortality risk in patients with severe traumatic brain injury after decompressive craniectomy[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(05): 285-291.
[9]	Shen Wang, Ruhai Wang, Chun Li, Zhen Yang, Feilin Sun. Risk factors analysis and prediction model construction of prolonged length of stay in patients with moderate and severe traumatic brain injury[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(03): 146-153.
[10]	Li Cong, Lin Ma, Xu Chen, Wenwen Li, Liangliang Zhang, Huating Zhou. MCTSI and detection of serum inflammatory factors in the prediction of pancreatic infection and prognosis evaluation of severe acute pancreatitis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(05): 432-436.
[11]	Yanqiu Song, Guiyan Qi, Shuangshuang Yang, Ping Zhou. Analysis of gut microbiota characteristics in severe acute pancreatitis and evaluation of clinical value of early enteral nutrition combined with probiotics treatment[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(05): 442-447.
[12]	Xiaozhen Jiang, Xiuxian Chen, Zongwei Chen. Analysis and treatment of extremely severe hypertriglyceridemia after pegaspargase chemotherapy[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(03): 184-186.
[13]	Shuqin Hu, Hongyan Xu, Dan Cao, Yayan Ding. Application of cloud platform video nursing in children with severe asthma and its influence on[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(04): 218-223.
[14]	Yibin Lu, Mengdie Li, Ming Xu. Effect of the cycle teaching of planning， execution， check and action on the training of severe ultrasound-guided hemodynamic evaluation for internal medicine residents[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(04): 224-228.
[15]	Huanliang Liu, Huijuan Cui, Hui Cao, Yuan Fu. The predictive value of shear rate at carotid stenosis for cerebral infarction in patients with hyperhomocysteinemia[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(04): 317-322.

Viewed

Full text

Abstract

Please choose a citation manager

Content to export