Clinical Significance of Nuchal Translucency Thickness by Color Doppler Ultrasound During 11-13+ 6 Gestational Weeks

doi:10.3877/cma.j.issn.1673-5250.2013.01.011

Objective

To study the clinical significance of increment of nuchal translucency thickness (NT) at 11-13^{+ 6} gestational weeks, and provide information for genetic counseling.

Methods

Increment NT of 68 pregnant women collected by prenatal ultrasonic B in the Huibei Maternal and Child Health Hospital from March 2008 to June 2011, 47 of which with increment of NT were suggested to perform amniocentesis chromosomal karyotypes analysis were under followed-up. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Hubei Maternal and Child Health Hospital. Informed consent was obtained from all participates.

Results

The karyotype was abnormal in 14.89% (7/47) of the cases and normal in 85.11%. In cases with normal karyotype, 15.00% (6/40) presented structural abnormalities, 33.33% (2/6) of which consisted of heart defects. There had significant difference of abnormal rate by prenatal ultrasound between normal karyotype baby with increased NT (15.00%, 6/40) and normal NT baby (2.13%, 40/1875).

Conclusions

In cases with increased NT thickness, the frequency of aneuploid and fetal malformations, especially heart defects raised. There is a large group of increased NT with chromosomally normal fetuses that eventually develop into healthy neonates.

Key words: ultrasound, nuchal translucency, chromosomal aberration, congenital malformation, counseling

[1]	Nicolaidcs KH, Azar G, Byrne D, et al. Fetal nuchal translucency: Ultrasound screening for chromosomal defects in the first trimester of pregnancy[J]. BMJ, 1992, 304:867-869.
[2]	Song GN, Liang MY, Wei YQ, et al. The relationship between increment of nuchalsknfold thickness and chromosomally abnormal fetuses[J]. Chin J Clin Obstet Gynecol, 2011, 12(4):265-267.
[3]	Tsai MS, Huang YY, Hwa KY, et al. Combined measurement of fetal nuchal translucency, maternal serum free bata-hCG, and pregnancy-associated plasma protein A for first-trimester Down's syndrome screening[J]. J Formos Med Assoc, 2001, 100(5):319-325.
[4]	Souka AP, Von Kaisenberg CS, Hyett JA, et al. Increased nuchal translucency with normal karyotype[J]. Am J Obstet Gynecol, 2005, 192(4):1005-1021.
[5]	Pandya PP, Snijders RJ, Johnson S, et al. Natural history of trisomy 21 fetuses with increased nuchal translucency thickness[J]. Ultrasound Obstet Gynecol, 1995, 5(6):381-383.
[6]	Brameld KJ, Dickinson JE, O'Leary P, et al. First trimester predictors of adverse pregnancy outcomes[J]. Aust N Z J Obstet Gynaecol, 2008, 48 (6):529-535.
[7]	Saldanha FA, Brizot Mde L, Moraes EA, et al. Increased fetal nuchal translucency thickness and normal karyotype: Prenatal and postnatal follow-up[J]. Rev Assoc Med Bras, 2009, 55(5):575-580.
[8]	Alfirevic Z. DISQ 8: Management of patients with an increased first trimester Down's syndrome screening risk and normal fetal karyotype[J]. Ultrasound Obstet Gynecol, 2008, 31(2):232.
[9]	Caughey A, Kuppernann M, Norton M, et al. Nuchal translucency and first trimester biochemical markers for Down's syndrome screening: A cost-effectiveness analysis[J]. Am J Obstet Gynecol, 2002, 187:1239-1245.

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