Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2013, Vol. 09 ›› Issue (01): 48 -50. doi: 10.3877/cma.j.issn.1673-5250.2013.01.011

Special Issue:

Original Article

Clinical Significance of Nuchal Translucency Thickness by Color Doppler Ultrasound During 11-13+ 6 Gestational Weeks

Yan-yi YAO1(), Jie-ping SONG1, Shu-qin XU1, Bo WAN1, Huai GUO1   

  1. 1. Department of Birth Health and Heredity, Hubei Maternal and Child Health Hospital, Wuhan 430070, Hubei Province, China
  • Received:2012-10-11 Revised:2013-01-08 Published:2013-02-01
  • Corresponding author: Yan-yi YAO
  • About author:
    Corresponding author: YAO Yan-yi, Email:
Objective

To study the clinical significance of increment of nuchal translucency thickness (NT) at 11-13+ 6 gestational weeks, and provide information for genetic counseling.

Methods

Increment NT of 68 pregnant women collected by prenatal ultrasonic B in the Huibei Maternal and Child Health Hospital from March 2008 to June 2011, 47 of which with increment of NT were suggested to perform amniocentesis chromosomal karyotypes analysis were under followed-up. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Hubei Maternal and Child Health Hospital. Informed consent was obtained from all participates.

Results

The karyotype was abnormal in 14.89% (7/47) of the cases and normal in 85.11%. In cases with normal karyotype, 15.00% (6/40) presented structural abnormalities, 33.33% (2/6) of which consisted of heart defects. There had significant difference of abnormal rate by prenatal ultrasound between normal karyotype baby with increased NT (15.00%, 6/40) and normal NT baby (2.13%, 40/1875).

Conclusions

In cases with increased NT thickness, the frequency of aneuploid and fetal malformations, especially heart defects raised. There is a large group of increased NT with chromosomally normal fetuses that eventually develop into healthy neonates.

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