Application of Artificial Bronchial Provocation Test in the Diagnosis of Chronic Cough in Children

doi:10.3877/cma.j.issn.1673-5250.2012.04.021

Objective

To evaluation the safety and application value of artificial bronchial provocation tests(BPT)with methacholine(MCH) in children which judged by lung auscultation(AHR).

Methods

From January 2010 to August 2010, 700 children with chronic cough were included in the study, and divided into ≤3 years old group(n=534)and >3 years old group(n=166). They were all accepted artificial BPT with MCH.Heart rate, breathing, oxygen saturation, cough and pulmonary wheeze were monitored in the process of test. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of the Central Hospital of Mianyang. Informed concent was obtained from each parents.

Results

The total positive rate of BPT was 80%(560/700). No significant difference was found between ≤3 years old group and >3 years old group(P>0.05). There was no significant difference in vital sign changes between before and after BPT in both groups(P>0.05). All patients had no serious adverse reaction.

Conclusions

Artificial BPT with MCH is a reliable and safe method for children with chronic cough, and plays an important role in the etiologic diagnosis.This method is suitable for primary hospitals without baby tidal breathing pulmonary function equipment.

Key words: artificial bronchial provocation test, methacholine, chronic cough, children

表1 两组患儿BPT阳性率比较[n(%)]

Table 1 Comparison of BPT positive rate between two groups[n(%)]

组别	N	BPT呈阳性				BPT呈阴性
组别	N	极轻度AHR	轻度AHR	中度AHR	重度AHR	BPT呈阴性
≤3岁组	534	60(8.57)	34(4.86)	174(24.86)	154(22.00)	112(16.00)
>3岁组	166	40(5.71)	9(1.29)	38 (5.43)	51 (7.29)	28 (4.00)
P	?	>0.05	－	?	?	?

表1 两组患儿BPT阳性率比较[n(%)]

Table 1 Comparison of BPT positive rate between two groups[n(%)]

组别	N	BPT呈阳性				BPT呈阴性
组别	N	极轻度AHR	轻度AHR	中度AHR	重度AHR	BPT呈阴性
≤3岁组	534	60(8.57)	34(4.86)	174(24.86)	154(22.00)	112(16.00)
>3岁组	166	40(5.71)	9(1.29)	38 (5.43)	51 (7.29)	28 (4.00)
P	?	>0.05	－	?	?	?

表2 BPT前、后患儿生命体征变化比较(±s)

Table 2 Comparison of vital sign changes between before and after BPT(±s)

项目	呼吸	心率	血氧饱和度
BPT前	30.25±7.40	105.65±15.50	0.96±0.0007
BPT后	30.90±7.89	106.32±18.36	0.95±0.0006
P	>0.05	>0.05	>0.05

表2 BPT前、后患儿生命体征变化比较(±s)

Table 2 Comparison of vital sign changes between before and after BPT(±s)

项目	呼吸	心率	血氧饱和度
BPT前	30.25±7.40	105.65±15.50	0.96±0.0007
BPT后	30.90±7.89	106.32±18.36	0.95±0.0006
P	>0.05	>0.05	>0.05

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