Application of Artificial Bronchial Provocation Test in the Diagnosis of Chronic Cough in Children

doi:10.3877/cma.j.issn.1673-5250.2012.04.021

Objective

To evaluation the safety and application value of artificial bronchial provocation tests(BPT)with methacholine(MCH) in children which judged by lung auscultation(AHR).

Methods

From January 2010 to August 2010, 700 children with chronic cough were included in the study, and divided into ≤3 years old group(n=534)and >3 years old group(n=166). They were all accepted artificial BPT with MCH.Heart rate, breathing, oxygen saturation, cough and pulmonary wheeze were monitored in the process of test. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of the Central Hospital of Mianyang. Informed concent was obtained from each parents.

Results

The total positive rate of BPT was 80%(560/700). No significant difference was found between ≤3 years old group and >3 years old group(P>0.05). There was no significant difference in vital sign changes between before and after BPT in both groups(P>0.05). All patients had no serious adverse reaction.

Conclusions

Artificial BPT with MCH is a reliable and safe method for children with chronic cough, and plays an important role in the etiologic diagnosis.This method is suitable for primary hospitals without baby tidal breathing pulmonary function equipment.

Key words: artificial bronchial provocation test, methacholine, chronic cough, children

表1 两组患儿BPT阳性率比较[n(%)]

Table 1 Comparison of BPT positive rate between two groups[n(%)]

组别	N	BPT呈阳性				BPT呈阴性
组别	N	极轻度AHR	轻度AHR	中度AHR	重度AHR	BPT呈阴性
≤3岁组	534	60(8.57)	34(4.86)	174(24.86)	154(22.00)	112(16.00)
>3岁组	166	40(5.71)	9(1.29)	38 (5.43)	51 (7.29)	28 (4.00)
P	?	>0.05	－	?	?	?

表1 两组患儿BPT阳性率比较[n(%)]

Table 1 Comparison of BPT positive rate between two groups[n(%)]

组别	N	BPT呈阳性				BPT呈阴性
组别	N	极轻度AHR	轻度AHR	中度AHR	重度AHR	BPT呈阴性
≤3岁组	534	60(8.57)	34(4.86)	174(24.86)	154(22.00)	112(16.00)
>3岁组	166	40(5.71)	9(1.29)	38 (5.43)	51 (7.29)	28 (4.00)
P	?	>0.05	－	?	?	?

表2 BPT前、后患儿生命体征变化比较(±s)

Table 2 Comparison of vital sign changes between before and after BPT(±s)

项目	呼吸	心率	血氧饱和度
BPT前	30.25±7.40	105.65±15.50	0.96±0.0007
BPT后	30.90±7.89	106.32±18.36	0.95±0.0006
P	>0.05	>0.05	>0.05

表2 BPT前、后患儿生命体征变化比较(±s)

Table 2 Comparison of vital sign changes between before and after BPT(±s)

项目	呼吸	心率	血氧饱和度
BPT前	30.25±7.40	105.65±15.50	0.96±0.0007
BPT后	30.90±7.89	106.32±18.36	0.95±0.0006
P	>0.05	>0.05	>0.05

[1]	Cockcroft DW, Davis BE, Smycniuk AJ, et al.Development of a methacholine challenge method to minimize methacholine waste[J].Chest, 2003, 124(4):1522-1525.
[2]	Bez C, Sach G, Jarisch A, et al.Safety and tolerability of methacholine challenge in infants with recurrent wheeze[J].Asthma, 2003, 40(7):795-802.
[3]	Yuan HX, Huang Y, Chen KH, et al.Application of bronchial provocation test to diagnose chronic cough in infants[J]. Acta Acad Med Militaris Tertiae, 2007, 29(20):2002-2004.

[1]	Hongyu Tao, Jingjing Ye, Jin Yu, Xiuzhen Yang, Jingjing Qian, Bin Xu, Weize Xu, Qiang Shu. Value of contrast transthoracic echocardiography in assessing right-to-left shunt-related diseases in children[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(10): 959-965.
[2]	Fang Liu, Chunyuan Huang, Fenglin Wang, Yimei Ma, Tao Tang, Wenjia Hou, Lei Liu. Summary of the best evidence on non-pharmacological management for procedural pain of burn wounds in children[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(02): 159-164.
[3]	Baoying Zheng, Xiaolan Huang, Nan Jia, Chunmei Zhu. Early warning indicators of children with refractory mycoplasma pneumoniae pneumonia[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2024, 18(04): 215-221.
[4]	Xiaoli Yang, Wanfu Li, Zhu Ma, Lan Ma, Yi Zheng, Xiaoli Fu, Jing Wang. Application effect of one-step forceps needle method in laparoscopic high ligation of hernia sac in children[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 535-538.
[5]	Hebei Ding, Xun Wang, Weiguo Chen. Comparison of application of sevoflurane inhalation anesthesia and propofol intravenous anesthesia in pediatric indirect inguinal hernia surgery[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(05): 570-574.
[6]	Jixiao Zeng, Xiaogang Xu, Xinxing Wang, Fei Liu, Menglong Lan, Boyuan Tao, Zijian Liang, Zhihua Ye, Yuanyuan Luo. Da Vinci robotic-assisted Swenson-like pull through for Hirschsprung disease[J]. Chinese Journal of Laparoscopic Surgery(Electronic Edition), 2024, 17(04): 239-243.
[7]	Chinese Society of Organ Transplantation of Chinese Medical Association, Surgery Group of Chinese Society of Surgery of Chinese Medical Association, Transplantation Group of Chinese Society of Surgery of Chinese Medical Association, South China Alliance of Split Liver Transplantation. Chinese Clinical Practice Guidelines on Split Liver Transplantation in Children[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 593-601.
[8]	Jiachen Zhang, Hongxin Song. The correlation between the changes of spherical equivalent and myopia progression in children with refractive error[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(04): 217-222.
[9]	Chen Zhang, Ming Qin, Juan Dong, Yulong Chen. Diagnostic value of ultrasound in ischemic changes of intestinal volvulus in children[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(06): 565-568.
[10]	Jiuhong Wang, Li Ding, Li Liang. Diagnostic value and experience of abdominal color ultrasound combined with high-frequency color ultrasound in children with intussusception[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(03): 226-228.
[11]	Xiaoyu Wang, Qunying Guo, Yameng Niu, Chengsong Zhao. Practice of promoting equal access to pediatric medical care in public children's hospitals[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(04): 383-387.
[12]	Wenjuan Li, Fan Yang, Anqi Zhang, Xiaoqing Yin, Yuanyuan Li, Fangfan Zheng. Correlation between the imaging manifestation of spina bifida occulta and clinical symptoms and curative effect in children with nocturnal enuresis[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2024, 12(04): 356-361.
[13]	Nuo Yan, Wei Deng, Yingxia Zhang, Danyang He, Ning Fan. Diagnostic value of urinary system ultrasound combined with procalcitonin for high-grade vesicoureteral reflux in children[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(03): 149-154.
[14]	Xiaosheng Chen, Jia He, Fang Liu, Rui Wu, Haitao Yang, Xiaohan Fan. Pacemaker implantation in a child with a 31-second cardiac arrest induced by tilt table test: a case report and literature review[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 488-494.
[15]	Yali Cao, Yumeng Gao, Yingqian Zhang, Bo Li, Junbao Du, Hongfang Jin. Clinical progress of sitting intolerance in children[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 510-515.

Viewed

Full text

Abstract

Please choose a citation manager

Content to export