Analysis Infection Condition and Curative Effect of Vulvovaginal Candidiasis and Bacterial Vaginosis

doi:10.3877/cma.j.issn.1673-5250.2012.02.024

Objective

To study the infection condition and curative effect of woman with vulvovaginal candidiasis(VVC) or bacterial vaginosis(BV).

Methods

From June 2009 to December 2010, 1280 non-pregnant outpatients were enrolled in this study.Questionnaire investigation, medical history, gynecological checkup and lab results were collected. Incidence rate, influencing factors and curative effects were analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Taian Disabled Soldier Hospital of Shandong. Informed consent was obtained from each patient.

Results

The incidence rate of VVC and BV were 7.5% and 9.69%, respectively.Vaginal lactobacillus had higher detection rate in VVC group than that in BV group (P<0.01). Gynecological inflammation, contraceptive methods, individual habits, repeated abortion and so on , had the influence of different levels on VVC group and BV group. The key factor of affecting curative effect was not accept the standard treatment. There had significant difference between subgroup A and B in cure rate after treatment (P<0.05).

Conclusions

VVC and BV are associated with dysbacteriosis in vagina. To strengthen health education and carry on the standard treatment are the effective action for reducing incidence of VVC and BV.

Key words: vulvovaginal candidiasis, bacterial vaginosis, influencing factor, curative effect, health education

表1 生殖道健康状况[n(%)]

Table 1 Health condition of genital tract [n(%)]

组别	n	乳酸杆菌检出率	pH值(±s)
VVC组	96	51(53.13)	4.10±0.35
BV组	124	23(18.54)	5.10±0.32

表1 生殖道健康状况[n(%)]

Table 1 Health condition of genital tract [n(%)]

组别	n	乳酸杆菌检出率	pH值(±s)
VVC组	96	51(53.13)	4.10±0.35
BV组	124	23(18.54)	5.10±0.32

表2 VVC组与BV组影响因素比较(n)

Table 2 Comparison of influencing factors between two groups(n)

相关因素			n	VVC	BV
妇产科疾病史			?	?	?
?	一年内流产(1～2次)		?	?	?
?	?	＋	312	32	31
?	?	－	968	64	93
?	?	P	?	<0.05	<0.05
?	慢性宫颈炎		?	?	?
?	?	＋	298	21	33
?	?	－	982	75	91
?	?	P	?	>0.05	>0.05
避孕方式			?	?	?
?	避孕套		332	20	25
?	其他		948	76	99
?	P		?	>0.05	<0.05
生活习惯			?	?	?
?	阴道冲洗(≥2次/周)		70	11	15
?	仅清洗外阴(≥3次/周)		1210	85	109
?	P		?	<0.05	<0.05
经期性生活			?	?	?
?	＋		47	8	13
?	－		1233	88	111
?	P		?	<0.05	<0.05

表2 VVC组与BV组影响因素比较(n)

Table 2 Comparison of influencing factors between two groups(n)

相关因素			n	VVC	BV
妇产科疾病史			?	?	?
?	一年内流产(1～2次)		?	?	?
?	?	＋	312	32	31
?	?	－	968	64	93
?	?	P	?	<0.05	<0.05
?	慢性宫颈炎		?	?	?
?	?	＋	298	21	33
?	?	－	982	75	91
?	?	P	?	>0.05	>0.05
避孕方式			?	?	?
?	避孕套		332	20	25
?	其他		948	76	99
?	P		?	>0.05	<0.05
生活习惯			?	?	?
?	阴道冲洗(≥2次/周)		70	11	15
?	仅清洗外阴(≥3次/周)		1210	85	109
?	P		?	<0.05	<0.05
经期性生活			?	?	?
?	＋		47	8	13
?	－		1233	88	111
?	P		?	<0.05	<0.05

表3 VVC A，B亚组治疗效果比较(n)

Table 3 Comparison of curative effect between VVC subgroup A and B (n)

组别	n	1～2周复诊			4～5周复诊
组别	n	痊愈	好转	无效	痊愈	好转	无效	复发率(%)
A亚组	66	63	3	0	58	5	3	7.94
B亚组	30	21	7	2	16	11	3	23.81
P	?	<0.05	－	－	<0.05	－	－	?

表3 VVC A，B亚组治疗效果比较(n)

Table 3 Comparison of curative effect between VVC subgroup A and B (n)

组别	n	1～2周复诊			4～5周复诊
组别	n	痊愈	好转	无效	痊愈	好转	无效	复发率(%)
A亚组	66	63	3	0	58	5	3	7.94
B亚组	30	21	7	2	16	11	3	23.81
P	?	<0.05	－	－	<0.05	－	－	?

表4 BV A，B亚组治疗效果比较

Table 4 Comparison of curative effect between BV subgroup A and B(n)

组别	n	1～2周复诊			4～5周复诊
组别	n	痊愈	好转	无效	痊愈	好转	无效	复发(%)
A亚组	84	78	5	1	71	10	3	8.97
B亚组	40	29	7	4	22	13	5	24.14
P	?	<0.05	－	－	<0.05	－	－	?

表4 BV A，B亚组治疗效果比较

Table 4 Comparison of curative effect between BV subgroup A and B(n)

组别	n	1～2周复诊			4～5周复诊
组别	n	痊愈	好转	无效	痊愈	好转	无效	复发(%)
A亚组	84	78	5	1	71	10	3	8.97
B亚组	40	29	7	4	22	13	5	24.14
P	?	<0.05	－	－	<0.05	－	－	?

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