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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2012, Vol. 08 ›› Issue (01): 47 -50. doi: 10.3877/cma.j.issn.1673-5250.2012.01.012

Special Issue: Highlights； ；

Original Article

Analysis of Distribution and Antibacterial Resistance of Positive Results of Blood Cultures in Newborn With Septicemia in Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province

Cheng-peng BIAN1, Yao YANG1()   

  1. 1. Department of Pediatrics, First People's Hospital in Liangshan, Xichang 615000, Sichuan Province, China
  • Received:2011-08-10 Revised:2011-12-20 Published:2012-02-01
  • Corresponding author: Yao YANG
  • About author:
    Corresponding author: YANG Yao, Email:
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Objective

To investigate distribution and antibacterial resistance of pathogens causing neonatal septicemia in Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province.

Methods

A total of 254 blood samples of newborn with positive results of blood cultures from May 2005 to October 2010 were identified and their drug-susceptibility tests were done. The study protocal was approved by the Ethical Review Board of Investigation in human being of First People's Hospital in Liangshan.

Results

Among 254 strains, 237 strains (93.3%) were Gram-positive (G+ ) strains and 17 strains (6.7%) were Gram-negative (G-) strains. Among the G+ strains, coagulase negative Staphylococcus (CNS) accounted for 82.3%(195/237) and took the overall isolating rate of 76.8%(195/254). Escherichia Coli took the major part in the G- strains, which accounted for 5.5%(14/254) of the overall isolating rate. The top four pathogens detected from this study were Staphylococcus Epidermidis, Staphylococcus Haemolyticus, Staphylococcus Hominis and Escherichia Coli. Drug sensitivity results showed that G+ strains including Staphylococcus Epidermidis, Staphylococcus Haemolyticus and Staphylococcus Hominis had the highest resistance rate to penicillin, then, erythromycin, ampicillin, cephazoline, amoxicillin/clavulanic acid and Sulfamathoxazole and trimethoprim(SMZ-TMP), while all of them were sensitive to vancomycin and rifampin. Escherichia coli had relatively high resistance rate to ampicillin and cefotaxime, then cephazoline, gentamicin and chloromycin, but very sensitive to imipenem.

Conclusions

G+ strains are the mojor pathogens causing neonatal septicemia in Xichang city, Liangsha Yi Autonomous Prefecture, Sichuan Province. Among G+ strains, CNS takes the first place, among G strains Escherichia coli is at the first. The phenomenon of antibacterial resistance is quite common and severe.

Key words: neonate, septicemia, blood culture, pathogenic bacterium, drug resistance
表1 254例新生儿血培养病原菌分布(%)
Table 1 Distribution of pathogenic bacterium in blood culture among 254 neonates(%)
菌种 n(菌株数) 构成比
G＋菌 237 93.3
? CNS 195 76.8
? ? 表皮葡萄球菌 111 43.7
? ? 溶血葡萄球菌 47 18.5
? ? 人葡萄球菌 18 7.1
? ? 其他葡萄球菌 19 7.5
? 金黄色葡萄球菌 8 3.1
? 链球菌属 5 2.0
? ? 溶血性链球菌 2 0.8
? ? 草绿色链球菌属 3 1.2
? 肠球菌属 20 7.8
? ? 粪肠球菌 12 4.7
? ? 屎肠球菌 8 3.1
? 棒状杆菌 6 2.4
? 微球菌属 3 1.2
G－菌 17 6.7
? 大肠埃希菌 14 5.5
? 琼氏不动杆菌 1 0.4
? 他莫拉菌 2 0.8
合计 254 100.0
表2 检出率最高的4种主要病原菌对常用抗菌药物的耐药性比较[n(%)]
Table 2 Comparison of antibacterial resistance among S．Epidermidis，S.Hemolyticus，S.Huminis and E. coli [n(%)]
抗菌药物 表皮葡萄球菌(n＝111) 溶血葡萄球菌(n＝47) 人葡萄球菌(n＝18) 大肠埃希菌(n＝14)
青霉素 111(100.0) 47(100.0) 13(72.2) －
氨苄西林 108 (97.3) 47(100.0) 14(77.8) 12(85.7)
头孢唑啉 96 (86.5) 41 (87.2) 13(72.2) 8(57.1)
红霉素 91 (82.0) 47(100.0) 14(77.8) －
阿莫西林/克拉维酸 96 (86.5) 42 (89.4) 12(66.7) 4(28.6)
复方甲基异口恶唑 76 (68.5) 33 (70.2) 11(61.1) －
庆大霉素 52 (46.8) 43 (91.5) 4(22.2) 7(50.0)
环丙沙星 53 (47.7) 36 (76.6) 3(16.7) 8(57.1)
左氧氟沙星 50 (45.1) 33 (70.2) 1 (5.6) 2(14.3)
克林霉素 25 (22.5) 22 (46.8) 5(27.8) －
氯霉素 21 (18.9) 11 (23.4) 4(22.2) －
码啉恶酮 6(5.4) 5(1.1) 10(55.6) －
奎奴普丁/达福普丁 6(5.4) 0(0.0) 5(27.8) －
利福平 0(0.0) 0(0.0) 0 (0.0) －
万古霉素 0(0.0) 0(0.0) 0 (0.0) －
头孢噻肟 － － － 11(78.6)
亚胺培南 － － － 1 (7.1)
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