Study of Serum Hormone Levels on Empty Sella Syndrome Female Patient

doi:10.3877/cma.j.issn.1673-5250.2012.01.005

Objective

Study the serum hormone levels between empty sella syndrome (ESS) female patients and healthy volunteers.

Methods

From February 2007 to April 2011, a total of 30 cases of ESS female patients and 30 healthy volunteers admitted in the Longgang Central Hospital were chosed in ESS group(n=30) and control group(n=30). The serum follicle-stimulating hormone (FSH), luteinizing hormone(LH), prolactin (PRL), progesterone (P), testosterone(T)and estradiol(E₂) were examined in both groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Longgang Central Hospital of Shenzhen. Informed consent was obtained from each patients. There had no significant differences between two groups among gender, age and etc..(P>0.05).

Results

There had significant difference of serum PRL between two groups(P<0.05). There had no significant differences among other five kinds of serum hormone(FSH, LH, P, T, and E₂) levels between two groups (P>0.05).

Conclusions

ESS female patients have hypopituitarism and hyperprolactinemia.

Key words: empty sella syndrome, hormone, magnetic resonance imaging, female

表1 两组血清激素水平测量结果比较(±s)

Table 1 Comparison of serum hormone levels between two groups (±s)

组别	FSH(mIU/mL)	LH(mIU/mL)	PRL(IU/mL)	P(ng/mL)	T(ng/mL)	E₂(pg/mL)
ESS组	8.822±1.090	15.500±2.689	2435.700±899.407	3.023±1.210	0.625±0.159	213.686±131.689
对照组	8.653±1.479	16.233±2.359	390.967±110.240	2.867±1.347	0.623±0.158	214.205±131.889
t	－0.505	1.123	－12.360	－0.474	－0.057	0.015
P	0.616	0.266	0.000	0.637	0.955	0.988

表1 两组血清激素水平测量结果比较(±s)

Table 1 Comparison of serum hormone levels between two groups (±s)

组别	FSH(mIU/mL)	LH(mIU/mL)	PRL(IU/mL)	P(ng/mL)	T(ng/mL)	E₂(pg/mL)
ESS组	8.822±1.090	15.500±2.689	2435.700±899.407	3.023±1.210	0.625±0.159	213.686±131.689
对照组	8.653±1.479	16.233±2.359	390.967±110.240	2.867±1.347	0.623±0.158	214.205±131.889
t	－0.505	1.123	－12.360	－0.474	－0.057	0.015
P	0.616	0.266	0.000	0.637	0.955	0.988

表2 两组血清激素水平的95%可信区间

Table 2 Comparison of 95%CI of serum hormone levels between two groups

组别	FSH(mIU/mL)	LH(mIU/mL)	PRL(IU/mL)	P (ng/mL)	T (ng/mL)	E₂(pg/mL)
对照组	－0.840～0.502	－0.574～2.041	－2375.890～－1713.570	－0.818～0.505	－0.844～0.079	－67.590～68.633
ESS组	－0.842～0.503	－0.575～2.041	－2382.660～－1706.800	－0.819～0.506	－0.844～0.080	－67.600～68.633

表2 两组血清激素水平的95%可信区间

Table 2 Comparison of 95%CI of serum hormone levels between two groups

组别	FSH(mIU/mL)	LH(mIU/mL)	PRL(IU/mL)	P (ng/mL)	T (ng/mL)	E₂(pg/mL)
对照组	－0.840～0.502	－0.574～2.041	－2375.890～－1713.570	－0.818～0.505	－0.844～0.079	－67.590～68.633
ESS组	－0.842～0.503	－0.575～2.041	－2382.660～－1706.800	－0.819～0.506	－0.844～0.080	－67.600～68.633

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