To observe the best approach of combined therapy of the advanced cervical cancer.

From June 1990 to June 2010, 126 women with advanced cervical carcinoma were divided into four groups according to combined therapy regimen. Group A (n= 46) underwent ⁶⁰Co external beam radiotherapy + intracavitary radiotherapy. Group B (n=26) underwent interventional uterine arterial chemoembolization. Group C (n=19) underwent intracavitary radiotherapy + ⁶⁰Co external beam radiotherapy with accelerator linear after interventional uterine arterial chemoembolization. Group D (n= 35) underwent radiotherapy by neutron knife and accelerator linear. The procedure of this study was consistent with ethical standard established by the committee of investigation in human beings of Affiliated Yue Bei People's Hospital of Shantou University Medical College. Informed consent was obtained from all participates. There had no significant differences of ages, degrees of cervical carcinoma, classifications, clinical stages between two groups. The therapeutic efficacy among four groups were conducted by retrospective analysis.

Therapeutic efficacy (haltting colporrhagia, tumoral minification and three- and five- years survival rates) in group C were significance better than those in other three groups (P< 0.05). Clinical death rate in group C had statistically significant difference than those in other three groups (P<0.05).

It is optimization that intracavitary radiotherapy or neutron knife and electron beam radiotherapy with accelerator linear after interventional uterine arterial chemoembolization to treat advanced cervical carcinoma.