Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2011, Vol. 07 ›› Issue (04): 362 -365. doi: 10.3877/cma.j.issn.1673-5250.2011.04.023

Review

Research Progress of Indoleamine 2, 3-Dioxygenase on Hematopoietic Stem Cell Transplantation

Qi-xiang YE   

  1. Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, China
  • Published:2011-08-01
  • Supported by:
    * Project No. 30872383, supported by the National Natural Science Foundation of China; project No.20090171110064, supported by the Doctor Degree Foundation of Technology Ministry of China.

Indoleamine 2, 3-dioxygenase (IDO)is found could induce T cells immunity tolerance by inducing tryptophan decompose, regulating dendritic cells and T cells and relevant molecular mechanism to prevent graft versus host disease(GVHD)and improve the survive rate of graft. It has became a therapeutic target to improve the success rate of hematopoietic stem cell transplantation(HSCT).

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