Research the Effect of Antirelapse Mycobacterium Phlei Injection on Cough Variant Asthma in Children

doi:10.3877/cma.j.issn.1673-5250.2011.02.012

Objective

To observe the effects of Mycobacterium phlei injection on antirelapse in cough variant asthma (CVA) and mechanism investigation.

Methods

From January 2008 to October 2010, 49 children with cough variant asthma were randomly divided into case group(n=25) and control group(n=24). Ages, sexes, course of disease between two groups had no significant differences(P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhen Children's Hospital. Informed consent was obtained from the parents of each participating child. All children with cough variant asthma were all treated with montelukast. Mycobacterium phlei injection was given to case group(once a week for 12 weeks). The relapse rate during the treatment and within one year after course of treatment. A dynamic detection for absolute value of eosinophile count, total immunoglobubin(Ig) E, and helper T lymphocyte(Th) subsets was done in both groups.

Results

The relapse rate in case group was lower than that of control group (t=3.98, 3.63; P<0.01). The absolute value of eosinophile count, total immunoglobubin E, the percentage of Th1 and Th2 and the ratio of Th1 and Th2(Th1/Th2) between two groups before treatment had no significant differences(P>0.05). After treatment by Mycobacterium phlei injection, the Th1/Th2 in case group were significantly higher than those of control group (t=2.81, 2.16; P<0.05), meanwhile the absolute value of eosinophile count and total immunoglobubin E in case group were significantly lower than those in control group (t=3.68, 3.41; P<0.01).

Conclusion

Mycobacterium phlei injection is effective for prevention of relapse of cough variant asthma.Its mechanism is related to adjusting Th1/Th2 function balance, lowering the eosinophile and total immunoglobubin E, accelerating the recovery of cough variant asthma immune abnormality and improving the capability of anti-infection.

Key words: cough variant asthma (CVA), relapse, T-lymphocyte, helper-inducer, Mycobacterium phlei, treatment outcome, child

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