Research the Effect of Antirelapse Mycobacterium Phlei Injection on Cough Variant Asthma in Children

doi:10.3877/cma.j.issn.1673-5250.2011.02.012

Objective

To observe the effects of Mycobacterium phlei injection on antirelapse in cough variant asthma (CVA) and mechanism investigation.

Methods

From January 2008 to October 2010, 49 children with cough variant asthma were randomly divided into case group(n=25) and control group(n=24). Ages, sexes, course of disease between two groups had no significant differences(P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhen Children's Hospital. Informed consent was obtained from the parents of each participating child. All children with cough variant asthma were all treated with montelukast. Mycobacterium phlei injection was given to case group(once a week for 12 weeks). The relapse rate during the treatment and within one year after course of treatment. A dynamic detection for absolute value of eosinophile count, total immunoglobubin(Ig) E, and helper T lymphocyte(Th) subsets was done in both groups.

Results

The relapse rate in case group was lower than that of control group (t=3.98, 3.63; P<0.01). The absolute value of eosinophile count, total immunoglobubin E, the percentage of Th1 and Th2 and the ratio of Th1 and Th2(Th1/Th2) between two groups before treatment had no significant differences(P>0.05). After treatment by Mycobacterium phlei injection, the Th1/Th2 in case group were significantly higher than those of control group (t=2.81, 2.16; P<0.05), meanwhile the absolute value of eosinophile count and total immunoglobubin E in case group were significantly lower than those in control group (t=3.68, 3.41; P<0.01).

Conclusion

Mycobacterium phlei injection is effective for prevention of relapse of cough variant asthma.Its mechanism is related to adjusting Th1/Th2 function balance, lowering the eosinophile and total immunoglobubin E, accelerating the recovery of cough variant asthma immune abnormality and improving the capability of anti-infection.

Key words: cough variant asthma (CVA), relapse, T-lymphocyte, helper-inducer, Mycobacterium phlei, treatment outcome, child

	1　Respiratory Study Group of Chinese Academy of Pediatrics. Conventional prevention and treatment of children with bronchial asthma(Practice)[J]．Chin J Pediatr，2004，42(2)：100-103. [中华儿科学会呼吸学组．儿童支气管哮喘防治常规(试行)(2003年修订)[J]．中华儿科杂志，2004，42(2)：100-103.]
	2　Zielen S, Kardos P, Madonini E. Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: A randomized controlled trial[J]．Allergy Clin Immunol，2010，126(5)：942-949.
	3　Bernstein DI, Epstein T, Murphy-Berendts K, et al. Surveillance of systemic reactions to subcutaneous immunotherapy injections: Year 1 outcomes of the ACAAI and AAAAI collaborative study[J]. Ann Allergy Asthma Immunol，2010，104(6)：530-535.
	4　Fumuso EA, Aguilar J, Giguère S，et al. Immune parameters in mares resistant and susceptible to persistent post-breeding endometritis：Effects of immunomodulation[J]．Vet Immunol Immunopathol, 2007，118(1-2)：30-39.
	5　Askambaeva KA, Shafranova NG. Evaluation of individual sensitivity to levamisole in children with asthmatic bronchitis[J]. Sov Med，1990，10：29-31.
	6　Kocabas CN, Sekerel BE, Firat PA, et al.Levamisole: Might it be used in treatment and prevention of atopic diseases [J] ? J Asthma，2004，41(5)：547-551.
	7　Kong YJ，Liu XM，Zhang YM.The influence of UTILIN " S" on the immunologic function of patients with pulmonary tuberculosis[J]．J Harbin Med Univ，2000，34(1)：29-30. [孔英君，刘晓民，张一梅．乌体林斯对肺结核患者免疫功能的影响[J]．哈尔滨医科大学学报，2000，34(1)：29-30.]
	8　Wang YF，Li M，Dong W，et al.Utilins sublingual treatment of children with recurrent respiratory tract infections[J]. Chin J Pediatr，2000，38(3)：179-180. [王运芳，李敏，董巍，等．舌下含服乌体林斯治疗儿童反复呼吸道感染[J]．中华儿科杂志，2000，38(3)：179-180.]
	9　Lin RJ. Clinical and immune effects of Mycobacterium phlei F．U.36 therapy in children with asthma[J]. Chin J New Drugs Clin Remedies，2005，24(5)：382-383. [林荣军．草分枝杆菌F.U.36治疗支气管哮喘的疗效及其免疫学效应[J]．中国新药与临床杂志，2005，24(5)：382-383.]

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