To study the efficacy of three-dimensional conformal radiation therapy(3DCRT) combined with interventional chemotherapy for intermediate and advanced cervical cancer.

From March 2006 to May 2007, 80 women patients with cervical cancer at Ⅱ_B-Ⅲ stage were randomly divided into experimental group(n=40) which received three-dimensional conformal radiation therapy combined with interventional chemotherapy and control group(n=40) which received three-dimensional conformal radiation therapy combined with intravenous chemotherapy. Efficacy and side effects were compared between two groups, and follow-up more than 2 years. Informed consent was obtained from all participates.

Complete remission(CR) rate and 2-year survival rate of experimental group were significantly higher than those of control group (85.0% vs. 77.5%, 87.5% vs. 75.0%) (P<0.05). Side effects of gastrointestinal tract and myelosuppression were less serious than those of control group(P<0.05). There had no significant differences in side effects of urinary system between two groups (P=1.107).

Three-dimensional conformal radiation therapy combined with interventional chemotherapy could improve the clinical efficacy with less side effects. It is an effective treatment for intermediate and advanced cervical cancer.