Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2008, Vol. 04 ›› Issue (05): 456 -459. doi: 10.3877/cma.j.issn.1673-5250.2008.05.112

Original Article

The Clinical Research of the Variation in Serum Electrolyte and Blood Sugar of the Asphyxia Neonates

He JIAN, Rao YANG   

  1. Department of Pediatrics, the First Hospital of Liangshan Yi Autonomous Prefecture, Xichang 615000, China
  • Published:2008-10-01
Objective

To investigate the disease progress of concentration of serum electrolytes and glucose in asphyxiated neonates.

Methods

65 asphyxia neonates who had no intravenous infusion were divided into mild asphyxia group(n=32) and severe asphyxia group(n=33) according to the Apgar scale in the Department of Pediatrics, First Hospital of Liangshan Yi Autonomous Prefecture from January 2006 to December 2006. 30 newborns without asphyxia were as the control group (Informed consent was obtained from all participants). The first peripheral blood samples without any treatment were drew for analysis of the serum electrolytes and blood sugar, which were calculated by Chi-square, student-t test and odds ratio (OR).

Results

Besides the serum potassium, other electrolytes (sodium, chlorine, calcium) in the asphyxia group decreased significantly (P<0.01) in contrast to the control group. Far greater incidence suggested by OR analysis that hyponatremia, low blood chlorine, hypocalcemia and high blood sugar were found in the asphyxia group. The low blood sugar and hyperkalemia were less likely to occur, whereas the asphyxiated group were liable to hyperglycemia in comparison to the control group (P<0.01). There were significant difference in hyponatremia, low blood chlorine, hypocalcemia, and high blood sugar between mild and severe asphyxia subgroup (P<0.01).

Conclusion

Neonatal asphyxia may give rise to serum electrolyte disturbance and changes of blood glucose which are the risk factors of disease progress and prognosis. Timely identification and correction of the internal environment would reduce the multiple organ damages.

1 Jin HZ,Hua DM,Guan XJ.For the School Children.3rd ed. Beijing:People's Medical Publishing House,2003,409-410,516,813,819,1014.[金汉珍,黄德珉,官希吉.实用新生儿学.第3版.北京:人民卫生出版社,2003,409-410, 516,813,819,1014.]
2 Hu YM, Jiang ZF. Zhu Futang practical pediatrics.7th ed. Beijing: People's Medical Publishing House, 2006, 485-488.[胡亚美,江载芳.诸福棠实用儿科学. 第7版 .北京:人民卫生出版社,2006,485-488.]
3 Zhang JY,Wei KL,Xue XD.Newborn of Emergency.Beijing:People's Medical Publishing House,2000,614.[张家雍,魏克伦,薛辛东. 新生儿急救学.北京:人民卫生出版社,2000,614.]
4 Wang WH, Wang XL.Clinical significance of neonatal asphyxia blood glucose monitoring. Xinjiang Med J, 2007,37:87-88.[王文辉,王雪莉.新生儿窒息血糖监测的临床意义. 新疆医学,2007,37:87-88.]
5 Liang JM, Liu YB, Huo SF. A clinical study on internal milieu disorder in children with critical viral encephalitis. Chin J Pract Pediatr, 2004,19: 477-479.[梁建民,刘延波,霍淑芳.重症病毒性脑炎患儿内环境紊乱的临床研究. 中国实用儿科杂志,2004, 19: 477-479.]
6 Lv XH, Yang XZ.Clinical significance of neonatal asphyxia blood glucose monitoring. J Appl Clin Pediatr, 2003, 18:457-458.[吕修华,杨秀珍.新生儿窒息血糖监测的临床意义. 实用临床儿科杂志,2003, 18: 457-458.]
7 Luo XP,Li YX.Neonatal hypoglycemia and hyperglycemia the diagnosis and treatment. Chin J Obstet Pract Women Children, 2003, 19: 338-340.[罗小平,李玉祥.新生儿低血糖症与高血糖症的诊治.中国实用妇幼与产科杂志,2003, 19: 338-340.]
8 Ma YH, Xu M, Jia TJ. Neonatal asphyxia influence on the blood electrolytes and liver and kidney function.J China Microcirculation Dec, 2006,10: 444-445.[马玉华,徐明,贾同军. 新生儿窒息对血电解质及肝肾功能的影响.中国微循善环,2006, 10: 444-445.]
9 Wei L.The clinical significance of the changes of blood sugar and seruin electrolytes in asphyxia of newborn. Modern Hospital, 2008, 8: 42-43.[魏莉.新生窒息后血糖及电解质改变的临床意义. 现代医院,2008, 8: 42-43.]
10 Wang YT, Liu SX, Wei LY, et al. Newborn asphyxia serum electrolyte the clinical significance of changes. Clin Pract, 2005, 23:97.[王永太,刘素霞,韦兰英等.窒息新生儿血清电解质变化的临床意义.临床实践,2005,23:97.]
11 Wu YB. Neonatal asphyxia, changes in liver and kidney function and electrolyte analysis. Chin Med J Communicat, 2005, 19: 697. [吴义平.新生儿窒息时肝肾功能及电解质变化分析.中国交通医学杂志,2005, 19: 679.]
12 Zhao ZY, Yan BL, Hao LH, et al. Pathophysiology and treatment of hyponatremia.Med Recapitul, 2008,14: 249-250.[赵战云,颜炳丽,郝立海等. 低钠血症的病理生理及治疗. 医学综述,2008, 14: 249-250.]
13 Wang Y. Clinical significance of serum calcium and magnesium in neonatal asphyxia. J Med Theory Pract, 2006, 19: 327-328.[王颖.新生儿窒息血清钙镁测定的临床意义. 医学理论与实践,2006, 19: 327-328.]
14 Fu ZQ, Xu H, Chen X. Implications from the treatment of serum decrease in neonatal asphyxia. J Clin Res, 2006, 23: 1834-1835.[付中秋,徐宏,陈霞. 新生儿窒息后血钙降低的临床分析及治疗体会.医学临床研究,2006,23:1834-1835.]
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